An observational study in Acute Myeloid Leukemia and NPM1 Mutation, sponsored by Gruppo Italiano Malattie EMatologiche dell'Adulto. Recruiting at 1 site in Italy. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-06-22.
Sponsored by Gruppo Italiano Malattie EMatologiche dell'Adulto · Observational
This is a multicenter observational study with a retrospective and a prospective cohort investigating clinically and biologically the APL-like subset as a potential predictor of coagulopathy and susceptibility to early vascular events.
This is a multicenter observational study with a retrospective and a prospective cohort investigating clinically and biologically the APL-like subset as a potential predictor of coagulopathy and susceptibility to early vascular events.
Participating Centers will identify NPM1-mutated patients eligible for enrollment. The immune-phenotypic data will be evaluated to define a specific signature to be applied for the identification of APL-like AML.
All patients will be followed for a minimum of 12 months until the study closure.
The study cohort will include NPM1mut AML patients with an immunophenotypic characterization at diagnosis that allows the classification into APL-like and non-APL-like AML.
Exclusion Criteria:
NPM1 AML patients identified as APL-like cohort
Other: observation of incidence of early vascular events
NPM1 AML patients identified as no APL-like cohort
Other: observation of incidence of early vascular events
observation of difference incidence of early vascular events in the two cohorts
Incidence of early vascular events
Evaluation of the incidence of early vascular events (haemorrhagic and/or thrombotic) in the APL-like and non-APL-like subsets.
Time frame: 30 days from diagnosis
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Gruppo Italiano Malattie EMatologiche dell'Adulto