ClinicalTrials.gg
RecruitingNCT07025668Updated Jun 17, 2025

The Effectiveness of Different Exercise Approaches in Biceps Brachii Long Head Tendinopathy

An interventional study of Eccentric Exercise and Combined Exercise in Sports Physical Therapy and Tendinopathy, sponsored by Hacettepe University. Recruiting at 1 site in Turkey. Open to participants aged 18 Years to 50 Years. Per ClinicalTrials.gov, last updated 2025-06-17.

Sponsored by Hacettepe University · Not applicable, Interventional, and Treatment

From the registry’s dates

  • Primary completion was expected by Oct 2025, 1 year ago, but the record still lists the study as recruiting.
  • Started May 2025; still recruiting 1 year 6 months later.

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Phase
Not applicable
Study type
Interventional
Enrollment
36
Allocation
Randomized
Ages
18 Years to 50 Years
Sex
All
01

Where this study stands

Counted across the records on this site · 2026-11-15

Among 23 studies in Tendinopathy with a site in Turkey — 6 open to participants now, 7 under way, none of them phase 3. Tendinopathy · Turkey.

Planned enrollment
12th of 18
36 · median 42
Started
2025
with 4 others
No phase
18 of 23
5 open now
Registered
13th of 23
by date
Lead sponsor
3 of 23
Hacettepe University

Among the 23 studies in Tendinopathy with a site in Turkey, this one is the 12th largest by planned enrollment of the 18 interventional ones that give a count, is one of 5 that started in 2025, is one of 18 with no phase, and was the 13th registered.

Tendinopathy

397 studies on the registry are indexed under Tendinopathy; 77 are open to participants now.

Browse Tendinopathy studies →

Open to participants now

6 of the 23 studies in Tendinopathy with a site in Turkey are open now. Recruiting first, the newest first:

All 6 open studies →

A study can be open while its sites in Turkey have not opened yet or have stopped. Only those recruiting at a site in Turkey →

Who these studies take

Of the 47 Tendinopathy studies recruiting now, 16 (34%) set no upper age limit and 24 (51%) stop at 75 or younger; 1 takes children under 18; 7 take healthy volunteers.

This study: 18 Years to 50 Years · all sexes · no healthy volunteers.

The full table on the hub →

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02

Study summary

This study was planned to analyze the changes in tendon cross-sectional area and shoulder pain with different exercise approaches applied in biceps brachii long head tendinopathy.

Read the detailed description

There are different conservative treatment options for biceps brachii long head tendinopathy. However, the exercise approaches that can be applied for biceps brachii tendinopathy are not clear in the literature. This study aims to investigate the effectiveness of exercises that include 12 weeks of eccentric training or combined exercise approaches.

03

Conditions studied

  • Sports Physical Therapy
  • Tendinopathy

Keywords

  • biceps brachii
  • tendinopathy
  • tendon cross-sectional area
  • shoulder pain
04

Who can participate

Ages eligible
18 Years to 50 Years
Sexes eligible
All
Accepts healthy volunteers
No

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Having shoulder pain lasting 3 months or more
  • Without a history of surgery, having a diagnosis of shoulder rotator cuff tendinopathy, rotator cuff stage 1-2 tear or subacromial impingement, and having been diagnosed with secondary biceps long head tendinopathy by a physician
  • Pain level during activity > 3 according to the visual analog scale
  • Patients who have been informed about the study and have given written consent to participate in the study will be included in the study.

Exclusion criteria

Exclusion Criteria:

  • Acute shoulder injury
  • History of shoulder and cervical surgery
  • Limitation of passive range of motion
  • History of local injection within the last 12 months
  • Patients who cannot comply with the exercise program will be excluded from the study.
Terms in these criteria, in plain language(1)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

Corticosteroids (steroids)

Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.

Studies differ in what they allow: check which steroid medicines, routes (tablets, injections, creams, inhalers, eye drops) and doses this study accepts.

05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Double (Participant, Outcomes assessor)
Enrollment
36 participants (estimated)

Study arms

  • Active comparator
    Eccentric Exercise Group

    In the eccentric exercise group, in addition to strengthening exercises for the periscapular muscles and stretching exercises for the biceps brachii muscle, eccentric strengthening exercises for the biceps brachii muscle will be given.

    Other: Eccentric Exercise

  • Active comparator
    Combined-Exercise Group

    In the combined exercise group, in addition to strengthening exercises for the periscapular muscles and stretching exercises for the biceps brachii muscle, progressive isometric, isotonic and plyometric strengthening training will be given to the biceps brachii muscle.

