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Active, not recruitingNCT07202260PRACTICALUpdated Oct 1, 2025

Pragmatic Analysis of Complex Radiotherapy Cases In Cancer of the Lung

An observational study in Lung Cancer (NSCLC) and Lung Cancer (SCLC), sponsored by The Christie NHS Foundation Trust. Active, not recruiting at 1 site in United Kingdom. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-10-01.

Sponsored by The Christie NHS Foundation Trust · Observational

Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
80
Ages
18 Years and older
Sex
All
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Study summary

This study focuses on improving care for people with lung cancer who face unusual or complex treatment situations.

Read the detailed description

By studying detailed patient data, researchers aim to find the best ways to treat these patients while reducing short- and long-term side effects. The findings will help refine radiotherapy treatments, ensuring they are as safe and effective as possible. Additionally, the results will provide doctors with better information to help patients understand the potential risks and benefits of their treatment options.

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Conditions studied

  • Lung Cancer (NSCLC)
  • Lung Cancer (SCLC)

Keywords

  • radiotherapy
  • interstitial lung disease
  • vascular invasion
  • re-irradiation
  • rare histology
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In context

Lung Neoplasms

7,243 studies on the registry are indexed under Lung Neoplasms; 1,557 are open to participants now.

This study's planned enrollment of 80 is below the median of 189 across 1,514 observational studies indexed under Lung Neoplasms.

Browse Lung Neoplasms studies →

Lead sponsor

The Christie NHS Foundation Trust is the lead sponsor of 99 studies on the registry; 25 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Patients over 18 years of age, with stage I, II or III lung cancer undergoing curative-intent radiotherapy at the Christie Hospital.

Eligibility criteria

Inclusion Criteria: Complex patients with lung cancer undergoing radiotherapy in one of the following groups;

  • Rare histology
  • Disease invading vascular structures
  • Co-existing interstitial lung disease (ILD)
  • Radical re-irradiation
  • Oligopersistent/oligoprogressive disease on immunotherapy or targeted therapies.

Exclusion Criteria:

  • Include patients with stage IV disease who are receiving non-curative intent radiotherapy
  • There are no exclusion criteria relating to upper age limit or comorbidities.
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Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
80 participants (estimated)
Target follow-up
2 Years
Patient registry
Yes

Groups and cohorts

  • Patients with co-existing interstitial lung disease
  • Patients who undergo radiotherapy twice to the same area (reirradiation).
  • Patients with the less common or rare types of lung cancer
  • Patients with cancer invading large blood vessels.
  • Patients with oligopersistent/oligoprogressive disease on immunotherapy or targeted therapies.
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What researchers measure

Primary outcomes

  1. Acute and late toxicity

    \- Acute (\<90 days post radiotherapy) and late (\> 90 days post radiotherapy) toxicity according to common terminology criteria for adverse events (CTCAE) V5.

    Time frame: 2 years

Other outcomes

  1. Patient reported quality of life

    \- Patient reported quality of life (QOL) information from electronic patient reported outcome measure (ePROM) questionnaires.

    Time frame: 2 years

  2. Survival

    \- Progression-free survival and overall survival.

    Time frame: 2 years

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Study locations

1 site
  • The Christie NHS Foundation Trust
    Withington, Greater Manchester M20 1BX, United Kingdom
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References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Oct 1, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT07202260
Lead sponsor
The Christie NHS Foundation Trust
Responsible party
Sponsor
First posted
Oct 1, 2025
Start date
Jul 3, 2025
Primary completion
Jul 15, 2028 (estimated)
Completion
Dec 1, 2028 (estimated)
Last update
Oct 1, 2025

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is active, not recruiting, as verified in Sep 2025. You cannot join it, but the record below documents what was studied.

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