An observational study in Ischemic Stroke, Cardioembolic Stroke and Thrombus, sponsored by Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA). Completed at 1 site in Netherlands. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-01-21.
Sponsored by Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Observational
The aim of the AIS of HEARTS registry is to establish a database to collect, maintain and provide accessible individual patient data from international cohorts and to provide pooled analyses about the yield and value of cardiac computed tomography (CT), acquired during the initial stroke imaging protocol.
The main analysis will investigate the diagnostic yield of cardiac CT to detect cardioembolic sources of stroke in acute ischemic stroke patients.
This study is an individual patient data meta-analysis of four different cohorts (4 hospitals) with both prospective and retrospective data. Patients are included if they underwent cardiac CT (ECG gated or non-ECG gated) acquired during the acute stroke scan protocol. The main paper will focus on the diagnostic yield of cardiac thrombi detected on cardiac CT acquired during the acute stroke scan protocol, the comparison with echocardiography and the 90 day follow-up outcomes.
Prospectively planned subanalyses from the AIS of HEARTS registry:
Beyond the analyses focussed on cardiac thrombi, the investigators have prespecified the following analyses:
40 studies on the registry are indexed under Embolic Stroke; 11 are open to participants now.
This study's enrollment of 3,940 is above the median of 364 across 27 observational studies indexed under Embolic Stroke.
Browse Embolic Stroke studies →Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) is the lead sponsor of 532 studies on the registry; 183 are open to participants now.
Compared within Embolic Stroke, this study's primary condition as ClinicalTrials.gg classifies it; the registry's first condition term is Ischemic Stroke. The counts are of registry records indexed under each term, refreshed daily. How we classify →
Patients 18 years or older with acute ischemic stroke that underwent a cardiac CT during the acute stroke scanprotocol.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
A “mini-stroke”: temporary stroke-like symptoms caused by reduced blood flow to part of the brain, spinal cord or eye, without signs of a new stroke on a scan.
Stroke symptoms need emergency care at once, even if they go away.
TIA (transient ischaemic attack)
A “mini-stroke”: temporary stroke-like symptoms caused by reduced blood flow to part of the brain, spinal cord or eye, without signs of a new stroke on a scan.
Stroke symptoms need emergency care at once, even if they go away.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Patients from Amsterdam UMC that underwent ECG-gated cardiac CT
Patients from Christchurch hospital that underwent non-ECG gated cardiac CT
Patients from John Hunter Hospital that underwent non-ECG gated cardiac CT
Patients from Liverpool Hospital that underwent ECG-gated cardiac CT
Proportion of patients with cardiac thrombus detected on acute cardiac CT.
The proportion of patients with acute ischemic stroke that have a cardiac thrombus detected on cardiac CT.
Time frame: Baseline: the assessment of a cardiac thrombus is performed when the patient arrives at the Emergency Department and undergoes the acute stroke imaging protocol including a cardiac CT.
Comparison between cardiac CT and echocardiography for the detection of cardiac thrombi.
Proportion of acute ischemic stroke patients with a cardiac thrombus on cardiac CT and echocardiography, in patients that underwent both investigations.
Time frame: An average of within 1 year: the investigators include echocardiography that is performed in routine stroke clinical care. This means that the time delay is dependent on various aspect of the local center.
Follow up 90 days: mortality compared between patients with and without thrombus
Proportion of patients that died at 90 days follow-up after stroke onset.
Time frame: From stroke onset until 90 days follow-up
Follow-up 90 days: recurrent stroke
Proportion of patients that had a recurrent stroke at 90 days follow-up after stroke onset. A recurrent stroke needs to be clearly defined, based on clinical, imaging and other diagnostic information
Time frame: Stroke onset until 90 days follow-up
Follow-up 90 days: outcome using modified rankin scale score
Functional outcome at 90 days, measured using the modified rankin scale (mRS) score. The mRS score is a scale from 0-6. Higher scores mean a worse functional outcome.
Time frame: Stroke onset until 90 days follow-up
Plan to share: Undecided
This study is completed, as verified in Aug 2025. You cannot join it, but the record below documents what was studied.
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