An interventional study of Test Cream in Facial Wrinkles and Rhytides Reduction, sponsored by ChinaNorm. Completed at 1 site in China. Open to female participants aged 20 Years to 50 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-07-16.
Sponsored by ChinaNorm · Not applicable, Interventional, and Treatment
This study aimed to evaluate the short-term efficacy of a facial cream (Formula# 899675 44A) on improving various skin quality and wrinkle parameters after a single application. A total of 44 healthy Chinese women aged 20 to 50 years, with all skin types including 50% sensitive skin, were enrolled. Participants applied the cream once to the full face and neck under supervision, and outcomes were assessed at baseline (T0), 10 hours (T10h), and 24 hours (T24h) post-application. Clinical evaluations and photo-based imaging were used to assess skin plumpness, smoothness, radiance, and multiple types of wrinkles. At the end of the study, 42 participants completed the protocol.
ChinaNorm is the lead sponsor of 24 studies on the registry; 11 are open to participants now.
Counted across the registry records on this site, refreshed daily.
1.Chinese female with 20-50 years old (Must have 20-30 years old). 2.In general, good health at the time of the study. 3.All skin types, with 50% sensitive skin. 4.Regular users for cleanser, anti-aging cream and sunscreen product. 5.Self-declare with plumpness, smoothness and wrinkles problems. 6.Clinical grading by dermatologist in terms of: Underneath eye wrinkles: 2≤grade≤4; Forehead wrinkles: 1 \<grade≤ 4; Crow's feet wrinkles: grade > 1; Skin smoothness: 3≤ grade≤ 6 (0-9 scale); Skin plumpness: 3≤ grade≤ 6 (0-9 scale); 7.Did not participate any clinical test or cosmetic product test on skin within 3 months.
8.Did not participate any chemical/beauty procedures for previous 6 months. 9.No disagreement of dermatologist because of other reasons that exclude the participation of the subject.
10.Were willing and able to participate as evidenced by signing of informed consent and photo release form.
11.Must be willing to comply with all study protocol requirements.
Exclusion Criteria:
1.Pregnant or breast-feeding woman or woman planning pregnancy during the study.
2.Subject deprived of rights by a court or administrative order. 3.Major subject to a guardianship order. 4.Subject residing in a health or social care establishment. 5.Patient in an emergency setting. 6.Subject with a skin disease in the test areas as well as skin allergy (particularly e.g., acne, rosacea, eczema).
7.Subject presenting a stable or progressive serious disease (per investigator's assessment).
8.Immuno-compromised subject. 9.Subject with history of allergy to cosmetic or personal care products or ingredients.
10.Subject presenting excessive exposure to sunlight or UV radiation (investigator's assessment).
11.Subjects regularly practicing aquatic or nautical sports. 12.Subjects regularly attending a sauna. 13.Subject with physical highly sensitive constitution. 14.Subject with cardiovascular or circulatory history. 15.Subject with a history of skin cancer or malignant melanoma. 16.Intake of antihistamines, antibiotics, corticosteroids, non-steroidal anti-inflammatories or immune-suppressants in the last 6 months before study.
Participants applied the test cream (Formula# 899675 44A, 30 mL) once to the full face and neck under staff supervision. Application was followed by massaging designated wrinkle-prone areas including the forehead, crow's feet, underneath eyes, nasolabial folds, and neck folds. Clinical assessments and imaging analysis were performed at T0, T10h, and T24h post-application.
Other: Test Cream
A facial cream (Formula# 899675 44A, 30 mL) was applied once by participants under supervision. 1g of cream was spread over the entire face and neck, followed by targeted massage on wrinkle-prone areas including forehead, crow's feet, underneath eyes, nasolabial folds, and neck folds. Clinical and photo-based evaluations were conducted at baseline (T0), 10 hours (T10h), and 24 hours (T24h) after application.
Time effect of cheek plumpness (Visual)
Time frame: Compare to baseline, Time point at 10 hours, Time point at 24 hours.
Time effect of skin smoothness (Visual)
Time frame: Compare to baseline, Time point at 10 hours, Time point at 24 hours.
Time effect of skin radiance (Visual)
Time frame: Compare to baseline, Time point at 10 hours, Time point at 24 hours.
Time effect of skin elasticity (Tactile)
Time frame: Compare to baseline, 10h, 24h
Time effect of global fine lines (Visual)
Time frame: Compare to baseline, Time point at 10 hours, Time point at 24 hours.
Time effect of forehead wrinkles (Photo analysis)
Time frame: Compare to baseline, Time point at 10 hours, Time point at 24 hours.
Time effect of crow's feet wrinkles (Photo analysis)
Time frame: Compare to baseline, Time point at 10 hours, Time point at 24 hours.
Time effect of skin firmness (Visual)
Time frame: Compare to baseline, Time point at 10 hours, Time point at 24 hours.
Time effect of nasolabial folds (Photo analysis)
Time frame: Compare to baseline, Time point at 10 hours, Time point at 24 hours.
Time effect of skin hydration (Corneometer)
Time frame: Compare to baseline, Time point at 10 hours, Time point at 24 hours.
Time effect of skin TEWL (Tewameter)
Time frame: Compare to baseline, Time point at 10 hours, Time point at 24 hours.
Time effect of skin glossiness (Glossymeter)
Time frame: Compare to baseline, Time point at 10 hours, Time point at 24 hours.
Time effect of skin redness (Chromameter)
Time frame: Compare to baseline, Time point at 10 hours, Time point at 24 hours.
Plan to share: Yes — This Data Sharing Plan (DSP) aims to promote the open exchange and reuse of de-identified individual participant data (IPD) from cosmetic clinical research, including study protocols, case report forms (CRFs), and statistical analysis plans (SAPs). The shared data will be made available through compliant platforms to eligible researchers in dermatology, cosmetic science, and related fields, following ethical principles and data protection regulations. Users must sign a Data Use Agreement (DUA) to ensure data security, privacy protection, and compliance with research purposes.
Supporting information: Study protocol, Sap, Icf, Csr, Analytic code
No publications or documents are linked to this record.
This study is completed, as verified in Jul 2025. You cannot join it, but the record below documents what was studied.
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