An observational study in All Adult Patients Undergoing an Otolaryngology Procedure With Inhaled Methoxyflurane as an Adjunct to Topical or Local Anesthesia, sponsored by Sir Mortimer B. Davis - Jewish General Hospital. Not yet recruiting. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-06-04.
Sponsored by Sir Mortimer B. Davis - Jewish General Hospital · Observational
Our objective is to explore the use of methoxyflurane anesthesia as an adjunct analgesic to local anesthesia during in-office otolaryngology procedures in a prospective pilot study. The main outcome of this study will be patient satisfaction with the medication and analgesia. Secondary outcomes will include level of sedation and analgesia, patient-reported post-procedural pain levels, and any reported adverse events.
1,092 studies on the registry are indexed under Respiratory Aspiration; 216 are open to participants now.
This study's planned enrollment of 50 is below the median of 65 across 184 observational studies indexed under Respiratory Aspiration.
Browse Respiratory Aspiration studies →Sir Mortimer B. Davis - Jewish General Hospital is the lead sponsor of 61 studies on the registry; 21 are open to participants now.
Counted across the registry records on this site, refreshed daily.
All adult patients undergoing an otolaryngology proceure in the Otolaryngology clinic of the Jewish General Hospital with inhaled methoxyflurane as an adjunct to topical or local anesthesia
All adult patients undergoing any of the following procedures with inhaled methoxyflurane as an adjunct to topical or local anesthesia:
Exclusion Criteria:
Presence of any contraindications to inhaled methoxyfluorane per product monograph:
All adult patients undergoing any of the following procedures with inhaled methoxyflurane as an adjunct to topical or local anesthesia: * Skin lesion excision or reconstruction * Fine or core needle aspiration biopsy * Mucosal biopsy * Laryngeal injection or biopsy * Myringotomy with or without tympanostomy tube insertion * Inferior turbinate reduction * Septal button insertion
Drug: Methoxyflurane anesthesia
A single Penthrox (3mL) self-inhaler will be administered 5-minutes prior to the onset of the procedure, before local anesthesia. Patients will undergo the procedure, have post-procedural vital signs, and remain in clinic for observation for 30 minutes post-procedure per our usual post-procedure monitoring.
TSQM-1.4 (Treatment Satisfaction Questionnaire for Medication 1.5)
This is a validated 14-item including Likert scales and dichotomous (yes/no) items on the effectiveness, side effects, convenience and global satisfaction with the medication taken
Time frame: At first follow-up visit (within 1 month post-procedure)
Ability to complete intended procedure
Documented by clinic nurse post- procedure
Time frame: At procedure visit
Modified Ramsay Sedation score
Maximal sedation score during procedure documented by clinic nurse
Time frame: At procedure visit
Adverse events
Either self- or physician-reported
Time frame: At procedure visit and first follow-up visit (within 1 month post-procedure)
Visual analog pain scale
Maximal degree of pain during procedure
Time frame: At procedure visit
No study locations are listed for this record.
This study is not yet recruiting, as verified in Apr 2025. You cannot join it, but the record below documents what was studied.
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Sir Mortimer B. Davis - Jewish General Hospital