An interventional study of glycine subgingival sandblasting group and erythritol subgingival sandblasting group and control group in Peri-implantitis, Dental Implant Complications and Periodontal Inflammation, sponsored by Hui Xie. Completed at 1 site in China. Per ClinicalTrials.gov, last updated 2025-05-31.
Sponsored by Hui Xie · Not applicable, Interventional, and Other
Abstract Objective The purpose of this study was to analyze the factors affecting the occurrence of peri-implant inflammation in patients with oral implant repair, and to explore the effect of subgingival sandblasting technology on the maintenance of microecology around the implant, so as to provide a basis for optimizing clinical prevention and treatment strategies.
Method Ninety-six patients with early periimplantitis treated in our hospital from July 2022 to July 2024 were selected as the inflammation group. All patients were randomly divided into control group, glycine subgingival sandblasting group and erythritol subgingival sandblasting group (n=32). The clinical therapeutic effect of the two groups was compared. A total of 102 patients who underwent oral implant repair in our hospital during the same period without peri-implant inflammation were selected as the group without inflammation. The independent risk factors of peri-implant inflammation were analyzed.
313 studies on the registry are indexed under Peri-Implantitis; 85 are open to participants now.
This study's enrollment of 96 is above the median of 40 across 191 interventional studies indexed under Peri-Implantitis.
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Inclusion Criteria Clinical diagnosis of peri-implantitis (PD ≥4 mm with BOP/suppuration)
At least one functional dental implant in place for ≥6 months
Willing and able to maintain standard oral hygiene protocol
No antibiotic or anti-inflammatory drug use in the past 30 days
Absence of uncontrolled systemic diseases (e.g., diabetes, hypertension)
Complete baseline clinical data available (medical history, radiographs, lab results)
Exclusion Criteria Acute oral infections requiring immediate treatment
History of radiation therapy to the head/neck region
Severe uncontrolled periodontal disease
Active malignancy or current cancer treatment
Coagulation disorders or anticoagulant therapy
Pregnancy or lactation
Cognitive impairment affecting compliance
Allergy to glycine or erythritol compounds
Non-Inflammatory Group Additional Criteria Successful implant placement with no signs of inflammation (PD ≤3 mm, no BOP)
Matched to study group by age (±5 years) and implant location
Meets all other inclusion/exclusion criteria regarding systemic health
Note: All participants must provide informed consent. Healthy volunteers without implants are not eligible.
The control group was given ultrasonic subgingival curettage. With Swiss EMS ultrasonic therapy instrument, both the operator and the patient should wear safety goggles before operation. After the operator guides the patient to gargle, the mouth opener should be placed to perform ultrasonic subgingival curetting. The debridement time of the implant area should be controlled within 6 minutes, and the debridement time of other sites should be 5 s.
Other: control group
Given glycine subgingival sandblasting group glycine subgingival sandblasting group. Swiss EMS ultrasonic therapy instrument and EMS glycine sandblasting were used. Before the operation, both parties should wear safety glasses and place the mouth opener after the patient gargled. The location of sandblasting was selected to be 1-2 mm below the gingiva. During the operation, the time of sandblasting in the planting area should be controlled within 10 minutes, and then the time of sandblasting at other sites with the same amount of water and power should be controlled within 5s. After sandblasting, the patient's mouth was continuously rinsed with normal saline for 20s. After the operation, the patient was informed of the precautions after the operation, and the patient was instructed to master the correct oral maintenance method, pay attention to maintaining the cleanliness around the implant, and adhere to regular periodontal maintenance.
Other: glycine subgingival sandblasting group and erythritol subgingival sandblasting group
Given glycine subgingival sandblasting group glycine subgingival sandblasting group. Swiss EMS ultrasonic therapy instrument and EMS glycine sandblasting were used. Before the operation, both parties should wear safety glasses and place the mouth opener after the patient gargled. The location of sandblasting was selected to be 1-2 mm below the gingiva. During the operation, the time of sandblasting in the planting area should be controlled within 10 minutes, and then the time of sandblasting at other sites with the same amount of water and power should be controlled within 5s. After sandblasting, the patient's mouth was continuously rinsed with normal saline for 20s. After the operation, the patient was informed of the precautions after the operation, and the patient was instructed to master the correct oral maintenance method, pay attention to maintaining the cleanliness around the implant, and adhere to regular periodontal maintenance.
The control group was given ultrasonic subgingival curettage. With Swiss EMS ultrasonic therapy instrument, both the operator and the patient should wear safety goggles before operation. After the operator guides the patient to gargle, the mouth opener should be placed to perform ultrasonic subgingival curetting. The debridement time of the implant area should be controlled within 6 minutes, and the debridement time of other sites should be 5 s.
Change in Plaque Index (PLI) Score
Change in Plaque Index (PLI; scored 0-3) from baseline to 3 and 6 months post-treatment, comparing subgingival sandblasting (glycine/erythritol) versus standard ultrasonic curettage. Higher scores indicate greater plaque accumulation.
Time frame: Baseline, 3 months, 6 months.
Change in Bleeding Index (BI) Score
Change in Bleeding Index (BI; scored 0-3) from baseline to 3 and 6 months post-treatment, comparing interventions. Higher scores indicate more severe gingival bleeding.
Time frame: Baseline, 3 months, 6 months.
Change in Probing Depth (PD)
Change in Probing Depth (PD; measured in millimeters) from baseline to 3 and 6 months post-treatment, comparing interventions. Deeper pockets indicate worse peri-implant inflammation.
Time frame: Baseline, 3 months, 6 months.
Inflammatory Biomarker Levels (IL-6, IL-1β)
Change in pro-inflammatory cytokine levels measured in peri-implant crevicular fluid via ELISA across treatment groups.
Time frame: Baseline, 1 month post-treatment, 3 months post-treatment, 6 months post-treatment
Peri-Implantitis Recurrence Rate
Incidence of peri-implant inflammation recurrence (PD ≥5mm with bleeding/suppuration) in treated patients.
Time frame: 12 months post-treatment
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