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WithdrawnNCT07097974Updated May 13, 2026

Evaluation of the Efficacy of the Composite WM Formula in Body Weight Change

An interventional study of WM formula liquid drink and Placebo in Obesity, sponsored by TCI Co., Ltd.. Withdrawn at 1 site in Taiwan. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-05-13.

Sponsored by TCI Co., Ltd. · Not applicable, Interventional, and Prevention

Why this study was withdrawn
based on an overall assessment of feasibility and strategic considerations
Phase
Not applicable
Study type
Interventional
Enrollment
0
Allocation
Randomized
Ages
18 Years and older
Sex
All
01

Study summary

This study aims to evaluate the effects of the combined formula WM Formula, used as a dietary supplement, with a focus on improvements in glycemic and lipid parameters, body composition, and gut microbiota profiles.

Read the detailed description

This study is a single-center, randomized, double-blind, placebo-controlled human clinical trial designed to evaluate the potential effect of the WM Formula composite supplement on body weight. Eligible participants will be adults aged 18 years or older, screened based on waist circumference or body fat percentage.

Participants will be randomly assigned to one of two groups: one receiving the combined formula WM Formula, and the other receiving a placebo. Each group will take either the WM Formula or placebo, and undergo regular assessments throughout the 4-week study period. Physiological parameters (e.g., height, weight, blood pressure, BMI) and biochemical markers (including liver and kidney function, lipid profile, and blood glucose levels) will be collected at baseline (Week 0), Week 2, and Week 4. In addition, participants will complete appetite assessment questionnaires and other surveys to evaluate changes in appetite and gastrointestinal symptoms.

02

Conditions studied

  • Obesity

Keywords

  • Probiotic
  • Prebiotic
  • Glucagon-like peptide-1 (GLP-1)
  • Blood glucose
  • Insulin
03

In context

Obesity

6,296 studies on the registry are indexed under Obesity; 1,692 are open to participants now.

Browse Obesity studies →

Lead sponsor

TCI Co., Ltd. is the lead sponsor of 60 studies on the registry; 7 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
Yes

Inclusion criteria

  • Adults aged 18 years or older who are willing to sign the informed consent form.
  • Body fat percentage: ≥30% for females and ≥25% for males.
  • Non-pregnant and non-lactating women who agree to use physical contraceptive methods (e.g., condoms, intrauterine devices) throughout the study period.

Exclusion criteria

Exclusion Criteria:

  • Use of GLP-1 receptor agonists approved in Taiwan (e.g., liraglutide, semaglutide, dulaglutide), blood glucose-regulating medications, weight loss-related drugs or functional foods, probiotics, or gastrointestinal health-related supplements or medications within 30 days prior to the start of the study.
  • History of chronic gastrointestinal disorders, seizure disorders or epilepsy, hepatic or renal diseases, malignancies, endocrine disorders, psychiatric illnesses, alcohol or drug abuse, or other major organic diseases based on medical history.
  • History of gastrointestinal surgery, organ transplantation, or other major surgeries.
  • History of hypoglycemia.
  • Known lactose intolerance.
  • Chronic diarrhea.
  • Acute gastroenteritis within 2 weeks prior to study initiation.
  • Known allergy to any ingredient in the investigational product.
  • Employees or immediate family members of TCI Co., Ltd.
05

Study design

Phase
Not applicable
Primary purpose
Prevention
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Double (Participant, Care provider)
Enrollment
0 participants (actual)

Study arms

  • Experimental
    WM formula liquid drink

    WM formula liquid drink, 50 g/glass jar

    Dietary Supplement: WM formula liquid drink

  • Placebo comparator
    Placebo

    The placebo contained the same base ingredients as the WM formula but without the active WM formula component.

    Dietary Supplement: Placebo

Interventions

  • Dietary supplementWM formula liquid drink

    One glass jar (50 g) of the WM formula liquid drink was administered once daily, 1 hour prior to the first meal of the day.

  • Dietary supplementPlacebo

    One glass jar (50 g) of the placebo liquid drink was administered once daily, 1 hour prior to the first meal of the day.

06

What researchers measure

Primary outcomes

  1. Change from baseline in weight at weeks 2 and 4

    Assessment of changes in weight at baseline, week 2, and week 4

    Time frame: Week 0, 2 and 4

  2. Change from plasma GLP-1 concentration (pmol/L) in baseline at weeks 2 and 4

    Time frame: Assessment of changes in GLP-1 concentration at baseline, week 2, and week 4

  3. Change from baseline in blood glucose at weeks 2 and 4

    Assessment of blood glucose changes at weeks 0, 2, and 4

    Time frame: Week 0, 2 and 4

Secondary outcomes

  1. Change from plasma DPP-4 concentration (ng/mL) in baseline at weeks 2 and 4

    Assessment of plasma DPP-4 concentration changes at weeks 0, 2, and 4

    Time frame: Week 0, 2 and 4

  2. Change from plasma PAI-1 concentration (ng/mL) in baseline at weeks 2 and 4

    Assessment of plasma PAI-1 concentration changes at weeks 0, 2, and 4

    Time frame: Week 0, 2 and 4

07

Study locations

1 site
  • TCI Co., Ltd.
    Taipei, Taiwan
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on May 13, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT07097974
Lead sponsor
TCI Co., Ltd.
Responsible party
Sponsor
First posted
Aug 1, 2025
Start date
Aug 30, 2025
Primary completion
Nov 30, 2025
Completion
Dec 30, 2025
Last update
May 13, 2026

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is withdrawn, as verified in May 2026. You cannot join it, but the record below documents what was studied.

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