An observational study in Diffuse Large B-Cell Lymphoma, sponsored by Hoffmann-La Roche. Recruiting at 22 sites in 2 countries. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-09-08.
Sponsored by Hoffmann-La Roche · Observational
This study will investigate how well glofitamab-based therapy works and how safe it is in Chinese adult participants with relapsed or refractory diffuse large B-cell lymphoma (R/R DLBCL).
Adult Chinese participants with R/R DLBCL who will be treated with a glofitamab-based regimen either after enrollment into the study or within 90 days prior to enrollment.
Exclusion Criteria:
Participants will be enrolled into the study either prior to initiation of glofitamab therapy or within 90 days of starting glofitamab therapy.
Drug: Glofitamab
Participants will receive glofitamab as part of a cancer-treatment regimen in a real-world setting. No intervention will be administered by study investigators.
real-world Progression-Free Survival (rwPFS)
Time frame: Up to approximately 4 years
Complete Response Rate (CRR)
CRR is defined as the proportion of participants whose best overall response (BOR) is a complete response (CR) on positron emission tomography/computed tomography (PET/CT) or CT during the study assessed by the investigator according to 2014 Lugano Response Criteria for Malignant Lymphoma
Time frame: Up to approximately 4 years
Overall Response Rate (ORR)
ORR is defined as the proportion of patients whose BOR is a CR or a partial response (PR) during the study assessed by the investigator according to 2014 Lugano Response Criteria for Malignant Lymphoma
Time frame: Up to approximately 4 years
Disease Control Rate (DCR)
DCR is defined as the proportion of patients achieving CR, PR or stable disease (SD) during the study assessed by the investigator according to 2014 Lugano Response Criteria for Malignant Lymphoma
Time frame: Up to approximately 4 years
Duration of Response (DoR)
DoR is defined as the time interval from the first occurrence of a documented objective response (CR or PR) to disease progression or death from any cause, whichever occurs first assessed by the investigator according to 2014 Lugano Response Criteria for Malignant Lymphoma
Time frame: Up to approximately 4 years
Duration of Complete Response (DoCR)
DoCR is defined as the time interval from the first occurrence of a documented CR to disease progression or death from any cause, whichever occurs first
Time frame: Up to approximately 4 years
Overall Survival (OS)
OS is defined as the time from treatment start of the Glofit-based regimen until the date of death from any cause
Time frame: Up to approximately 4 years
Event-Free Survival (EFS)
EFS is defined as the time from treatment start of the Glofit-based regimen to any treatment failure including disease progression, relapse, initiation of new antilymphoma therapy (NALT), or death from any cause, which occurs first, as determined by the investigator assessment according to 2014 Lugano Response Criteria for Malignant Lymphoma
Time frame: Up to approximately 4 years
Time to Next Treatment (TTNT)
TTNT is defined as the time from treatment start of the Glofit-based regimen to the initiation of next-line treatment
Time frame: Up to approximately 4 years
Plan to share: No
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Lymphoma, Large B-Cell, Diffuse→
Hoffmann-La Roche