An interventional study of olfactory stimulation and functional MRI in Prader-Willi Syndrome, sponsored by University Hospital, Toulouse. Not yet recruiting at 1 site in France. Open to participants aged 5 Years to 7 Years. Per ClinicalTrials.gov, last updated 2025-06-05.
Sponsored by University Hospital, Toulouse · Not applicable, Interventional, and Other
Among 17 studies in Prader-Willi Syndrome by University Hospital, Toulouse — 6 open to participants now, 6 under way, 1 of them phase 3. Prader-Willi Syndrome · University Hospital, Toulouse.
Among the 17 studies in Prader-Willi Syndrome by University Hospital, Toulouse, this one is the 9th largest by planned enrollment of the 14 interventional ones that give a count, is one of 2 that started in 2025, is one of 6 with no phase, and was the 17th registered.
144 studies on the registry are indexed under Prader-Willi Syndrome; 23 are open to participants now.
Browse Prader-Willi Syndrome studies →6 of the 17 studies in Prader-Willi Syndrome by University Hospital, Toulouse are open now, in 1 country. Recruiting first, the newest first:
University Hospital, Toulouse · Sites in France
University Hospital, Toulouse · Sites in France
University Hospital, Toulouse · Sites in France
University Hospital, Toulouse · Sites in France
University Hospital, Toulouse · Sites in France
By country, each count listing its studies:
Of the 16 Prader-Willi Syndrome studies recruiting now, 7 (44%) set no upper age limit and 9 (56%) stop at 75 or younger; 11 take children under 18; 1 take healthy volunteers.
This study: 5 Years to 7 Years · all sexes · no healthy volunteers.
The full table on the hub →This tab as a report to print or save as PDF → With an account.
17 studies; the count open now beside each. This study's row is marked.
A study in two phases is counted once above. Listed by phase, each with its combined phases: Phase 1 2 · Phase 2 5 · Phase 3 4 · Phase 4 1
First in 2009; this study’s year is marked. 2 started in 2025.
This study's planned enrollment of 30 is close to the median of 30 across 100 interventional studies indexed under Prader-Willi Syndrome.
Median enrollment 37 across the 14 interventional studies, 300 across the 3 observational. Of the 11 that completed or were terminated, 1 (9%) have results posted.
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University Hospital, Toulouse is the lead sponsor of 807 studies on the registry; 209 are open to participants now.
None of the studies under way reaches primary completion within a year.
Among the 17 studies in Prader-Willi Syndrome by University Hospital, Toulouse, from their registry updates:
Nothing recorded among them since 2026-09-25.
This tab as a report to print or save as PDF → With an account.
Studying the cerebral activity of children with Prader-Willi Syndrom (PWS) when the study propose to them nasal activations.
The present study propose to implement fMRI and olfactory tests to describe olfactory brain activation and olfactory skills in early OT-exposed and non-exposed children with PWS.
This study is part of a wider project in collaboration with the team of S. Steculorum at the Max Planck Institute in Germany who assess the architectural and molecular characterization of the olfactory system development in a mice model of PWS and the role of early OT treatment.
Moreover, the study will take advantage of the MRI to document the long-term brain connectivity of early OT-exposed and non-exposed children.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Contraindication
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
children OT exposed have olfactory test and fMRI
Other: olfactory stimulation · Other: functional MRI
children non- OT exposed have olfactory test and fMRI
Other: olfactory stimulation · Other: functional MRI
the patients have a sniff-test
patients have a an f MRI
hyperactivation of the right amygdala in young children with PWS not early OT-exposed and aged between 5 and 7 years in response to a sweet food odor compared to a neutral non-food odor.
intensity of right amygdala in fMRI
Time frame: day 1
hyperactivation of the right amygdala in PWS children stimulated by a sweet food odor vs. a non-food odor compared to non-exposed children.
intensity of right amygdala in fMRI
Time frame: day 1
composite outcome witn an association between olfactory fMRI results and eating behavior in early OT-exposed and non-exposed children with PWS.
scores of the eating beahaviour questionnaires
Time frame: day 1
olfactory skills in early OT-exposed and non-exposed children with PWS.
scores of the sniff test between OT-exposed and non-exposed children.
Time frame: Day 1
resting brain connectivity in early OT-exposed and non-exposed children with PWS.
brain connectivity in fMRI between OT-exposed and non-exposed children.
Time frame: day 1
Plan to share: No
No publications or documents are linked to this record.
Start is estimated for Jun 2025; primary completion for Dec 2025, 6 months later.
Of 19 interventional studies with no phase under Prader-Willi Syndrome, half reached primary completion within 29 months of starting (the median), counting those still running; a quarter within 14 and three quarters within 43. This study's planned 6 months is below that.
How these figures are worked out, and which studies are left out of them.
This study is not yet recruiting, as verified in May 2025. You cannot join it, but the record below documents what was studied.
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University Hospital, Toulouse →