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RecruitingNCT07109765Updated Aug 7, 2025

Secukinumab Treatment for Moderate to Severe Hidradenitis Suppurativa

An observational study in Hidradenitis Suppurativa (HS), sponsored by Peking Union Medical College. Recruiting at 1 site in China. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-08-07.

Sponsored by Peking Union Medical College · Observational

From the registry’s dates

  • Primary completion was expected by Jun 2026, 4 months ago, but the record still lists the study as recruiting.
  • Started Jun 2025; still recruiting 1 year 4 months later.
Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
50
Ages
18 Years and older
Sex
All
01

Study summary

This single-center, prospective, observational study aimed to evaluate the efficacy and safety of Secukinumab in treating moderate-to-severe hidradenitis suppurativa (HS). The study was conducted from June 1, 2025, to June 1, 2026, and all participants were treated at the Department of Dermatology, Peking Union Medical College Hospital. The study was approved by the Clinical and Research Ethics Committee of the Chinese Academy of Medical Sciences, Peking Union Medical College Hospital (Ethics Approval No. I-24PJ1844). All procedures involving human participants adhered to the Declaration of Helsinki. Written informed consent form was signed and obtained from the participant.

02

Conditions studied

  • Hidradenitis Suppurativa (HS)

Keywords

  • Hidradenitis Suppurativa
  • Secukinumab
  • ultrasound
03

In context

Hidradenitis Suppurativa

277 studies on the registry are indexed under Hidradenitis Suppurativa; 88 are open to participants now.

This study's planned enrollment of 50 is below the median of 142 across 69 observational studies indexed under Hidradenitis Suppurativa.

Browse Hidradenitis Suppurativa studies →

Lead sponsor

Peking Union Medical College is the lead sponsor of 58 studies on the registry; 17 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Sampling method
Non-probability sample

Study population

All participants were treated at the Department of Dermatology, Peking Union Medical College Hospital

Inclusion criteria

  • age ≥18 years
  • diagnosis of moderate-to-severe HS with Hurley stage II or III
  • Disease duration of ≥6 months, presence of at least one draining tunnel or two inflammatory nodules
  • inadequate response to prior treatments, such as antibiotics, isotretinoin, or TNF inhibitors

Exclusion criteria

Exclusion Criteria:

  • active infections (e.g., viral hepatitis, active tuberculosis)
  • use of other biologics or systemic immunosuppressants within the past three months
  • severe organ dysfunction (e.g., hepatic or renal failure)
  • any other conditions that might affect study results
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Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
50 participants (estimated)
Patient registry
No

Interventions

  • DrugSecukinumab

    secukinumab 300 mg weekly for five weeks, followed by 300 mg monthly subcutaneous injection

06

What researchers measure

Primary outcomes

  1. Hidradenitis Suppurativa Clinical Response 50 (HiSCR50)

    a ≥50% reduction in the combined count of inflammatory nodules and abscesses from baseline, without an increase in the number of abscesses or draining tunnels

    Time frame: From enrollment to the end of treatment at Week 12

Secondary outcomes

  1. Dermatology Life Quality Index

    Time frame: From enrollment to the end of treatment at week 12

07

Study locations

1 of 1 sites recruiting
  • No. 1 Shuai Fu Yuan, Dongcheng District, Beijing
    Beijing, Beijing Municipality 100730, China
    Recruiting
08

References and documents

Study documents

  • Study protocol · Jun 30, 2025

Documents are hosted by the registry — open the source record to download them.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Aug 7, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT07109765
Lead sponsor
Peking Union Medical College
Responsible party
Xiao Ma (Resident physician of dermatology, Peking Union Medical College) — Principal investigator
First posted
Aug 7, 2025
Start date
Jun 1, 2025
Primary completion
Jun 1, 2026 (estimated)
Completion
Jun 1, 2026 (estimated)
Last update
Aug 7, 2025
View the source record on ClinicalTrials.gov ↗

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