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Not yet recruitingNCT07198802Updated Sep 30, 2025

Molecular Research on Predictive Efficacy and New Therapeutic Targets for Nasopharyngeal Carcinoma

An observational study in Nasopharyngeal Carcinoma (NPC), sponsored by Union Hospital, Tongji Medical College, Huazhong University of Science and Technology. Not yet recruiting. Open to participants aged 15 Years to 75 Years. Per ClinicalTrials.gov, last updated 2025-09-30.

Sponsored by Union Hospital, Tongji Medical College, Huazhong University of Science and Technology · Observational

Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
600
Ages
15 Years to 75 Years
Sex
All
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Study summary

To analyze the spatiotemporal dynamic evolution of nasopharyngeal carcinoma before and after immunotherapy and during tumor progression, 2\~3 key cell subsets or node molecules were screened to predict the curative effect. Spatial metabolome and organoids were used to elucidate the mechanism of key factors leading to immunotherapy tolerance in NPC and identify new targets for intervention.

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Conditions studied

  • Nasopharyngeal Carcinoma (NPC)
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In context

Nasopharyngeal Carcinoma

816 studies on the registry are indexed under Nasopharyngeal Carcinoma; 282 are open to participants now.

This study's planned enrollment of 600 is above the median of 300 across 135 observational studies indexed under Nasopharyngeal Carcinoma.

Browse Nasopharyngeal Carcinoma studies →

Lead sponsor

Union Hospital, Tongji Medical College, Huazhong University of Science and Technology is the lead sponsor of 160 studies on the registry; 129 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
15 Years to 75 Years
Sexes eligible
All
Sampling method
Probability sample

Study population

Patients with nasopharyngeal carcinoma who were admitted to our hospital

Eligibility criteria

Inclusion Criteria Before the trial, the participants must meet all of the following requirements to be eligible for inclusion.

  1. Clearly diagnosed with nasopharyngeal carcinoma by pathology;
  2. Patients who have received combined radiotherapy, chemotherapy and immunotherapy in our hospital;
  3. Patients diagnosed in our hospital from January 2025 to December 2028;
  4. Have relatively complete clinical data;
  5. Age between 15 and 75 years old;

Exclusion Criteria Before the trial, the participants who meet any of the following requirements cannot be included.

  1. The final diagnosis of the participants is other diseases, including lymphoma, or oropharyngeal cancer, etc.;
  2. The participants failed to obtain pathological and imaging data for various reasons;
  3. Due to physical conditions, they did not undergo relevant examinations, refused to accept examinations, or interrupted treatment for other reasons, and were unable to complete clinical assessment.
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Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
600 participants (estimated)
Patient registry
No

Groups and cohorts

  • Study Groups

    Other: No Intervention

Interventions

  • OtherNo Intervention

    This project involves no therapeutic intervention for the subjects.

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What researchers measure

Primary outcomes

  1. Failure-free survival (FFS)

    Failure-free survival is measured from day of diagnosis until treatment failure, death from any cause, or last follow-up visit, whichever occurred first

    Time frame: 3-year

Secondary outcomes

  1. Overall survival (OS)

    Overall survival is measured from day of diagnosis until death due to any cause or the latest known date alive

    Time frame: 5-year

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Study locations

No study locations are listed for this record.

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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Sep 30, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT07198802
Lead sponsor
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Responsible party
Sponsor
First posted
Sep 30, 2025
Start date
Oct 2025 (estimated)
Primary completion
Dec 2028 (estimated)
Completion
Dec 2028 (estimated)
Last update
Sep 30, 2025
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is not yet recruiting, as verified in Sep 2025. You cannot join it, but the record below documents what was studied.

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Discussion

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