An interventional study of underwater endoscopic mucosal resection and Hot snare polypectomy in Pedunculated Colorectal Polyp, sponsored by Fudan University. Not yet recruiting at 1 site in China. Open to participants aged 35 Years to 80 Years. Per ClinicalTrials.gov, last updated 2025-05-30.
Sponsored by Fudan University · Not applicable, Interventional, and Treatment
A prospective, single-center, open-label, randomized controlled study to compare the effectiveness and safety of underwater endoscopic mucosal resection (UEMR) and hot snare polypectomy (HSP) in treating Pedunculated colorectal polyps less than 10mm in size.
312 studies on the registry are indexed under Polyps; 60 are open to participants now.
This study's planned enrollment of 338 is above the median of 150 across 204 interventional studies indexed under Polyps.
Browse Polyps studies →Fudan University is the lead sponsor of 1,315 studies on the registry; 643 are open to participants now.
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Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Malignancy means cancer. Criteria about another or earlier malignancy ask whether you have had a different cancer, usually within a set number of years.
Some are commonly allowed, such as treated skin cancers other than melanoma and early cancers removed completely — check the exceptions this study lists.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Cancer (malignancy)
Malignancy means cancer. Criteria about another or earlier malignancy ask whether you have had a different cancer, usually within a set number of years.
Some are commonly allowed, such as treated skin cancers other than melanoma and early cancers removed completely — check the exceptions this study lists.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
The UEMR procedure included the following: (1) Water infusion to distend the intestinal lumen; (2) entrapment of the mucosal protrusion with a snare; and (3) resection using electrocautery
Procedure: underwater endoscopic mucosal resection
The HSP procedure included the following: (1) entrapment and resection of the polyp with a snare with electrocautery.
Procedure: Hot snare polypectomy
The Pedunculated colorectal polyps less than 10mm in size in this group will be treated by UEMR
The Pedunculated colorectal polyps less than 10mm in size in this group will be treated by HSP
Post-polypectomy Bleeding
Presence of Clinically Significant Immediate Post-polypectomy Bleeding（CSIPB） or Clinically Significant Delayed Post-polypectomy Bleeding (CSDPB). CSIPB was defined as any bleeding not responding to water jet irrigation or STSC and therefore requiring either coagu lation forceps or mechanical clips to achieve hemostasis. CSDPB was defined as any bleeding after completion of the procedure requiring emergency room presentation, hospital isation or re-intervention (endoscopy, angiography, surgery).
Time frame: 2 weeks after the procedure
postoperative electrocoagulation syndrome
Postoperative electrocoagulation syndrome （PEECS）defined as localized abdominal tenderness plus at least one of the following: (1) body temperature \> 37.6 °C; (2) white-blood-cell count \> 10 × 10⁹ /L; or (3) C-reactive protein \> 0.5 mg/dL, after ruling out delayed postoperative perforation).
Time frame: 2 weeks after the procedure
en bloc resection
Rate of en bloc resection rate
Time frame: immediately after the procedure
R0 resection
Rate of R0 resection
Time frame: 2 weeks after the procedure
Delayed perforation
Rate of delayed perforation
Time frame: 2 weeks after the procedure
Plan to share: Yes — All collected IPD
Supporting information: Study protocol, Statistical analysis plan, Informed consent form
Time frame: 1 year after completion of this study
Access criteria: All researchers can require the original data from principal investigator of this study (Email address: 18817870866@163.com)
No publications or documents are linked to this record.
This study is not yet recruiting, as verified in May 2025. You cannot join it, but the record below documents what was studied.
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