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Not yet recruitingNCT06999889Updated May 31, 2025

Comparative Evaluation of Periodontal Status and Periodontal Parameters in Different Age Group Individuals With and Without Trauma From Occlusion.

An observational study in Trauma From Occlusion, sponsored by Postgraduate Institute of Dental Sciences Rohtak. Not yet recruiting at 1 site in India. Open to participants aged 26 Years to 45 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-05-31.

Sponsored by Postgraduate Institute of Dental Sciences Rohtak · Observational

Study type
Observational
Model
Case-control
Time perspective
Cross-sectional
Enrollment
208
Ages
26 Years to 45 Years
Sex
All
01

Study summary

Trauma from occlusion (TFO) is defined as an injury resulting in tissue changes within the attachment apparatus as a result of occlusal forces (Glossary of Periodontic Terms American Academy of Periodontology, 2001) This clinical condition is frequently associated with jiggling forces and results in progressive tooth mobility.Experiments performed in animals like the beagle dog showed some periodontal tissue reactions to increasing tooth mobility. Such as (i) Increase in the width of the periodontal ligament area (ii)Increase in the vascularity,vascular permeability and the migration of leukocytes from the vascular plexus and (iii) the increase in number of osteoclasts lining the marginal alveolar bone of the zone of co destruction . Also, the teeth showing increasing mobility exhibit an enhanced rate of periodontal tissue destruction when exposed to experimentally induced periodontitis When trauma from occlusion is the result of alterations in occlusal forces, it is called as primary trauma from occlusion. When it results from the reduced ability of the Periodontal tissues to resist the occlusal forces ,it is known as secondary trauma from occlusion.One of the clinical sign of TFO include presence of Fremitus which means functional tooth mobility.Aggravation of plaque- related inflammatory periodontal disease by trauma from occlusion is still under question.It is unclear whether TFO occurs primarily in periodontitis patients, or bone loss due to periodontitis leads to TFO in later stages. Review of Literature has further revealed that there is no study conducted on anterior teeth with Fremitus and its relation with periodontal parameters.So, it may be hypothesized that TFO may have impact on Periodontal tissue in different age groups as periodontitis is chronic in nature and time of initiation of the disease could not be identified.Periodontitis is chronic in nature and time of initiation of the disease could not be identified. Recently age dependent distribution of periodontitis was studied and findings reported mean clinical attachment loss increased linearly with age and recession contributed increasingly to CAL with age specially after 45-49years.Therefore reduced periodontium in later stages it may lead to TFO, as compared to early stages of life

Read the detailed description

Trauma from occlusion (TFO) is defined as an injury resulting in tissue changes within the attachment apparatus as a result of occlusal forces (Glossary of Periodontic TermsAmerican Academy of Periodontology, 2001) This clinical condition is frequently associated with jiggling forces and results in progressive tooth mobility.Experiments performed in animals like the beagle dog showed some periodontal tissue reactions to increasing tooth mobility. Such as (i) Increase in the width of the periodontal ligament area (ii)Increase in the vascularity,vascular permeability and the migration of leukocytes from the vascular plexus and (iii) the increase in number of osteoclasts lining the marginal alveolar bone of the zone of codestruction . Also, the teeth showing increasing mobility exhibit an enhanced rate of periodontal tissue destruction when exposed to experimentally induced periodontitis When trauma from occlusion is the result of alterations in occlusal forces, it is called as primary trauma from occlusion. When it results from the reduced ability of the Periodontal tissues to resist the occlusal forces ,it is known as secondary trauma from occlusion.One of the clinical sign of TFO include presence of Fremitus which means functional tooth mobility. A tooth with fremitus has excess contact, possibly related to a premature contact during habitual centric closure and excursive mandibular movements.The role of trauma from occlusion in periodontal disease relies on the belief that excessive occlusal forces do not initiate destructive chronic periodontitis .Though these forces are capable of causing periodontal injury and To establish relation between trauma from occlusion and periodontitis both should be present in destructive stages otherwise combined lesion can't be reproduced.Primary trauma from occlusion without periodontal inflammation results in no loss of attachment, with preservation of a bone matrix that is able to regenerate in the absence of traumatogenic forces. However, when periodontal inflammation is superimposed with trauma from occlusion, alterations in alveolar bone height and volume are not reverted by elimination of traumatogenic forces, with persistence of clinical mobility and gingival inflammation .Aggravation of plaque- related inflammatory periodontal disease by trauma from occlusion is still under question, and further investigations are necessary to elucidate such an association.It is unclear whether TFO occurs primarily in periodontitis patients, or bone loss due to periodontitis leads to TFO in later stages. Review of Literature has further revealed that there is no study conducted on anterior teeth with Fremitus and its relation with periodontal parameters.

