An observational study in Hypermobility, Joint, sponsored by Hacettepe University. Completed at 1 site in Turkey (Türkiye). Open to participants aged 18 Years to 65 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-07-24.
Sponsored by Hacettepe University · Observational
Background: The volar plate (VP) is a key stabilizer of the proximal interphalangeal joint (PIPJ), and its biomechanical behavior may be altered in individuals with joint hypermobility.
Objective: This study aimed to evaluate the spatial dynamics of the VP and its relationship with the center of joint motion and flexor digitorum profundus (FDP) tendon in individuals with and without joint hyperlaxity using MRI.
Methods: Thirty-two healthy volunteers (16 hyperlax, 16 controls) underwent MRI imaging of both index fingers at five flexion angles (0°, 30°, 60°, 90°, full flexion) and under passive and isometric loading conditions. Key parameters measured included distances from the joint center to VP attachments, VP-FDP tendon distance, and the length between VP ends.
115 studies on the registry are indexed under Joint Instability; 21 are open to participants now.
This study's enrollment of 32 is below the median of 60 across 54 observational studies indexed under Joint Instability.
Browse Joint Instability studies →Hacettepe University is the lead sponsor of 1,007 studies on the registry; 214 are open to participants now.
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Healthy and hypermobility volunteers
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Exclusion Criteria:
The Distance Between the Center of Motion (CoM) and the VPLip and VPTip
The distances between the center of motion (CoM) and the volar lip of the middle phalanx base (VPLip), and between the CoM and the proximal end of the volar plate at its attachment to the volar base of the proximal phalanx (VPTip), were measured using RadiAnt DICOM Viewer software (version 2024.1) in various PIPJ angles.
Time frame: baseline
The Distance Between VPLip and VPTip
The distance between the volar lip of the middle phalanx base (VPLip), and the proximal end of the volar plate at its attachment to the volar base of the proximal phalanx (VPTip) measured using RadiAnt DICOM Viewer software (version 2024.1) in various PIPJ angles. The purpose of this measurement was to observe how the distance between the two ends of the volar plate changes with varying joint angles.
Time frame: baseline
The Distance Between Volar Plate (VP) and FDP Tendon
The distance between the midpoint of the volar plate (VP) and the flexor digitorum profundus (FDP) tendon was measured using RadiAnt DICOM Viewer software (version 2024.1) at various proximal interphalangeal joint (PIPJ) angles. The purpose of this measurement was to observe how this distance changes across different flexion angles.
Time frame: baseline
Changes Observed During Grasping and Isometric Contraction
Measurements at all flexion angles were conducted under two conditions: while passively grasping a cylindrical object (without force) and during isometric contraction (with force).
Time frame: baseline
Plan to share: Undecided — It can not be ethical.
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This study is completed, as verified in May 2025. You cannot join it, but the record below documents what was studied.
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