Nellcor™ Investigational Device Sitting-Walking Study

• Male or female participants ≥18 years of age, and \<75 years of age.
• Participant is able to participate for the duration of the study
• Participant is willing to sign an informed consent form (ICF)
• Participant weighs > 40kg
• Participants must be a non-smoker or not have smoked within 36 hours prior to the study

Exclusion Criteria:

• Participant self-reported prior injury or trauma to fingers or hands, which in the opinion of the investigator, may change blood flow or vascular supply and affect the ability to test sensors
• Physiologic abnormalities that prevent proper application of pulse oximetry sensor
• Severe contact allergies that cause a reaction to standard adhesive materials such as those found in medical sensors and electrodes
• Individuals of childbearing potential who are self-reported as pregnant, or who are self-reported as trying to get pregnant
• Morbid obesity (defined as BMI > 39.5)
• Weight > 136 kg
• Participants who self-report problems of unsteadiness or imbalance issues and/or who are unable to walk on a treadmill without holding onto the handrails
• Participant self-reported known heart or cardiovascular conditions such as:
• Uncontrolled hypertension (Systolic pressure ≥ 140mmHg or Diastolic pressure > 90mmHg on 3 consecutive readings day of screening)
• Heart arrhythmias other than sinus arrhythmia (Self-reported and/or as identified on ECG day of screening).
• History of heart attack, blocked artery, history of myocardial ischemia, angina, myocardial infarction, congestive heart failure, cardiomyopathy, stroke, transient ischemic attack, or carotid artery disease
• Participants with self-reported clotting disorders, such as:
• History of bleeding disorders or personal history of prolonged bleeding from injury
• History of blood clots
• Hemophilia
• Current use of prescription blood thinner
• Participants with other self-reported, known health conditions, such as:
• Diabetes
• Thyroid disease
• Kidney disease / chronic renal impairment
• History of seizures (except childhood febrile seizures), epilepsy, or unexplained syncope
• Recent history of frequent migraine headaches, as determined medically relevant by the PI
• History of head injury, as determined medically relevant by the PI
• Cancer / chemotherapy
• Sickle cell disease
• History of hospital admission or a surgical procedure in the 60 days prior to study enrollment (self-reported)
• Participants with any contraindications to protocol specific repositioning techniques
• Unwillingness or inability to remove colored nail polish from test digit(s)
• Participants who have self-reported health conditions beyond what is captured in the prior exclusion criteria, which in the opinion of the Investigator and/or Clinical Staff would classify the participant as medically unsuitable