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CompletedNCT07206680Updated Mar 9, 2026

Effect of Extracorporeal Shockwave Therapy on Pruritus in Neurodermatitis Patients

An interventional study of Shockwave therapy and Emollients & corticosteroids in Neurodermatitis, sponsored by Cairo University. Completed at 1 site in Egypt. Open to participants aged 55 Years to 75 Years. Per ClinicalTrials.gov, last updated 2026-03-09.

Sponsored by Cairo University · Not applicable, Interventional, and Treatment

From the registry’s dates

  • Registered 9 months after the study started (first participant enrolled Dec 2024, registered Sep 2025).
Phase
Not applicable
Study type
Interventional
Enrollment
34
Allocation
Randomized
Ages
55 Years to 75 Years
Sex
All
01

Study summary

The purpose of this study is to evaluate the therapeutic effect of shockwave therapy on reducing pruritus in neurodermatitis patients.

Read the detailed description

Based on the occurrence of side effects caused by conventional medication for prolonged employment, dermatologists and patients show solicitude for multifaceted effective methods to control the chronic and relapsing nature of neurodermatitis.

Although new modalities are continuously coming up for pruritus, there remains a great gap for providing symptom relief.

Furthermore, there is a lack in the quantitative knowledge and information in the published studies about benefits of shockwave therapy on the treatment of pruritus in neurodermatitis patients. So, this study is designed to outline the therapeutic efficacy of shockwave therapy on the treatment of pruritus in neurodermatitis patients.

02

Conditions studied

  • Neurodermatitis

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03

In context

Neurodermatitis

22 studies on the registry are indexed under Neurodermatitis; 3 are open to participants now.

This study's enrollment of 34 is below the median of 44 across 22 interventional studies indexed under Neurodermatitis.

Browse Neurodermatitis studies →

Lead sponsor

Cairo University is the lead sponsor of 4,941 studies on the registry; 1,458 are open to participants now.

Of its 37 completed or terminated interventional studies of FDA-regulated products, 5 (14%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
55 Years to 75 Years
Sexes eligible
All
Accepts healthy volunteers
No

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Age range between 55:75 years.
  • Male and female patients will participate in the study.
  • All patients have neurodermatitis.
  • All patients will be received the same approach of medication and nursing care.
  • All patients enrolled in the study will have their .

Exclusion criteria

Exclusion Criteria:

  • Patients diagnosed with cancer.
  • Pregnant woman.
  • active infection.
  • Patients with any systemic diseases that may interfere with the objectives of the study.
  • Cardiac pacemakers or other implantable devices.
  • Current anticoagulation use.
  • Any other cause of itching
Terms in these criteria, in plain language(1)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

Informed consent

Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.

You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.

05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
34 participants (actual)

Study arms

  • Experimental
    Shockwave therapy + corticosteroids + emollients

    It will include 17 patients suffering from neurodermatitis who will receive shockwave therapy for 10min, 4 sessions, once per week and emollients \& corticosteroids for a month.

    Device: Shockwave therapy · Drug: Emollients & corticosteroids

  • Active comparator
    Corticosteroids & Emollients

    It will include 17 patients suffering from neurodermatitis who will receive their emollients \& corticosteroids only for a month.

    Drug: Emollients & corticosteroids

Interventions

  • DeviceShockwave therapy

    The procedures for Extracorporeal Shockwave Therapy (ESWT) involve several steps. First, the patient is positioned comfortably, and the physiotherapist explains the treatment procedure. Before the session begins, the device cables are checked for proper functioning. The shockwave type used is Non-Focused/Radial, with a treatment duration not exceeding 10 minutes. The frequency is set at 4 Hz, and the intensity ranges from 0.05 to 0.20 mJ/mm². Each session involves a total of 1000 to 2000 shocks. The treatment consists of four sessions, each held once a week.

  • DrugEmollients & corticosteroids

    Patients in both groups will receive emollients \& corticosteroids for one month.

06

What researchers measure

Primary outcomes

  1. 5-D Itching Scale

    The 5-D Itching Scale will be used to assess the improvement of cases by evaluating pruritus severity. Patients will complete the scale both before starting the treatment and at four sessions following the treatment. The following steps will be followed during the assessment: the patient will be positioned comfortably (sitting position), the physiotherapist will explain the pruritus symptoms score to the patient, and the patient will determine their points on the 5-D itch scale.

    Time frame: one month

07

Study locations

1 site
  • Suez Canal University Hospital
    Ismailia, Egypt
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Mar 9, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT07206680
Lead sponsor
Cairo University
Responsible party
Abd Al Rahman Khaled Muhammed Muhammed (Principal Investigator, Cairo University) — Principal investigator
First posted
Oct 3, 2025
Start date
Dec 15, 2024
Primary completion
Sep 15, 2025
Completion
Oct 25, 2025
Last update
Mar 9, 2026

Study contacts

Nessrien Afify Abd El Rashid, PhD
study chair · Assistant Professor, Cairo University
Noha Zakaria Tawfik, PhD
study director · Assistant Professor, Suez Canal University
Doaa Atef Aly, PhD
study director · Lecturer, Cairo university

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Sep 2025. You cannot join it, but the record below documents what was studied.

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