An interventional study of Genicular nerve block with prilocaine and genicular nerve block with prilocaine and triamcinolone in Gonarthrosis; Primary, Genicular Nerve Block and Gonarthritis, sponsored by Haydarpasa Numune Training and Research Hospital. Completed at 1 site in Turkey (Türkiye). Open to participants aged 45 Years to 75 Years. Per ClinicalTrials.gov, last updated 2025-11-28.
Sponsored by Haydarpasa Numune Training and Research Hospital · Not applicable, Interventional, and Treatment
The goal of this clinical trial is to evaluate whether genicular nerve block (GNB) is effective in reducing pain in patients with knee osteoarthritis. It will also assess the comparative efficacy of different injection protocols.
The main questions it aims to answer are:
Does genicular nerve block with corticosteroid and local anesthetic provide superior pain relief compared with local anesthetic alone or placebo?
Are there differences in clinical outcomes between the three treatment groups?
Researchers will compare three groups:
GNB with corticosteroid plus local anesthetic
GNB with local anesthetic alone
Sham procedure with saline (placebo control)
Participants will:
Receive the assigned injection protocol in accordance with their group
Be evaluated at baseline and scheduled follow-up visits for pain intensity and functional status
Report their pain scores and functional limitations using standardized assessment tools
3,302 studies on the registry are indexed under Osteoarthritis, Knee; 608 are open to participants now.
This study's enrollment of 81 is above the median of 70 across 2,731 interventional studies indexed under Osteoarthritis, Knee.
Browse Osteoarthritis, Knee studies →Haydarpasa Numune Training and Research Hospital is the lead sponsor of 32 studies on the registry; 6 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Group 1 (GNB with local anesthetic only): Patients received a genicular nerve block (GNB) with 6 mL of 2% prilocaine and participated in a knee exercise program.
Drug: Genicular nerve block with prilocaine
Group 2 (GNB with local anesthetic and corticosteroid): Patients received GNB with 5 mL of 2% prilocaine in combination with 1 mL/40 mg of triamcinolone and followed the same exercise regimen.
Drug: genicular nerve block with prilocaine and triamcinolone
Group 3 (Control group): Patients received a placebo injection (6 mL of 0.9% saline) with the knee exercise program.
Drug: Sham injection
ultrasound guided genicular nerve block (GNB) injecting 6 mL of 2% prilocaine to the genicular nerves
Also known as: group 1
ultrasound guided genicular nerve block (GNB) injecting 5 mL of 2% prilocaine in combination with 1 mL/40 mg of triamcinolone to the genicular nerves
Also known as: group 2
placebo injection using 6 mL of 0.9% saline to knee region other than genicular nerves
Also known as: group 3
Pain intensity
Visual Analog Scale (VAS): The VAS assesses pain intensity on a 10-centimeter scale. Patients indicate their pain levels using two verbal descriptors at the end of each scale.
Time frame: at baseline, 1 week, and 1 month after treatment
Functional status using WOMAC
The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) questionnaire assessed pain and disability.
Time frame: baseline, 1 week, and 1 month after treatment
Functional status using 40-Meter Fast Walking Test
40-Meter Fast Walking Test: This test involved a designated 10-meter walking track. Patients walked at their maximum pace for four laps. No warm-up was conducted, and the time spent turning at the lines was excluded from the calculation
Time frame: at baseline, 1 week, and 1 month after treatment
Pressure Pain Threshold (PPT)
Pressure Pain Threshold (PPT): The Commander Algometer (JTECH Medical, Utah, USA) was utilized to measure PPT at both the medial and lateral sides of the patella. The probe tip of the algometer was applied perpendicularly to the skin, and pressure was gradually increased. Patients indicated when they first experienced discomfort, at which point the measurement was recorded. This procedure was repeated three times, and the average value was noted.
Time frame: baseline, 1 week, and 1 month after treatment
Ultrasound evaluation
Ultrasound measurements were taken to assess patellofemoral cartilage thickness and quadriceps muscle thickness
Time frame: baseline
Plan to share: Undecided — The study data are available with the researcher and can be provided to the relevant authorities if required.
This study is completed, as verified in Nov 2025. You cannot join it, but the record below documents what was studied.
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Haydarpasa Numune Training and Research Hospital