An interventional study of Resistance exercise with low AOP and Resistance exercise with moderate BFR in Rotator Cuff Related Shoulder Pain, sponsored by University of Valencia. Recruiting at 1 site in Spain. Open to participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2026-05-04.
Sponsored by University of Valencia · Not applicable, Interventional, and Treatment
This study aims to compare the effects of blood flow restricted (BFR) exercise and to examine the differences between various BFR protocols on acute pain reduction in individuals with rotator cuff-related shoulder pain, as well as the exercise tolerance at each intensity and occlusion setting. There are four exercise modalities corresponding to different combinations of intensity (%RM) and percentage of occlusion (%AOP): 1) 30% RM and 30% AOP; 2) 30% RM and 50% AOP; 3) 30% RM and 70% AOP; 4) 30% RM and BFR placebo (cuff without pressure).
All participants will complete one session of each of the four exercise modalities, analyzing the variables studied in each for subsequent analysis and comparison.
2,426 studies on the registry are indexed under Motor Activity; 1,161 are open to participants now.
This study's planned enrollment of 30 is below the median of 60 across 2,118 interventional studies indexed under Motor Activity.
Browse Motor Activity studies →University of Valencia is the lead sponsor of 349 studies on the registry; 73 are open to participants now.
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Exclusion Criteria:
A single session of exercise, 30% repetition maximum, and 30% blood occlusion
Device: Resistance exercise with low AOP
A single session of exercise, 30% repetition maximum, and 50% blood occlusion
Device: Resistance exercise with moderate BFR
A single session of exercise, 30% repetition maximum, and 70% blood occlusion
Device: Resistance exercise with high BFR
A single session of exercise, 30% repetition maximum, and without blood restriction (cuff applied without pressure)
Device: Resistance exercise with sham BFR
Three exercises: external rotation at 0°, internal rotation at 0° and elevation in the scapular plane. 4 sets (30, 15, 15, reps to fatigue) with a intensity of 30% RM and a 30% of arterial occlusion pressure. 30" rest between sets, 2' rest between exercises.
Three exercises: external rotation at 0°, internal rotation at 0° and elevation in the scapular plane. 4 sets (30, 15, 15, reps to fatigue) with a intensity of 30% RM and a 50% of arterial occlusion pressure. 30" rest between sets, 2' rest between exercises.
Three exercises: external rotation at 0°, internal rotation at 0° and elevation in the scapular plane. 4 sets (30, 15, 15, reps to fatigue) with a intensity of 30% RM and a 70% of arterial occlusion pressure. 30" rest between sets, 2' rest between exercises.
Three exercises: external rotation at 0°, internal rotation at 0° and elevation in the scapular plane. 4 sets (30, 15, 15, reps to fatigue) with a intensity of 30% RM and a sham blood flow restriction application (cuff applied without pressure). 30" rest between sets, 2' rest between exercises.
Pain intensity at rest (Visual Analogue Scale, 0-10)
Pain intensity perceived on a Visual Analogue Scale, at rest, being 0 no pain and 10 the worst pain imaginable.
Time frame: Periprocedural
Pain intensity during movement (Visual Analogue Scale, 0-10)
Pain intensity perceived on a Visual Analogue Scale during movement (flexion and abduction movement without load), being 0 no pain and 10 the worst pain imaginable
Time frame: Periprocedural
Pressure pain threshold
Pressure pain threshold measured in the middle deltoid (peripheral sensitivity) and tibialis anterior (central sensitivity), using an algometer
Time frame: Periprocedural
Exercise tolerance with each setting
Exercise tolerance with each setting according to the following 5-point scale: well tolerated, tolerated, neutral, poorly tolerated, not tolerated.
Time frame: Periprocedural
Occurrence of adverse effects
Occurrence of adverse effects (e.g., pain, delayed onset muscle soreness, sudden weakness of the trained limb, redness or swelling of the trained limb, etc.) by self-report.
Time frame: Immediately after the intervention, 1 hour, 6 hours, 24 hours
Surface electromyography
Surface electromyography for the study of muscle recruitment (middle deltoid, infraspinatus, teres minor and trapezius muscles)
Time frame: Periprocedural
Plan to share: Undecided — The data that support the findings of this study will be available from the corresponding author upon reasonable request.
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University of Valencia