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Enrolling by invitationNCT07107815Updated Aug 6, 2025

A Study On The Prediction of Neoadjuvant Efficacy For Rectal Cancer Based On MR Cytometry Imaging and Deep-radiomics

An observational study in Rectal Cancer, Adenocarcinoma, sponsored by Cancer Institute and Hospital, Chinese Academy of Medical Sciences. Enrolling by invitation at 1 site in China. Per ClinicalTrials.gov, last updated 2025-08-06.

Sponsored by Cancer Institute and Hospital, Chinese Academy of Medical Sciences · Observational

Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
250
Sex
All
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Study summary

This study employed MR cytometry imaging combined with deep-radiomic research methods to predict the heterogeneity of rectal cancer, and constructed a model to predict the sensitivity to neoadjuvant therapy and potential mechanisms, assisting clinicians in early identification of high-risk tumors and patients with treatment-susceptible rectal cancer, and selecting individualized treatment plans, thereby improving patient prognosis. To this end, the investigators need to collect the clinical diagnosis and treatment data of patients, surgical and biopsy pathological information, pre-treatment rectal MRI images and colonoscopy biopsy tissue sections, and follow up on the surgical pathological results and recurrence of patients. This study is a non-interventional diagnostic study, which does not interfere with the routine diagnosis and treatment of patients, does not affect any medical rights of patients, and does not increase any medical risks.

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Conditions studied

  • Rectal Cancer, Adenocarcinoma

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Keywords

  • rectal cancer
  • MR cytometry imaging
  • deep-radiomics
  • neoadjuvant therapy
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In context

Rectal Neoplasms

1,762 studies on the registry are indexed under Rectal Neoplasms; 518 are open to participants now.

This study's planned enrollment of 250 is above the median of 160 across 413 observational studies indexed under Rectal Neoplasms.

Browse Rectal Neoplasms studies →

Lead sponsor

Cancer Institute and Hospital, Chinese Academy of Medical Sciences is the lead sponsor of 373 studies on the registry; 270 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
Child (0–17), Adult (18–64), Older adult (65+)
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Probability sample

Study population

Chinese patients diagnosed with rectal cancer through pathological examination

Inclusion criteria

  • Newly diagnosed rectal adenocarcinoma without previous treatment
  • Complete radical surgery in the institute
  • Complete rectal MRI within 2 weeks before surgery

Exclusion criteria

Exclusion Criteria:

  • Concomitant malignancies or systemic disease
  • Inadequate MR image quality for analysis
  • Incomplete clinicopathological data
  • Loss of follow-up
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Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
250 participants (estimated)
Patient registry
No
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What researchers measure

Primary outcomes

  1. Pathological complete response

    Time frame: One month after surgery

  2. Pathological tumor regression grade

    Time frame: One month after surgery

  3. progression-free survival

    Time frame: From date of surgery until the date of first documented progression or date of death from any cause, whichever came first, assessed up to 60 months

Secondary outcomes

  1. Pathological differentiation grade

    Time frame: One month after surgery

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Study locations

1 site
  • Cancer Institute and Hospital, Chinese Academy of Medical Sciences
    Beijing, Beijing Municipality 100021, China
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References and documents

Publications

  • Zhao Q, Shi D, Zhong H, Jin C, Wang Z, Shi Z, Li L, Wang B, Jiang Y, Feiweier T, Xu J, Guo H, Zhang H. The predictive value of MR cytometry in histological differentiation of rectal cancer: an exploratory study. Eur Radiol. 2026 Jun;36(6):5155-5168. doi: 10.1007/s00330-026-12341-w. Epub 2026 Jan 30. PubMed 41617831 ↗
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Aug 6, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT07107815
Lead sponsor
Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Responsible party
Sponsor
First posted
Aug 6, 2025
Start date
Mar 15, 2025
Primary completion
Dec 31, 2027 (estimated)
Completion
Dec 31, 2028 (estimated)
Last update
Aug 6, 2025

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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