An observational study in One-lung Ventilation (OLV), Low-flow Anesthesia and Thoracic Surgery, sponsored by Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital. Completed at 1 site in Turkey (Türkiye). Open to participants aged 18 Years to 75 Years. Per ClinicalTrials.gov, last updated 2025-10-02.
Sponsored by Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital · Observational
This prospective observational study aims to evaluate the effects of low-flow sevoflurane anesthesia on respiratory mechanics, gas exchange, and postoperative pulmonary function in patients undergoing one-lung ventilation (OLV) during thoracic surgery. The study will compare patients receiving low-flow sevoflurane anesthesia with those receiving standard-flow anesthesia, focusing on parameters such as lung compliance, arterial oxygen levels (PaO₂), and postoperative oxygen requirements.
Fifty patients scheduled for elective thoracic surgery with OLV will be included. Data will be collected intraoperatively and postoperatively, and standard anesthesia protocols will be followed according to the attending anesthesiologist's preference. The results are expected to provide new insights into the safety and efficacy of low-flow anesthesia protocols in thoracic surgery, potentially guiding future clinical practice to reduce postoperative pulmonary complications.
One-lung ventilation (OLV) is a common technique used during thoracic surgery to optimize the surgical field and improve operative conditions. However, OLV is associated with potential complications such as hypoxemia, lung collapse, and inflammatory responses. The choice of anesthesia technique plays a critical role in minimizing these adverse effects.
Low-flow anesthesia (LFA), defined as the administration of inhalational anesthetics with a fresh gas flow rate of 1 L/min or less, offers several advantages, including reduced anesthetic consumption, better humidification of inspired gases, decreased heat loss, and more stable pulmonary gas exchange. Despite these benefits, concerns remain regarding the risk of hypoxemia and the need for careful monitoring of anesthesia depth during LFA.
This prospective, single-center, observational study will investigate the effects of low-flow sevoflurane anesthesia on respiratory mechanics, gas exchange, and postoperative pulmonary function in patients undergoing OLV for elective thoracic surgery. Patients will be allocated to either low-flow or standard-flow anesthesia groups based on routine clinical practice, without randomization. Standard anesthesia and ventilation protocols will be applied according to the attending anesthesiologist's preference.
Primary outcomes include intraoperative lung compliance, arterial oxygenation (PaO₂), and postoperative oxygen requirements. Secondary outcomes include the incidence of atelectasis, anesthetic gas consumption, and hemodynamic parameters. Data will be collected during both intraoperative and postoperative periods. The study aims to enroll 50 patients (25 per group), as determined by power analysis.
The findings of this study are expected to provide comprehensive data on the impact of low-flow sevoflurane anesthesia during OLV, particularly regarding respiratory mechanics and postoperative pulmonary function. These results may contribute to the development of safer and more effective anesthesia protocols for thoracic surgery patients.
Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital is the lead sponsor of 73 studies on the registry; 19 are open to participants now.
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Adult patients aged 18 to 75 years who are scheduled for elective video-assisted thoracoscopic surgery (VATS) or thoracotomy under general anesthesia with one-lung ventilation at Dr. Abdurrahman Yurtaslan Oncology Training and Research Hospital. Eligible participants will have ASA physical status I-III and no acute respiratory failure.
Age between 18 and 75 years American Society of Anesthesiologists (ASA) physical status I-III Scheduled for elective video-assisted thoracoscopic surgery (VATS) or thoracotomy No acute respiratory failure
Exclusion Criteria:
Severe chronic obstructive pulmonary disease (COPD) or restrictive lung disease Body mass index (BMI) greater than 40 kg/m² Cardiac dysfunction with ejection fraction (EF) less than 40% Requirement for emergency thoracic surgery
Patients receiving low-flow sevoflurane anesthesia during one-lung ventilation
Patients receiving standard-flow sevoflurane anesthesia during one-lung ventilation
Postoperative Oxygen Requirement
Time frame: 24-hour postoperative period
Static Lung Compliance
Static lung compliance (Cstat) will be calculated using the formula: Cstat = VT / (Pplateau - PEEP), where VT is tidal volume, Pplateau is plateau pressure, and PEEP is positive end-expiratory pressure
Time frame: Intraoperative period
Arterial Oxygen Pressure (PaO₂)
Arterial oxygen pressure (PaO₂) will be measured from arterial blood gas analysis during one-lung ventilation
Time frame: Intraoperative period
Plan to share: No
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This study is completed, as verified in Sep 2025. You cannot join it, but the record below documents what was studied.
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Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital