An interventional study of ketamine and Erector Spinae Plane Block in Spinal Decompression, Analgesia and Erector Spinae Plane Block, sponsored by Kasr El Aini Hospital. Completed at 1 site in Egypt. Open to participants aged 20 Years and older. Per ClinicalTrials.gov, last updated 2026-03-24.
Sponsored by Kasr El Aini Hospital · Not applicable, Interventional, and Prevention
The aim of this study is to compare the quality of recovery of the erector spinae plane block (ESPB) versus ketamine-based multimodal analgesia regimen after spine decompressive surgery.
Preoperatively, standard monitors will be attached (electrocardiogram, noninvasive blood pressure, and pulse oximetry) and intravenous access will be obtained. Dexamethasone will be administered at dose of 4 mg as an antiemetic prophylaxis.
Thirty min before induction of anesthesia all patients will receive 15 mg ketorolac and 1 gm paracetamol intravenously.
General anesthesia will be induced by 1 mcg/kg fentanyl and 2 mg/kg propofol titrated till loss of verbal response. Tracheal intubation will be facilitated by 0.5 mg/kg atracurium. General anesthesia will be maintained by isoflurane (end-tidal isoflurane concentration of 1-1.2%) in air-oxygen admixture.
Fentanyl boluses of 50 mcg will be given in case of inadequate analgesia (heart rate and or systolic blood pressure increase by 20% from the baseline in absence of other causes) Intraoperative hemodynamic management will be according to the discretion of the attending anesthetist.
Postoperatively, all Patients will receive oral 1 gm of paracetamol every 6 h and 400 mg ibuprofen every 8 h.
Pain assessments using NRS (Numerical Rating Scale) at rest and during movement at 0.5 , 4, 10, 18 and 24 h postoperatively. If NRS score is > 3, intravenous 2 mg bolus of morphine will be given.
Intravenous ondansetron 4 mg will be given to treat nausea or vomiting if occurs.
At the end of 24 h postoperatively, patient's quality of recovery will be assessed using QoR-15 questionnaire and patient's satisfaction.
1,190 studies on the registry are indexed under Agnosia; 508 are open to participants now.
This study's enrollment of 62 is below the median of 78 across 1,024 interventional studies indexed under Agnosia.
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Exclusion Criteria:
Patients will be receiving ketamine bolus then continuous infusion and local wound infiltration at the end of the surgery.
Drug: ketamine · Other: Wound infiltration
Patients will be receiving erector spinae plane block
Other: Erector Spinae Plane Block
after induction of anesthesia, patients will receive ketamine bolus of 0.5 mL/kg followed by continuous infusion of 0.12 mL/k/hr until the end of surgical procedure.
after induction of anesthesia, patients will receive ultrasound guided ESPB. A total of 40 mL of 0.25% bupivacaine will be injected bilaterally at the level of transverse process opposing to the mid-point of the planned incision.
wound infiltration at the end of the surgery before the closure of fascia and subcutaneous tissues using a total of 20 ml of 0.25% bupivacaine
quality of recovery
using the QoR-15 questionnaire
Time frame: 24 hour to 25 hour after surgery
pain assessment
numerical rating scale
Time frame: 30 minutes postoperatively till 24 hours postoperatively
nalbuphine requirement
mg
Time frame: 30 minutes postoperatively till 24 hours postoperatively
time to rescue analgesia
hours
Time frame: 30 minutes postoperatively till 24 hours postoperatively
Plan to share: No — data used for statistical analysis are available from the PI upon reasonable request
No publications or documents are linked to this record.
This study is completed, as verified in Mar 2026. You cannot join it, but the record below documents what was studied.
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Kasr El Aini Hospital