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TerminatedNCT07202702Updated Jun 1, 2026

Modulation of Motor Learning Via tDCS in a Dexterous Video Game Task

An interventional study of tDCS in Motor Activity, sponsored by Indiana University. Terminated at 1 site in United States. Open to participants aged 18 Years to 45 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-06-01.

Sponsored by Indiana University · Not applicable, Interventional, and Treatment

Why this study was terminated
An equivalence analysis demonstrated no statistical difference, and bayesian inference testing showed the potential for only a negligible effect.

From the registry’s dates

  • Registered 4 months after the study started (first participant enrolled Apr 2025, registered Aug 2025).
Phase
Not applicable
Study type
Interventional
Enrollment
40
Allocation
Randomized
Ages
18 Years to 45 Years
Sex
All
01

Study summary

The purpose of this study is to determine whether "transcranial direct current stimulation" (tDCS) is effective in enhancing learning of complex motor tasks of precision and accuracy that require the simultaneous coordination of both hands. The study will utilize a between-subjects, SHAM controlled design. Subjects will be randomly selected to receive either SHAM (n=26) or a-tDCS (n=26) stimulation and will be blinded to their condition throughout testing. Subjects will complete a total of two testing sessions, separated by \~24 hours. Both sessions will have the subject play the videogame "Guitar Hero", with a single song done for several trials as pre- and post-assessments. The first session will contain a 20-minute practice/stimulation block where subjects practice the guitar task while receiving either "active" or "inactive" stimulation of the motor cortex. The first session will last approximately 75 to 90 minutes whereas the second session will last approximately 15 to 20 minutes.

02

Conditions studied

  • Motor Activity

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03

In context

Motor Activity

2,426 studies on the registry are indexed under Motor Activity; 1,161 are open to participants now.

This study's enrollment of 40 is below the median of 60 across 2,118 interventional studies indexed under Motor Activity.

Browse Motor Activity studies →

Lead sponsor

Indiana University is the lead sponsor of 958 studies on the registry; 200 are open to participants now.

Of its 142 completed or terminated interventional studies of FDA-regulated products, 112 (79%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 45 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Inclusion criteria

  • Between ages 18 and 45 years old (to avoid any changes in the developing brain, or with aging).
  • Answer 'no' to questions 2 through 16 on the tDCS checklist as these factors can increase likelihood of adverse events with tDCS
  • No neurological damage, disease, or dysfunction (nerve damage, chronic pain disorders, diabetic neuropathy) that affect the upper limbs.
  • No significant acute or chronic medical, neurologic, or illness in the patient that, in the judgment of the Principal Investigator, could compromise subject safety, limit the ability to complete the study, and/or compromise the objectives of the study

Exclusion criteria

Exclusion Criteria:

    • Currently prescribed and taking stimulant medication (Adderall, Ritalin, Vyvanse, etc.)

      • Consumption of over-the-counter stimulants such as caffeine or nicotine (coffee, soda, supplements, energy drinks, tobacco products, or other nicotine containing products such as gum, vape pens, etc...) 12 hours prior to entering the lab on the day of testing as this can directly affect cortical excitability. If a subject takes any of these substances 12 hours prior to session 1 they will be asked to reschedule for a later date.
      • Have played a real stringed instrument in the last 12 months (e.g. guitar, bass, violin)
      • Have played the videogame "Guitar Hero" on a traditional guitar controller in the last 12 months.
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Single (Participant)
Enrollment
40 participants (actual)

Study arms

  • Experimental
    tDCS

    This group will receive 20 minutes of 1 mA tDCS stimulation to the motor cortex while playing the videogame.

    Device: tDCS

  • Placebo comparator
    SHAM

    This group will receive 30 seconds of 1 mA tDCS stimulation to the motor cortex and then it will shut off, effectively serving as a control, while subjects play the videogame for 20 minutes

    Device: tDCS

Interventions

  • DevicetDCS

    Applying tDCS to determine if it facilitates learning of a video game task

06

What researchers measure

Primary outcomes

  1. Improvement in a video game

    To determine whether a-tDCS influences motor skill acquisition of a dexterous video game task by measuring the outcome of videogame performance (number of notes played) with and without a-tDCS

    Time frame: 1 year

Secondary outcomes

  1. Retention and Learning

    Learning will be measured within-groups by examining retention, or the outcome of video game performance (number of notes played) between the first and second sessions

    Time frame: 1 Year

07

Study locations

1 site
  • National Institute for Fitness and Sport
    Indianapolis, Indiana 46202, United States
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References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jun 1, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT07202702
Lead sponsor
Indiana University
Responsible party
Zachary Riley (Associate Professor, Indiana University) — Principal investigator
First posted
Oct 2, 2025
Start date
Apr 4, 2025
Primary completion
Dec 3, 2025
Completion
Dec 3, 2025
Last update
Jun 1, 2026

Study contacts

Zachary Riley
principal investigator · Indiana University

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
Yes
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is terminated, as verified in May 2026. You cannot join it, but the record below documents what was studied.

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