An observational study in General Population (no Specific Condition or Disease), sponsored by Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement. Recruiting at 1 site in France. Open to participants aged 18 Years to 60 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-01-13.
Sponsored by Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement · Observational
The gut microbiota plays a crucial role in health through its involvement in pathogen defense, immune regulation, and nutrient digestion. Microbiota diversity is essential to maintain these functions, and disturbances caused by antibiotic intake or extreme diets can lead to an imbalance (dysbiosis), which is often described as being implicated in numerous diseases as well as in the proliferation of antibiotic-resistant pathogens.
The microbiota is defined as the community of microorganisms inhabiting the intestine, including bacteria, viruses, and bacteriophages (phages). These phages, through their ability to destroy the bacteria they infect, play an important role in regulating bacterial populations and could therefore be essential for restoring balance and diversity in the gut.
Probiotics, foods that support the microbiota such as dairy products, are of particular interest because the specific interactions between phages and bacteria within these food microbiomes could stimulate microbiota restoration.
This study aims to evaluate the effectiveness of phage-based functional foods in restoring intestinal homeostasis and, by extension, improving human health. It will serve as a model to examine how phages present in foods, particularly dairy products, influence gut microbial diversity and to determine whether these phages promote recovery after antibiotic-induced disturbances.
1,327 studies on the registry are indexed under Disease; 596 are open to participants now.
This study's planned enrollment of 4 is below the median of 215 across 573 observational studies indexed under Disease.
Browse Disease studies →Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement is the lead sponsor of 47 studies on the registry; 14 are open to participants now.
Counted across the registry records on this site, refreshed daily.
General population residing in Paris Region (Ile-de-France)
Exclusion Criteria:
Primary Outcome
To assess the ability of dairy phages to modulate the intestinal microbiota in vitro using a fermenter system, in the presence and absence of antibiotics.
Time frame: Up to 3 years
Secondary Outcome
To monitor the temporal dynamics of the intestinal microbiota following the addition of dairy phages and antibiotics.
Time frame: Up to 3 years
Plan to share: No
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Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement