An observational study in Maternal Obesity and Hypoxia Neonatal, sponsored by Ain Shams University. Not yet recruiting. Open to female participants aged 18 Years to 40 Years. Per ClinicalTrials.gov, last updated 2025-04-09.
Sponsored by Ain Shams University · Observational
Offspring from overweight or obese mothers appear to be at up to 38% increased risk of being admitted to the neonatal intensive care unit than the offspring of mothers with a normal BMI. In terms of Apgar scores at birth, babies of obese mothers have been reported to have a 31% excess risk of having a low Apgar score (defined at \<7 at 1 minute) . Infants born to obese mothers demonstrate a spectrum of outcomes, suggesting that there is a complex interplay of factors that defines the precise altered metabolic environment to which the fetus is exposed and that determines the risk of complications
The investigators need to improve understanding of the specific molecular factors that contribute either individually or synergistically to detrimental fetal outcomes. Moreover, The investigators need to identify the essential maternal markers that need to be tightly regulated during pregnancy to improve outcomes. Here in, The investigators discuss the influence of maternal obesity and factors associated with the obesogenic intrauterine environment on fetal lung development and respiratory outcomes in offspring at birth importantly, The investigators identify a series of molecular changes encountered during pregnancy that may program the observed respiratory outcomes in clinical practice. The effects of maternal obesity on severe neonatal asphyxia may be partly explained by traumatic labor, which often results from macrosomia. Another consequence of maternal obesity is fetal hyperinsulinemia, which may be related to chronic hypoxia even without diabetes . Other mechanisms that explain the effect of maternal obesity on neonatal asphyxia include lipotoxicity, placental inflammation and vasculopathy, and cord coiling. Evidence has demonstrated altered gene expression in full-term newborns of mothers with obesity, involving dysregulation of brain development, inflammatory and immune signaling, glucose and lipid homeostasis, and oxidative stress
18 - 40 years pregnant females 37 weeks or more
Exclusion Criteria:
women with body mass index equal to 25 kg/m2 or more at time of delivery.
Other: compare infant hypoxic events in both groups
women with body mass index (18.5-24.9 kg/m2) at time of delivery
Other: compare infant hypoxic events in both groups
early neonatal resuscitation will be done by the pediatrician according to the guidelines, APGAR score of the baby will be calculated,, any hypoxic events will be traced and any need of respiratory support for the baby or NICU admission, as well as weight of the baby, mode of delivery and any birth traumas will be recorded.all this will be compared between two groups.
Rate of admission to neonatal observation room
Time frame: 6 hours post delivery
Rate of cesarean-sections.
Time frame: 12 hours
Oxygen saturation at birth.
Time frame: 2 hours post delivery
Number of babies with NICU Admission.
Time frame: 6 hours post delivery
Number of babies with birth trauma.
Time frame: 2 hours post delivery
Number of babies with meconium aspiration.
Time frame: 2 hours post delivery
No study locations are listed for this record.
This study is not yet recruiting, as verified in Feb 2025. You cannot join it, but the record below documents what was studied.
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Ain Shams University