    Other: Combined Exercise

  • Active comparator
    Control Group

    In the control group, strengthening exercises for the periscapular muscles and stretching exercises for the biceps brachii muscle will be given. Strengthening exercises for the biceps brachii muscle will not be given in this group.

    Other: Control Group Exercise

Interventions

  • OtherEccentric Exercise

    In the eccentric exercise group, in addition to strengthening exercises for the periscapular muscles and stretching exercises for the biceps brachii muscle, eccentric strengthening exercises for the biceps brachii muscle will be given. Participants will do the exercises in the groups they were randomized to every day for 12 weeks. They will be called to the clinic once a week for exercise checks.

  • OtherCombined Exercise

    In the combined exercise group, in addition to strengthening exercises for the periscapular muscles and stretching exercises for the biceps brachii muscle, progressive isometric, isotonic and plyometric strengthening training will be given to the biceps brachii muscle. Participants will do the exercises in the groups they were randomized to every day for 12 weeks. They will be called to the clinic once a week for exercise checks.

  • OtherControl Group Exercise

    In the control group, strengthening exercises for the periscapular muscles and stretching exercises for the biceps brachii muscle will be given. Strengthening exercises for the biceps brachii muscle will not be given in this group. Participants will do the exercises in the groups they were randomized to every day for 12 weeks. They will be called to the clinic once a week for exercise checks.

06

What researchers measure

Primary outcomes

  1. Tendon Cross-Sectional Area

    Ultrasound will be used to measure tendon cross-sectional area.

    Time frame: Baseline and 12 weeks

Secondary outcomes

  1. Visual Analog Scale (VAS)

    The patient will be asked to mark the severity of his/her pain at rest, at night, and during general activity on a 10 cm line without numbers, and the point they mark will be measured in millimeters with a ruler. The left end of the line indicates no pain, corresponding to 0 cm, while the pain level increases towards the right end of the line, which is marked at 10 cm.

    Time frame: Baseline and 12 weeks

07

Study locations

1 of 1 sites recruiting
08

References and documents

Publications

  • Friedman DJ, Dunn JC, Higgins LD, Warner JJ. Proximal biceps tendon: injuries and management. Sports Med Arthrosc Rev. 2008 Sep;16(3):162-9. doi: 10.1097/JSA.0b013e318184f549. PubMed 18703976 ↗
  • Ahrens PM, Boileau P. The long head of biceps and associated tendinopathy. J Bone Joint Surg Br. 2007 Aug;89(8):1001-9. doi: 10.1302/0301-620X.89B8.19278. PubMed 17785735 ↗
  • Chen RE, Voloshin I. Long Head of Biceps Injury: Treatment Options and Decision Making. Sports Med Arthrosc Rev. 2018 Sep;26(3):139-144. doi: 10.1097/JSA.0000000000000206. PubMed 30059449 ↗
  • Ryu JH, Pedowitz RA. Rehabilitation of biceps tendon disorders in athletes. Clin Sports Med. 2010 Apr;29(2):229-46, vii-viii. doi: 10.1016/j.csm.2009.12.003. PubMed 20226316 ↗

Individual participant data

Plan to share: No

09

Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reachedSimilar studies: half by the dot; the band is the middle halfHalf of similar studies reached it by the dot; the band is the middle half, from a quarter to three quarters

Started May 2025 (actual). Primary completion is estimated for Oct 2025, 5 months after the start.

Of 174 non-industry interventional studies with no phase under Tendinopathy, half reached primary completion within 20 months of starting (the median), counting those still running; a quarter within 7 and three quarters within 37. This study's planned 5 months is below that.

Counting every sponsor, half of 183 studies reached it within 20 months; a quarter within 7 and three quarters within 37.

How these figures are worked out, and which studies are left out of them.

Registered
Jun 5, 2025
First posted
Jun 17, 2025
StartActual
May 9, 2025
Primary completionEst.
Oct 30, 2025
CompletionEst.
Nov 30, 2025
Last update
Jun 17, 2025
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Jun 17, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT07025668
Responsible party
Ebru Gül SEZİK (Principal Investigator, Hacettepe University) — Principal investigator
First posted
Jun 17, 2025
Start date
May 9, 2025
Primary completion
Oct 30, 2025 (estimated)
Completion
Nov 30, 2025 (estimated)
Last update
Jun 17, 2025

Study contacts

Ebru G SEZİK, Msc
Contact
ebrugulozdemiir@gmail.com
05532025875
Ebru G SEZİK, Msc
principal investigator · Hacettepe University

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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