An observational study in Rabies, sponsored by Tanta University. Completed at 1 site in Egypt. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-03-30.
Sponsored by Tanta University · Observational
This study aims to investigate physicians' adherence to Advisory Committee on Immunization Practices (ACIP) guidelines regarding Anti-rabies post-exposure prophylaxis in Egypt.
There is no known effective treatment for rabies, and virtually all cases are fatal. Although the prognosis is poor in patients who develop rabies, the disease is usually preventable with proper wound care and post-exposure prophylaxis. Following a thorough risk assessment, the decision to initiate rabies post-exposure prophylaxis should be made. The risk assessment should consider the type of exposure, local rabies epidemiology in animals, vaccination history of the animal, circumstances of the exposure incident, and the availability of the animal for observation or rabies testing .
The World Health Organization (WHO) and the Advisory Committee on Immunization Practices (ACIP) have adopted guidelines for starting post-exposure prophylaxis (PEP) against rabies. The decision to start Anti-Rabies PEP is usually made in primary health care units or emergency departments .
Lack of adherence to these guidelines might result in unnecessary costs and medical risks, such as injection site reactions and systemic hypersensitivity reactions . This malpractice of inappropriate anti-rabies PEP prescription is not uncommon.
114 studies on the registry are indexed under Rabies; 15 are open to participants now.
Browse Rabies studies →Tanta University is the lead sponsor of 1,010 studies on the registry; 321 are open to participants now.
Of its 15 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.
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This cross-sectional survey study will be conducted on a consecutive sample of physicians who treat patients with animal bites potentially requiring post-exposure anti-rabies prophylaxis. The sample will include emergency physicians, general practice or family physicians, and surgeons of both sexes, with varying degrees of experience and post-graduate clinical training.
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Exclusion Criteria:
This cross-sectional survey study will be conducted on a consecutive sample of physicians who treat patients with animal bites potentially requiring post-exposure anti-rabies prophylaxis. The sample will include emergency physicians, general practice or family physicians, and surgeons of both sexes, with varying degrees of experience and post-graduate clinical training. All participants will consent to submit an anonymous Google Form-based questionnaire. The designed questionnaire will include introductory personal, academic, and work experience data about the physicians as gender, age, specialty, workplace, highest achieved medical-academic or training degree, and number of years of postgraduate clinical work experience. Candidates will be asked to reflect on their pre and postgraduate education/training quality and their confidence level in prescribing anti-rabies post-exposure prophylaxis treatment. (as a linear scale).
Adherence to Anti-rabies PEP Guidelines
This study aims to investigate physicians' adherence to the Advisory Committee on Immunization. Practices (ACIP) guidelines regarding Anti-rabies post-exposure prophylaxis in Egypt. This will be through a score given for the correct response to the case-based questionnaire. This questionnaire include 10 case-based scenarios where anti-rabies post-exposure prophylaxis may or may not be indicated as per ACIP guidelines. True response will be scored 1, wrong response will be scored 0 with maximum total score of 10. Higher score reflects better adherence to guidelines recommendations \& vice versa.
Time frame: 6 months
Health & Economic burden of such malpractice
This study attempts to evaluate the possible economic burden of this expected departure from the standard of care by examining doctors' compliance with appropriate prescription of anti-rabies post-exposure prophylaxis. Economic burden will be calculated by incorporating total odds ratio of inappropriate prescription of anti-rabies vaccine with or without human rabies immunoglobulin , cost of each dose of them to get a rough estimate of the expected cost rising from inappropriate prescription of theses drugs when they are not indicated.
Time frame: 9 months
Plan to share: No
This study is completed, as verified in May 2025. You cannot join it, but the record below documents what was studied.
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