An interventional study of cerebral blood flow measurment and TTE CO measurment in Non Cardiac Surgery, sponsored by Ain Shams University. Completed at 1 site in Egypt. Open to participants aged 18 Years to 55 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-03-12.
Sponsored by Ain Shams University · Not applicable, Interventional, and Diagnostic
Cardiac output (CO) is challenging to measure at the bedside. The traditional gold standard for measuring CO requires the insertion of a pulmonary artery catheter which is invasive, associated with a risk for serious complications [3],with no clinical benefits.
The cerebral blood flow (CBF) is considered to be a proportion of total cardiac output (CO). It has been stated earlier that approximately 15% of resting CO is distributed to the brain. Therefore, the flow through the CCA might serve as a surrogate parameter for CO.
Study Procedures:
After the patients consented and after the induction of the anesthesia, a transthoracic echocardiography will be done to measure the cardiac output, where the LVOT diameter is measured from the parasternal long axis view to calculate the radius of the LVOT, and the velocity time integral (VTI) is calculated from the apical five chamber and the apical three chamber view, and by applying the equation the cardiac output will be calculated CO= π* (LVOT radius)2* (LVOT VTI) *HR The patients will be monitored using electrocardiography, non-invasive blood pressure measurement and pulse oximetry (SpO2), general anesthesia will be induced using Propofol 2mg/Kg, Rocuronium 0.5mg/Kg and fentanyl 1ug/kg and the all the patients will be intubated with an endotracheal tube size 7 for female and 8 for males A warming blanket will be ensured to all the patients to maintain the core temperature at 36ْC For all the patients involved in the study. The patients' Cardiac output as measured before will be correlated with the carotid blood flow after scanning the carotid artery to exclude a significant lesion as measured by the following equation and the average of a three consecutive reading will be recorded, these will be repeated every 30 min. for the procedures.
π* (Carotid diameter )4/4* VTI *HR The carotid blood flow will be measured by applying a linear probe along the medial aspect of the sternocleidomastoid muscle above the common carotid artery, by applying pulsed wave, the pulse of the carotid artery will be traced and the VTI automatically calculated the machine. The patients EtCO2 will be recorded and the average of the reading over a time interval of 30 minutes will be recorded and correlated to the cardiac output as measured by both the carotid blood flow and the TTE .The blood pressure, heart rate will be monitored and recorded
Ain Shams University is the lead sponsor of 1,876 studies on the registry; 423 are open to participants now.
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Exclusion Criteria:
The patients EtCO2 will be recorded and the average of the reading over a time interval of 30 minutes will be recorded and correlated to the cardiac output as measured by both the carotid blood flow and the TTE
Diagnostic Test: ETCO2
a transthoracic echocardiography will be done to measure the cardiac output
Diagnostic Test: TTE CO measurment
The patients' Cardiac output as measured before will be correlated with the carotid blood flow after scanning the carotid artery to exclude a significant lesion as measured by the following equation and the average of a three consecutive reading will be recorded
Diagnostic Test: cerebral blood flow measurment
measuring CO using cerebral blood flow
measuring CO using TTE
measure the average ETCO2 over 30 minutes period
correlation of ETCO2
we assume that the change in the gradient of carbon dioxide release over a time in mechanically ventilated patients may be directly proportionate to the cardiac output and could reflect it. In the current study we will correlate the aforementioned hypothesis with the change in the cardiac output compared to the change in the carotid blood flow as revealed by the change in the cardiac output as measured by the transthoracic echocardiography.
Time frame: during operation
This study is completed, as verified in Apr 2025. You cannot join it, but the record below documents what was studied.
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Ain Shams University