An interventional study of Cordyceps cicadae and Blank control in Visual Acuity, Accommodation and Dry Eye, sponsored by China Medical University Hospital. Active, not recruiting at 1 site in Taiwan. Open to participants aged 30 Years to 60 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-08-21.
Sponsored by China Medical University Hospital · Not applicable, Interventional, and Supportive care
The objective of this study is to evaluate, through a clinical human consumption trial, the effects of taking two capsules (each containing 250 mg of Cordyceps cicadae mycelium, for a total intake of 500 mg per dose) of Grape King Cordyceps cicadae mycelium on visual function and anti-fatigue performance in esports athletes.
This study aims to enroll 12 participants (aged 20-30 years), who are esports players, through oral announcements for recruitment. The anticipated source of participants will be students from the Department of Multimedia Game Development and Applications, Hungkuang University of Science and Technology, second-year and above.
On the day prior to the trial, participants will undergo a baseline ophthalmic examination (serving as the control values). Following the baseline assessment, participants will undergo ophthalmic examinations after 1 hour and 2 hours of esports training, respectively, resulting in a total of three measurements. All data will be recorded in the case report form (CRF).
On the day of the trial, participants will first undergo an ophthalmic examination. After completion, all 12 participants will be randomly allocated into groups using the QuickCalcs randomization tool (GraphPad Software, https://www.graphpad.com/quickcalcs/randomize1/). Based on the random allocation, capsule packages labeled with codes 001 to 012 will be prepared, containing either the investigational product or placebo. Each package will be distributed to the corresponding participant. Of the 12 participants, 3 will be assigned to the placebo group, and 9 will be assigned to the Cordyceps cicadae mycelium group.
Participants will undergo ophthalmic examinations at 1 hour and 2 hours post-administration, and the results will be recorded in the CRF.
The investigational product will be in capsule form, containing Cordyceps cicadae mycelium (250 mg per capsule) and excipients, with no other additives. The placebo will have the same excipients and capsule composition, except without the mycelium. Each participant will take a single oral dose on the test day (2 capsules). All investigational products and placebos will be provided by Grape King Bio Ltd.
1,292 studies on the registry are indexed under Dry Eye Syndromes; 191 are open to participants now.
This study's enrollment of 12 is below the median of 60 across 1,077 interventional studies indexed under Dry Eye Syndromes.
Browse Dry Eye Syndromes studies →China Medical University Hospital is the lead sponsor of 464 studies on the registry; 116 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Cordyceps cicadae 500mg
Dietary Supplement: Cordyceps cicadae
Placebo
Dietary Supplement: Blank control
Cordyceps cicadae 500mg
Blank control
Tear break-up time
Tear film break-up time (TBUT) on the corneal surface will be recorded in seconds using corneal topography.
Time frame: 3 hours
Eye fatigue questionnaire
The Ocular Surface Disease Index (OSDI) was used to assess visual fatigue. The subjects were asked to fill in the questionnaire before and after taking the medicine, and the scores were calculated. Symptoms include eyestrain, discomfort, burning, irritation, pain, soreness, eye pain, double vision, photophobia, blurriness, itching, tearing, dryness, and foreign body sensation
Time frame: 3 hours
Accommodative Facility
Use +/- 0.50D flip mirror and special optometry cards to test the number of optometry cards that the patient can read within one minute and record the number of flip cycles.
Time frame: 3 hours
Visual acuity measurement
Examinations include (a) distance visual acuity (DVA) and (b) near visual acuity (NVA), recorded using the Snellen chart.
Time frame: 3 hours
Intraocular Pressure
The intraocular pressure (IOP) of the subjects was measured by non-contact intraocular pressure measurement in mmHg.
Time frame: 3 hours
Tear meniscus height (TMH)
Tear meniscus height (TMH) will be evaluated using slit-lamp biomicroscopy and recorded in millimeters.
Time frame: 3 hours
Meibomian gland observation
The meibomian glands will be evaluated using corneal topography to document their morphology, quantity, and size.
Time frame: 3 hours
Plan to share: No — This experiment involves patents and intellectual property rights
No publications or documents are linked to this record.
This study is active, not recruiting, as verified in Aug 2025. You cannot join it, but the record below documents what was studied.
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China Medical University Hospital