So, it may be hypothesized that TFO may have impact on Periodontal tissue in different age groups as periodontitis is chronic in nature and time of initiation of the disease could not be identified. Recently age dependent distribution of periodontitis was studied and findings reported mean clinical attachment loss increased linearly with age and recession contributed increasinginly to CAL with age specially after 45-49years.Therefore reduced periodontium in later stages it may lead to TFO, as compared to early stages of life

02

Conditions studied

  • Trauma From Occlusion
03

In context

Lead sponsor

Postgraduate Institute of Dental Sciences Rohtak is the lead sponsor of 213 studies on the registry; 72 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
26 Years to 45 Years
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Probability sample

Study population

Systemically Healthy Individuals in Age Group 26-35 Yrs and 36-45Yrs.

Eligibility criteria

Inclusion Criteria:1. Systemically healthy individuals will be screened for TFO including Fremitus, Adaptability to TFO, Mobility, Pathological Migration and Tongue thrusting. 2. Systemically healthy individuals will be enrolled in to Two groups, Test group and Control group of 26-35 and 36-45 age group.

  • presence of ≥24 natural teeth

Exclusion Criteria:• Current smokers and Former smokers

  • Any systemic disease which influence the periodontal tissue such as diabetes mellitus.
  • Systemic condition such as Pregnancy and Lactation.
  • Systemic Medication for the past 6 months.
  • Patients undergoing orthodontic treatment or treated cases.
  • Any missing anterior either maxillary or Mandibular teeth.
  • History of systemic antibiotics within last 3 months
  • Periapical pathology in anterior teeth.
  • Any periodontal treatment within 6 months prior to study
  • Any developmental anomaly of anterior teeth.
  • Presence of prosthesis in Anterior teeth (Crown and Implant)
  • No vertical stops due to missing posterior teeth.
  • Patients with tongue thrusting habit.
  • Patients with parafunction like Bruxism and Clenching Identified through Interview and occlusal examination.
  • Patient with Oral Habits like Biting or Holding Objects between the Teeth.
  • Patient having any craniomandibular dysfunction or undergone any treatment for temporomandibular joint.
05

Study design

Observational model
Case-control
Time perspective
Cross-sectional
Enrollment
208 participants (estimated)
Patient registry
No

Groups and cohorts

  • Test Group-1.

    Patients showing positive fremitus test in Age Group-26-35Yrs.

    Diagnostic Test: Recording of Periodontal Parameters.

  • Test Group-2.

    Patients showing positive fremitus test in Age Group-36-45Yrs.

    Diagnostic Test: Recording of Periodontal Parameters.

  • Control Group-1

    Patients showing negative fremitus test in Age Group-26-35Yrs.

    Diagnostic Test: Recording of Periodontal Parameters.

  • Contrl Group-2

    Patients showing negative fremitus test in Age Group-36-45Yrs.

    Diagnostic Test: Recording of Periodontal Parameters.

Interventions

  • Diagnostic testRecording of Periodontal Parameters.

    Periodontal Parameters recording in terms of various indices,measurements and radiographs.

06

What researchers measure

Primary outcomes

  1. Clinical Attachment level (CAL) )

    Measured in mm from CEJ

    Time frame: average 1 year

  2. Probing Pocket Depth (PPD)

    Measured in mm from free Gingival margin.

    Time frame: average 1 year

  3. Interproximal Alveolar Bone level(From CEJ)

    Measured from CEJ

    Time frame: average 1 year

  4. Pattern of bone Loss.

    Measured from CEJ

    Time frame: average 1 year

07

Study locations

1 site
  • Department of Periodontology ,Post Graduate Institute Of Dental Sciences
    Rohtak, Haryana 124001, India
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reached

Start is estimated for Jun 2025; primary completion for Oct 2026, 16 months later.

How these figures are worked out, and which studies are left out of them.

Registered
May 15, 2025
First posted
May 31, 2025
StartEst.
Jun 2025
Primary completionEst.
Oct 2026
CompletionEst.
Dec 2026
Last update
May 31, 2025
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on May 31, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT06999889
Responsible party
Sponsor
First posted
May 31, 2025
Start date
Jun 2025 (estimated)
Primary completion
Oct 2026 (estimated)
Completion
Dec 2026 (estimated)
Last update
May 31, 2025

Study contacts

Shikha Tewari, MDS
Contact
drshikhatewari@yahoo.com
91-9416514600
Sanjay Tewari, MDS
Contact
principal.pgids@uhsr.ac.in
01262-297876
Ashish Kumar, BDS
principal investigator · Post Graduate Institute of Dental Sciences ,Rohtak

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is not yet recruiting, as verified in May 2025. You cannot join it, but the record below documents what was studied.

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