ClinicalTrials.gg
RecruitingNCT07254234Updated Sep 24, 2026

A Study of Retinal Imaging to Detect Abnormal Protein Deposits Associated With Alzheimer's Disease

An observational study in Cognitive Dysfunction and Memory Disorders, sponsored by Eli Lilly and Company. Recruiting at 3 sites in United Arab Emirates. Open to participants aged 55 Years and older. Per ClinicalTrials.gov, last updated 2026-09-24.

Sponsored by Eli Lilly and Company · Observational

From the registry’s dates

  • Started Sep 2026; still recruiting 1 month later.
Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
200
Ages
55 Years and older
Sex
All
01

Study summary

The purpose of this study is to test the use of a screening tool to detect changes in the eye that are associated with Alzheimer's disease in adult participants with memory issues. For each participant, the study will last up to one month and requires one visit to the research site.

02

Conditions studied

  • Cognitive Dysfunction
  • Memory Disorders
03

In context

Cognitive Dysfunction

3,872 studies on the registry are indexed under Cognitive Dysfunction; 1,119 are open to participants now.

This study's planned enrollment of 200 is above the median of 150 across 997 observational studies indexed under Cognitive Dysfunction.

Browse Cognitive Dysfunction studies →

Lead sponsor

Eli Lilly and Company is the lead sponsor of 2,106 studies on the registry; 152 are open to participants now.

Of its 536 completed or terminated interventional studies of FDA-regulated products, 357 (67%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
55 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Emiratis age 55 or older with mild memory complaints or MCI who are otherwise healthy.

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Participants who are overtly healthy as determined by medical evaluation, including medical history and physical examination.
  • Have mild memory complaints or a diagnosis of mild cognitive impairment.
  • Have undergone genotyping for apolipoprotein E (APOE) and are willing to make results available to the investigator.
  • (MoCA) score of greater than or equal to 22 and less than or equal to 28.

Exclusion criteria

Exclusion Criteria:

  • Have any medical condition that, in the opinion of the investigator, would be a to participation in the study.
  • Have an existing diagnosis of AD or other dementia.
  • Have contradictions to or an allergy to the ophthalmic dilating agents.
  • Have known diagnosis of severe glaucoma or severe cataracts; have a significant refractive error (more than 12 diopters [D] of spherical equivalent refraction); or have any ocular media opacity that prevents imaging of the retina (that is, severe cataract). Note: mild to moderate cataracts or vision correction with glasses or contact lenses are not exclusion criteria.
  • Current or previous treatment with anti-amyloid medications.
  • Are currently enrolled in any other clinical study involving an product or any other type of medical research judged not to be scientifically or medically compatible with this study.
Terms in these criteria, in plain language(3)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

MMSE and MoCA

Short tests of memory and thinking, each scored out of 30. Lower scores suggest more difficulty; criteria give a range, either to include people with memory problems or to leave them out.

Contraindication

A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.

Investigational drug or device

A drug or device being studied in a clinical trial.

It may be new, or already approved and being studied for another use, dose or form. Criteria often leave out people who took part in another study of one within a recent period, commonly 30 days or five half-lives.

05

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
200 participants (estimated)
Patient registry
No

Groups and cohorts

  • Participants with Memory Complaints or Mild Cognitive Impairment (MCI)

    Retinal scan and blood biomarker testing

    Other: Retinal scan · Other: Blood test

Interventions

  • OtherRetinal scan

    Detailed image of the retina.

  • OtherBlood test

    Sample will be used to test for a specific form of a protein in the blood to learn more about early detection of Alzheimer's disease.

06

What researchers measure

Primary outcomes

  1. Percentage of Participants with the Same Results on the Blood Test and Retinal Scan

    Time frame: Day 1

Secondary outcomes

  1. Percentage of Participants who Report High or Moderate Satisfaction with Retinal Scan

    Measured by 5-item retinal scan feedback survey. Participants rate their experience with the retinal scan on a 5-item Likert scale that ranges from "Strongly Disagree" to "Strongly Agree." Higher scores are better.

    Time frame: Day 1

07

Study locations

2 of 3 sites recruiting
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Sep 24, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT07254234
Responsible party
Sponsor
First posted
Nov 28, 2025
Start date
Sep 23, 2026
Primary completion
Sep 2027 (estimated)
Completion
Sep 2027 (estimated)
Last update
Sep 24, 2026

Study contacts

Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or
Contact
LillyTrials@Lilly.com
1-317-615-4559
Physicians interested in becoming principal investigators please contact
Contact
clinical_inquiry_hub@lilly.com
Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 8 AM - 8 PM Eastern time (UTC/GMT - 5 hours, EST)
study director · Eli Lilly and Company

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Interested in this study?

Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.

Contact study team

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Start the discussion