An interventional study of Time-restricted eating and high-intensity interval training in Overweight and Obesity, sponsored by Norwegian University of Science and Technology. Active, not recruiting at 1 site in Norway. Open to participants aged 18 Years to 50 Years. Per ClinicalTrials.gov, last updated 2026-08-13.
Sponsored by Norwegian University of Science and Technology · Not applicable, Interventional, and Treatment
This study will investigate the effects of 12 months periodised time-restricted eating combined with high-intensity interval training compared with a control group on fat mass in adults with overweight/obesity. Participants in the intervention group will complete the intervention remotely and will receive follow-up by telephone. Before randomisation, after 6 months and after 12 months, the investigators will measure the participants' body composition, physical fitness, fasting blood glucose and insulin, blood lipids, and blood pressure. Physical activity, diet, sleep quality, appetite, and adherence to the intervention will also be measured. Secondary sub-analyses of sex differences in the responses to the intervention will be performed.
3,670 studies on the registry are indexed under Overweight; 849 are open to participants now.
This study's planned enrollment of 100 is above the median of 73 across 3,175 interventional studies indexed under Overweight.
Browse Overweight studies →Norwegian University of Science and Technology is the lead sponsor of 487 studies on the registry; 52 are open to participants now.
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Exclusion Criteria:
12 months of periodised time-restricted eating and high-intensity interval training with digital follow-up
Behavioral: Time-restricted eating and high-intensity interval training
No intervention or follow-up. Habitual lifestyle
1-month intense periods of maximal daily eating window of 10 hours and high-intensity interval training (three weekly, unsupervised, aerobic exercise sessions performed at \> 90 % heart rate maximum), separated by 3-month maintenance periods of time-restricted eating on 5 days per week and minimum 1 HIIT session per week. Each exercise session will last for 33-38 minutes. Participants will receive digital follow-up once weekly during intense periods, and once monthly during maintenance periods. The intervention period will be 12 months in total.
Total fat mass
Change in total fat mass measured with bioelectrical impedance analysis
Time frame: From baseline to after 12 months
Blood glucose
Fasting concentration of plasma glucose
Time frame: From baseline to after 6 months and after 12 months
Total fat mass
Change in total fat mass measured with bioelectrical impedance analysis
Time frame: From baseline to after 6 months
Insulin
Fasting concentration of plasma insulin C-peptide
Time frame: From baseline to after 6 months and after 12 months
Average glucose levels
Glycated haemoglobin (HbA1c)
Time frame: From baseline to after 6 months and after 12 months
Blood cholesterol
Total fasting cholesterol in blood
Time frame: From baseline to after 6 months and after 12 months
LDL-cholesterol
Fasting low-density lipoprotein-cholesterol in blood
Time frame: From baseline to after 6 months and after 12 months
HDL-cholesterol
Fasting high-density lipoprotein-cholesterol in blood
Time frame: From baseline to after 6 months and after 12 months
Triglycerides
Fasting triglycerides in blood
Time frame: From baseline to after 6 months and after 12 months
Cardiorespiratory fitness
Peak oxygen uptake at a maximum effort test, measured in mL/min/kg and L/min
Time frame: From baseline to after 6 months and after 12 months
Insulin sensitivity
Homeostatic model assessment for insulin resistance (HOMA-IR): 1.5 + fasting plasma glucose (mmol/L) x fasting plasma insulin C-peptide (pmol/L)/2800
Time frame: From baseline to after 6 months and after 12 months
Body mass
In kg, estimated with bioelectrical impedance analysis
Time frame: From baseline to after 6 months and after 12 months
Fat-free mass
In kg, estimated with bioelectrical impedance analysis
Time frame: From baseline to after 6 months and after 12 months
Visceral fat area
In cm2, estimated with bioelectrical impedance analysis
Time frame: From baseline to after 6 months and after 12 months
Systolic blood pressure
Average of three measurements during rest in seated position, in mmHg
Time frame: From baseline to after 6 months and after 12 months
Diastolic blood pressure
Average of three measurements during rest in seated position, in mmHg
Time frame: From baseline to after 6 months and after 12 months
Resting heart rate
Average of three measurements during rest in sitting position, in beats/min
Time frame: From baseline to after 6 months and after 12 months
Physical activity levels
International Physical Activity Questionnaire
Time frame: From baseline to after 6 months and after 12 months
Diet intake
3-day diet diaries (two weekdays and one weekend day) with online diet diary.
Time frame: During baseline week, after 4, 13, 30, and 50 weeks.
Sleep quality
The Pittsburgh Sleep Quality Index questionnaire
Time frame: From baseline to after 6 months and after 12 months
Adherence to high-intensity interval training
Number of completed exercise sessions out of those prescribed, in percentage
Time frame: 12 months
Compliance to high-intensity interval training
Exercise intensity measured with pulse sensor. Heart rate percentage of individual heart rate maximum.
Time frame: 12 months
Adherence to time-restricted eating
Average number of days per week a daily eating window of 10 hours or less was achieved
Time frame: During baseline week, after 4, 13, 30, and 50 weeks.
Compliance to time-restricted eating
Average daily eating window, self-reported in hours/day
Time frame: During baseline week, after 4, 13, 30, and 50 weeks.
Perception of intervention and digital follow-up
Qualitative interviews with selected participants to explore barriers and motivators
Time frame: After 12 months
Sex differences
Sub-analyses of sex differences in the effectiveness of the intervention
Time frame: From baseline to after 6 months and after 12 months
Plan to share: Yes — We will make de-identified individual participant data (IPD) collected in the study available to other researchers. We will upload a data set in an open access repository. We will only share IPD that cannot be used to identify individuals.
Supporting information: Study protocol, Sap, Csr, Analytic code
No publications or documents are linked to this record.
This study is active, not recruiting, as verified in Aug 2026. You cannot join it, but the record below documents what was studied.
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Norwegian University of Science and Technology