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CompletedNCT07194031Updated Sep 26, 2025

The Acute Effects of Ankle Exercises on Knee Proprioception

An interventional study of Ankle Exercise and Knee Exercise in Knee Pain Chronic, sponsored by Gaziantep Islam Science and Technology University. Completed at 1 site in Turkey (Türkiye). Open to participants aged 18 Years to 70 Years. Per ClinicalTrials.gov, last updated 2025-09-26.

Sponsored by Gaziantep Islam Science and Technology University · Not applicable, Interventional, and Treatment

From the registry’s dates

  • Registered 8 months after the study started (first participant enrolled Jan 2025, registered Sep 2025).
Phase
Not applicable
Study type
Interventional
Enrollment
114
Allocation
Randomized
Ages
18 Years to 70 Years
Sex
All
01

Study summary

The goal of this randomized research study is to investigate the acute effects of ankle exercises on improving knee proprioception and pain in individuals with knee pain, aged 18-70, who receive intervention-based ankle and knee exercises to treat their knee pain. The main question it aims to answer is:

  • Does ankle exercise affect knee joint proprioception and pain in individuals with knee pain? Researchers will compare ankle exercise (the intervention) with knee exercise (as part of their regular medical care for knee pain) to determine if ankle exercise is effective in improving knee joint proprioception and reducing pain.

Participants will be asked to do exercises and to let the researchers take their measurements.

02

Conditions studied

  • Knee Pain Chronic

Keywords

  • Ankle
  • Exercise
  • Knee
  • Pain
  • Proprioception
03

In context

Motor Activity

2,426 studies on the registry are indexed under Motor Activity; 1,161 are open to participants now.

This study's enrollment of 114 is above the median of 60 across 2,118 interventional studies indexed under Motor Activity.

Browse Motor Activity studies →

Lead sponsor

Gaziantep Islam Science and Technology University is the lead sponsor of 39 studies on the registry; 10 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 70 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • The participants who have a VAS pain score >5,
  • The participants who have experienced knee pain for the last six months or longer,
  • The participants who volunteered to participate in the study

Exclusion criteria

Exclusion Criteria:

  • Individuals who had undergone knee and ankle surgery within the last year
  • Individuals who have a VAS pain score below 5
  • Individuals who are experiencing ROM limitations in the knee or ankle
  • Individuals who have a neurological pathology in the lower extremity
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Single (Participant)
Enrollment
114 participants (actual)

Study arms

  • Active comparator
    Knee exercise

    Knee flexion-extension

    Other: Knee Exercise

  • Experimental
    Ankle exercise

    Ankle plantar flexion with body weight

    Other: Ankle Exercise

Interventions

  • OtherAnkle Exercise

    In the literature, studies have evaluated ankle proprioception following interventions applied to the knee. However, no studies report the effects of ankle exercises on knee proprioception

    Also known as: Plantar flexion

  • OtherKnee Exercise

    The literature emphasizes that long-term and multidirectional exercise programs provide proprioceptive improvements

    Also known as: Knee flexion-extension

06

What researchers measure

Primary outcomes

  1. Knee proprioception

    Knee flexion- extension position

    Time frame: 4 weeks

Secondary outcomes

  1. Knee pain

    Visual Analogue Scale (VAS); Zero, no pain; 10 worst pain

    Time frame: 4 weeks

07

Study locations

1 site
  • Gaziantep Islam Science and Technology University
    Gaziantep, Turkey (Türkiye)
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Sep 26, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT07194031
Lead sponsor
Gaziantep Islam Science and Technology University
Responsible party
Gönül Elpeze (Associated Proffessor, Gaziantep Islam Science and Technology University) — Principal investigator
First posted
Sep 26, 2025
Start date
Jan 6, 2025
Primary completion
May 30, 2025
Completion
Jun 20, 2025
Last update
Sep 26, 2025

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Sep 2025. You cannot join it, but the record below documents what was studied.

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