A Phase 4 interventional study of Live Attenuated Influenza Vaccine in Impact of Vaccination, sponsored by University of Maryland, Baltimore. Not yet recruiting at 1 site in United States. Open to participants aged 2 Years to 89 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-09-03.
Sponsored by University of Maryland, Baltimore · Phase 4, Interventional, and Basic science
The research of the investigators is focused on the understanding how the immune system functions and responds to intranasal vaccines. Intranasal vaccines do not lead to the same changes in the blood that intramuscular vaccines do. Therefore, the investigators want to look at the function of immune (lymphoid) organs that are near the nose. The closest immune organs are the adenoids and tonsils. Mice do not have tonsils allowing for the investigators to answer these questions. Human lymphoid tissue will allow the investigators to better understand the molecular behavior of these cells in humans.
The purpose of this protocol is to administer the FDA approved live attenuated influenza vaccine or no vaccine to patients undergoing adenoidectomy and/or tonsillectomy for obstructive sleep apnea prior to surgery and then collect the tissue (adenoid and/or tonsil tissue) that would normally be discarded from surgery. This will allow for improved understanding of what happens after vaccination.
University of Maryland, Baltimore is the lead sponsor of 687 studies on the registry; 130 are open to participants now.
Of its 90 completed or terminated interventional studies of FDA-regulated products, 63 (70%) have results posted.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Intranasal Flu Vaccine
Biological: Live Attenuated Influenza Vaccine
No Intervention
Nasal spray
Serological outcomes will be compared before and after vaccination and between groups.
The comparisons will specifically compare: Mean HAI Ab titers in serum and mucosal secretions
Time frame: From enrollment to 4 weeks after surgery is completed
Hemagglutinin Levels
Mean HA IgG and IgA titers in serum and mucosal secretions
Time frame: From enrollment to 4 weeks after surgery
Neuraminidase Levels
Mean NA IgG and IgA titers in serum and in mucosal secretions
Time frame: From enrollment to 4 weeks after surgery
Influenza Specific Antibodies
Non-neutralizing influenza-specific antibody titers before and after vaccination
Time frame: From enrollment to 4 weeks after surgery
Seroconversion rats
Comparison of serconversion rates
Time frame: From enrollment to 4 weeks post surgery
This study is not yet recruiting, as verified in Aug 2026. You cannot join it, but the record below documents what was studied.
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University of Maryland, Baltimore