An interventional study of postural drainage with ACBT and flutter with ACBT in Cystic Fibrosis, sponsored by Riphah International University. Not yet recruiting at 1 site in Pakistan. Open to participants aged 16 Years to 40 Years. Per ClinicalTrials.gov, last updated 2025-07-14.
Sponsored by Riphah International University · Not applicable, Interventional, and Treatment
This study will help to establish evidence-based physiotherapy on postural drainage and ACBT against flutter with ACBT is better to improve sleep quality, adherence, dyspnea in patients with cystic fibrosis and which method can improve respiratory function, reduce the risk of complications after illness and additionally advancements in respiratory therapy can lead to improve sleep quality, individual preference and adherence and dyspnea.
Cystic fibrosis (CF) is a genetic disorder that leads to the accumulation of thick mucus in the lungs and other organs, resulting in recurrent infections and progressive lung damage. This condition is due to mutations in the cystic fibrosis transmembrane conductance regulator CFTR gene, which governs the transport of chloride and other ions across cell membranes. CF affects a significant number of people worldwide, with certain genetic mutations leading to more severe manifestations of the disease. The management of CF is centered on clearing the airways of mucus to prevent infections and slow the progression of lung damage. Various studies have yielded inconsistent results regarding the comparative effectiveness of manual versus mechanical airway clearance techniques in improving pulmonary function tests (PFTs) in CF patients.
Despite the existing literature on postural drainage with ACBT in patient with cystic fibrosis, there is a significant research gap regarding the flutter and ACBT on the bases of outcomes in cystic fibrosis. Most studies have not adequately addressed the distinct needs and responses of flutter with ACBT on the basis of outcomes, leaving a void in understanding how these two intervention effect on sleep, adherence and dyspnea in the context of patients with cystic fibrosis. Closing this gap is essential for developing evidence-based and pulmonary rehabilitation techniques for this specific patient group.
1,581 studies on the registry are indexed under Cystic Fibrosis; 190 are open to participants now.
This study's planned enrollment of 52 is above the median of 36 across 1,034 interventional studies indexed under Cystic Fibrosis.
Browse Cystic Fibrosis studies →Riphah International University is the lead sponsor of 2,133 studies on the registry; 633 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
postural drainage and active cycle breathing technique for 2 times a day for 30 min for 4 weeks
Other: postural drainage with ACBT
active cycle breathing technique with flutter for 30 min for 4 week and 2 times a day
Other: flutter with ACBT
postural drainage and ACBT for 2 times a day for 30 min for 4 weeks.
flutter with active cycle breathing technique for 30 min. for 4 week and 2 times a day.
The Pittsburgh Sleep Quality Index (PSQI)
This is a self-rated questionnaire which assesses sleep quality and disturbances over a 1-month time interval, show the sleep quality duration and efficacy. Many of the aforementioned research employed the PSQI, the most commonly utilized sleep quality index. the validity and reliability of the PSQI in healthcare professionals, or even in high-pressure shift employees. The PSQI's validity and reliability in regularly planned, low-pressure groups, such as adults in good health who live in the vicinity, differed greatly from front-line COVID-19 healthcare personnel. The conventional test theory (CTT) serves as the primary foundation for the reliability and validity research on PSQI. While there is little to no link between the PSQI and problems including anger, nausea,stiffness, and urinary disorder, it does have a strong correlation with the Insomnia Severity Index, polysomnography, and other sleep quality indicators
Time frame: 4 weeks
The Shwachman-Kulczycki score
This is the first scoring system used in cystic fibrosis to assess disease severity and show the adherence to treatment. In the present study, the total Shwachman-Kulczycki score correlated positively with the scores for each of its four domains, and physical activity was the aspect that most influenced total score.
Time frame: 4 weeks
Borg dyspnea scale
The instruments provide a standard method for patients to select ratings of dyspnea on a scale based on descriptors that correspond to specific numbers
Time frame: 4 weeks
The Breathlessness, Cough and Sputum Scale (BCSS)
This scale is used to predict patient exacerbations by evaluating common symptoms, Results suggest BCSS scores are valid indicators of the severity of cough and sputum in patients with COPD. Scores for both items were correlated with sputum volume.
Time frame: 4 weeks
Plan to share: No
This study is not yet recruiting, as verified in Jul 2025. You cannot join it, but the record below documents what was studied.
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Riphah International University