An interventional study of Precision TMS with SFA and Control TMS with SFA in Aphasia, Stroke and Language, sponsored by Medical College of Wisconsin. Recruiting at 1 site in United States. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-07-10.
Sponsored by Medical College of Wisconsin · Not applicable, Interventional, and Treatment
The investigator proposes to examine the effects of excitatory transcranial magnetic stimulation (TMS) combined with semantic feature analysis (SFA) language therapy to improve word-finding abilities in stroke survivors with aphasia (SWA).
In this project, the investigator will use functional neuroimaging and inhibitory TMS to determine precise therapy-responsive targets for excitatory TMS therapy with SFA. One group of stroke survivors will receive SFA + TMS targeting the precision site, and another group will receive SFA + TMS targeting a control site. The primary outcome will be changes in picture naming accuracy. We expect that excitatory TMS targeting a precision site would result in larger improvements in naming accuracy than TMS targeting a control site. Results will provide the efficacy of precision TMS in post-stroke aphasia.
338 studies on the registry are indexed under Aphasia; 95 are open to participants now.
This study's planned enrollment of 50 is above the median of 30 across 298 interventional studies indexed under Aphasia.
Browse Aphasia studies →Medical College of Wisconsin is the lead sponsor of 548 studies on the registry; 122 are open to participants now.
Of its 75 completed or terminated interventional studies of FDA-regulated products, 57 (76%) have results posted.
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Exclusion Criteria:
SFA will be administered immediately after precision TMS
Device: Precision TMS with SFA
SFA will be administered immediately after control TMS
Device: Control TMS with SFA
Excitatory TMS delivered using a precision site finding approach and intermittent theta burst stimulation protocol
Excitatory TMS using intermittent theta burst stimulation delivered to a control vertex site.
Accuracy on a picture naming test
Changes in accuracy on untrained stimuli after SFA+TMS compared between groups (precision, control).
Time frame: immediately after and 8-12 weeks after last SFA+TMS treatment
Plan to share: No
Started Sep 2025 (actual). Primary completion is estimated for Dec 2036, 135 months after the start.
Of 183 non-industry interventional studies with no phase under Aphasia, half reached primary completion within 36 months of starting (the median), counting those still running; a quarter within 19 and three quarters within 57. This study's planned 135 months is above that.
Counting every sponsor, half of 185 studies reached it within 36 months; a quarter within 20 and three quarters within 57.
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Medical College of Wisconsin →