A Phase 2 interventional study of Febuxostat Tablets and Metformin in Gout, sponsored by Mostafa Bahaa. Completed at 1 site in Egypt. Open to participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2026-09-17.
Sponsored by Mostafa Bahaa · Phase 2, Interventional, and Treatment
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Gout is a systemic disease that results from the deposition of monosodium urate crystals (MSU) in tissues. Increased serum uric acid (SUA) above a specific threshold (>6.8 mg/dl) is a requirement for the formation of uric acid crystals. MSU crystals can be deposited in all tissues mainly in and around the joints forming tophi. Early presentation of gout is an acute joint inflammation that is quickly relieved by non-steroidal anti-inflammatory drugs (NSAIDs) or colchicine. Lowering SUA levels below deposition threshold either by dietary modification or using serum uric acid lowering drugs is the main goal in management of gout. This results in dissolution of MSU crystals preventing further attacks
345 studies on the registry are indexed under Gout; 49 are open to participants now.
This study's enrollment of 60 is below the median of 83 across 286 interventional studies indexed under Gout.
Browse Gout studies →Mostafa Bahaa is the lead sponsor of 18 studies on the registry; 5 are open to participants now.
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Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
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BMI (body mass index)
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
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Immunosuppression
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patients will receive febuxostat 80 mg daily for 6 months.
Drug: Febuxostat Tablets
patients will receive metformin 1000 mg daily for 6 months
Drug: Febuxostat Tablets · Drug: Metformin
Febuxostat is a selective xanthine oxidase inhibitor (XOI) that targets uric acid generation. It has been used as a SUA lowering agent in patients not responding to allopurinol
Metformin is an oral antihyperglycemic drug widely used in type 2 diabetes (T2DM) treatment. Most of its effects are exerted via an indirect induction of the phosphorylated activation of AMP-activated protein kinase (AMPK)
Change in serum uric acid level
Serum uric acid is the major metabolite of purine pathway and used in diagnosis of gouty patients
Time frame: 3 months
Ran from May 2025 to primary completion in Dec 2025, 7 months.
Of 30 phase 2 interventional studies under Gout, half reached primary completion within 14 months of starting (the median), counting those still running; a quarter within 7 and three quarters within 22. This study's 7 months is below that.
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This study is completed, as verified in Sep 2026. You cannot join it, but the record below documents what was studied.
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Studies of the drug tested here: Metformin
Mostafa Bahaa