An interventional study of Dexametasone and Water for injection in Nerve Condition, sponsored by University of Malaya. Enrolling by invitation at 1 site in Malaysia. Open to participants aged 18 Years to 80 Years. Per ClinicalTrials.gov, last updated 2025-07-16.
Sponsored by University of Malaya · Not applicable, Interventional, and Treatment
The main aim of this study is to elucidate whether the topical irrigation of steroid during thyroid surgery can reduce the rate of recurrent laryngeal nerve palsy as majority of nerve dysfunction was due to neuropraxia to axonotmesis.
Intra-operatively, all participants recruited must have the recurrent laryngeal nerve identify and confirm with Intraoperative Nerve Monitoring (IONM) device.
After removal of thyroid gland, 8mg of dexamethasone will be diluted in 100cc of irrigation water and irrigate the operative field for 1 minute for the intervention group.
However for the placebo group, they will received water irrigation over the operative field only which is the current standard of practice at the moment.
Both the otolaryngologist and patient are blinded throughout the whole study.
University of Malaya is the lead sponsor of 280 studies on the registry; 55 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
For the placebo group, they will received water irrigation over the operative field only which is the current standard of practice at the moment.
Drug: Water for injection
Intra-operatively, all participants recruited must have the recurrent laryngeal nerve identify and confirm with Intraoperative Nerve Monitoring (IONM) device. After removal of thyroid gland, 8mg of dexamethasone will be diluted in 100cc of irrigation water and irrigate the operative field for 1 minute for the intervention group.
Drug: Dexametasone
Intra-operatively, all participants recruited must have the recurrent laryngeal nerve identify and confirm with Intraoperative Nerve Monitoring (IONM) device. After removal of thyroid gland, 8mg of dexamethasone will be diluted in 100cc of irrigation water and irrigate the operative field for 1 minute for the intervention group.
For the placebo group, they will received water irrigation over the operative field only which is the current standard of practice at the moment.
Post thyroidectomy vocal cord assessment will be performed by otolaryngologist within 3 weeks after surgery by using indirect larygoscopy, to look for any vocal cord palsy
if both the vocal cord mobile equally with no phonation gap, indicated no vocal cord palsy if any of the vocal cord paralysed with phonation gap, indicated vocal cord palsy
Time frame: Three week post surgery
Documents are hosted by the registry — open the source record to download them.
Plan to share: No
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University of Malaya