An interventional study of Thiol- Disulfide Blood Sample Measurement in Sepsis and Oxidative Stress, sponsored by Sakarya University. Completed at 1 site in Turkey (Türkiye). Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-08-21.
Sponsored by Sakarya University · Not applicable, Interventional, and Diagnostic
The aim of this study was to determine the effectiveness of thiol-disulfide homeostasis in predicting diagnosis and mortality in sepsis patients, and to compare it with other inflammatory markers.
Sepsis is a serious illness with high mortality rates triggered by infection-associated pathogenesis involving oxidative stress dysfunction. This study aims to elucidate the diagnostic efficacy of changes in thiol-disulfide homeostasis, its predictive role in mortality, relationship with other inflammatory parameters in sepsis patients in emergency department.
In prospective, randomized controlled study, 50 patients diagnosed with sepsis according to the Sepsis-3 guidelines who presented emergency department were compared with a control group of 50 healthy volunteers. Thiol-disulfide homeostasis parameters, including total thiol, native thiol, disulfide levels, reduced thiol, oxidized thiol, and thiol oxidation-reduction ratios, were examined. Additionally, inflammatory blood parameters (C-reactive protein, procalcitonin, lactate) and mortality durations were compared with thiol-disulfide homeostasis.
The objective of this study was to examine the effectiveness of thiol-disulfide homeostasis in forecasting diagnosis and mortality in sepsis patients, and to compare it against other inflammatory markers.
1,899 studies on the registry are indexed under Sepsis; 462 are open to participants now.
This study's enrollment of 100 is close to the median of 105 across 896 interventional studies indexed under Sepsis.
Browse Sepsis studies →Sakarya University is the lead sponsor of 178 studies on the registry; 48 are open to participants now.
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Exclusion Criteria:
Consisted of patients diagnosed with sepsis (defined as those presenting to the emergency department with suspected infection and scoring two or higher on the quick Sequential Organ Failure Assessment scoring system according to the Sepsis-3 guidelines) and who agreed to participate in the study.
Diagnostic Test: Thiol- Disulfide Blood Sample Measurement
Comprised of healthy volunteers who presented to the emergency department for any reason and agreed to participate in the study.
Measurement of thiol-disulfide homeostasis parameters and inflammatory markers from serum samples.
Diagnostic value of serum thiol-disulfide homeostasis parameters in sepsis
Measurement of serum total thiol, native thiol, disulfide, reduced thiol, and oxidized thiol levels in patients with sepsis and healthy controls at the time of admission, and comparison between groups to evaluate diagnostic performance.
Time frame: 2 monhts
General Characteristics of All Participants
Demographic data (age, gender, body mass index) were recorded.
Time frame: 1 week
Correlation of inflammatory and biochemical markers with thiol-disulfide homeostasis in sepsis
Initial blood samples collected from sepsis patients were analyzed to measure total thiol, native thiol, disulfide, reduced thiol, and oxidized thiol levels. These thiol-disulfide homeostasis parameters were then compared and correlated with standard laboratory inflammatory markers, including C-reactive protein (CRP), procalcitonin, and lactate, to evaluate their relationships.
Time frame: 10 days
Plan to share: No
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This study is completed, as verified in Aug 2025. You cannot join it, but the record below documents what was studied.
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Sakarya University