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WithdrawnNCT07075627Updated Aug 4, 2026

A Study to Evaluate the Incidence of Clinically Suspicious Lambert-Eaton Myasthenic Syndrome (LEMS) in Subjects Diagnosed With Small Cell Lung Cancer (SCLC)

An observational study in Small Cell Lung Cancer ( SCLC ) and Lambert Eaton Myasthenic Syndrome (LEMS), sponsored by Addario Lung Cancer Medical Institute. Withdrawn at 1 site in United States. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-08-04.

Sponsored by Addario Lung Cancer Medical Institute · Observational

Why this study was withdrawn
Sponsor/Funder decision
Study type
Observational
Model
Case-only
Time perspective
Cross-sectional
Enrollment
0
Ages
18 Years and older
Sex
All
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Study summary

This is a multi-center observational study in subjects with a diagnosis of small cell lung cancer. Screening and/or medical record review for symptoms associated with Lambert Eaton Myasthenic Syndrome (LEMS) will be conducted.

Read the detailed description

This is a multi-center observational study in subjects with a diagnosis of small cell lung cancer. All eligible subjects enrolled will undergo a brief, symptom directed neurological evaluation and VGCC antibody testing (to be performed at a participating Quest laboratory). The results (positive/negative) of VGCC antibody testing will be documented as well as the receptor type P, Q or N.

These tests will be repeated quarterly (Q3 months) for the duration of the study.

If at any visit the subject is found to be BOTH neurologically suggestive of having LEMS and the VGCC Ab test is positive, then the subject is considered to be Clinically Suspicious of having LEMS. At any visit if a subject meets the criteria of Clinically Suspicious of LEMS. the end of study visit will be completed. Once the End of study visit is completed no further treatment information will be collected.

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Conditions studied

  • Small Cell Lung Cancer ( SCLC )
  • Lambert Eaton Myasthenic Syndrome (LEMS)

Keywords

  • SCLC
  • LEMS
  • small cell lung cancer
  • lambert eaton myasthenic syndrome
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In context

Small Cell Lung Carcinoma

1,203 studies on the registry are indexed under Small Cell Lung Carcinoma; 342 are open to participants now.

Browse Small Cell Lung Carcinoma studies →

Lead sponsor

Addario Lung Cancer Medical Institute is the lead sponsor of 10 studies on the registry; none are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

United States

Inclusion criteria

  1. Adult men or women meeting Age of Majority (AOM) at the time of consent
  2. Provide voluntary consent to participate in this study, documented via a signed informed Consent Form (ICF)
  3. Any diagnosis of SCLC
  4. Willing to provide clinical and medical information related to his/her cancer diagnoses to the study team as required
  5. Willing to comply with the requirements of the study

Exclusion criteria

Exclusion Criteria:

  1. Has been diagnosed with non-tumor Lamber-Eaton Myasthenic syndrome (LEMS) > 1 year prior to the SCLC diagnosis.
  2. Known existence of an uncontrolled intercurrent illness including, but not limited to, psychiatric illness or social situations that would impair compliance with study requirements
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Study design

Observational model
Case-only
Time perspective
Cross-sectional
Enrollment
0 participants (actual)
Patient registry
No

Groups and cohorts

  • SCLC

    Diagnosis of SCLC within 1 year of enrollment

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What researchers measure

Primary outcomes

  1. Suspicious LEMS

    Incidence of clinically suspicious LEMS diagnosis

    Time frame: 1 year

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Study locations

1 site
  • Dana-Farber Cancer Institute
    Boston, Massachusetts 02215, United States
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References and documents

Study documents

  • Study protocol · Jun 12, 2025

Documents are hosted by the registry — open the source record to download them.

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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Aug 4, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT07075627
Lead sponsor
Addario Lung Cancer Medical Institute
Responsible party
Sponsor
First posted
Jul 20, 2025
Start date
Sep 2025 (estimated)
Primary completion
Sep 2026 (estimated)
Completion
Dec 2026 (estimated)
Last update
Aug 4, 2026

Study contacts

Jacob Sands, MD
principal investigator · Dana-Farber Cancer Institute
Gilbert Youssef, MD
principal investigator · Dana-Farber Cancer Institute

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is withdrawn, as verified in Aug 2026. You cannot join it, but the record below documents what was studied.

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