ClinicalTrials.gg
Sign In
RecruitingNCT06917222Updated Sep 25, 2025

Slide Tracheoplasty Versus Tracheal Resection Anastomosis in Acquired Tracheal Stenosis

An interventional study of Slide tracheoplasty and Tracheal resection anastomosis in Tracheal Stenosis and Subglottic Stenosis, sponsored by Mansoura University Hospital. Recruiting at 1 site in Egypt. Per ClinicalTrials.gov, last updated 2025-09-25.

Sponsored by Mansoura University Hospital · Not applicable, Interventional, and Treatment

From the registry’s dates

  • Primary completion was expected by Jun 2026, 5 months ago, but the record still lists the study as recruiting.
  • Started May 2025; still recruiting 1 year 6 months later.
Phase
Not applicable
Study type
Interventional
Enrollment
30
Allocation
Randomized
Sex
All
01

Study summary

Aim of the Work To compare the clinical outcomes between patients will undergo slide tracheoplasty and those will undergo tracheal resection anastomosis for acquired tracheal stenosis.

02

Conditions studied

  • Tracheal Stenosis
  • Subglottic Stenosis

Browse trials for

Keywords

  • Slide tracheoplasty
  • Tracheal resection anastomosis
03

In context

Tracheal Stenosis

42 studies on the registry are indexed under Tracheal Stenosis; 11 are open to participants now.

This study's planned enrollment of 30 is above the median of 22 across 24 interventional studies indexed under Tracheal Stenosis.

Browse Tracheal Stenosis studies →

Lead sponsor

Mansoura University Hospital is the lead sponsor of 50 studies on the registry; 7 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
Child (0–17), Adult (18–64), Older adult (65+)
Sexes eligible
All
Accepts healthy volunteers
No

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • All patients with grade III, IV acquired tracheal stenosis (e.g., due to trauma, prolonged intubation) regardless their age or sex.

    • Patient with symptomatic high grade II acquired laryngotracheal stenosis after failure of endoscopic interventions.
    • Clinical indications for surgical intervention (Symptoms of airway obstruction).
    • Feasible for surgical intervention.

Exclusion criteria

Exclusion Criteria:

  • congenital tracheal stenosis

    • Malignant stenosis.
    • Severe comorbidities that contraindicate the surgery.
    • Patients refusing to sign the consent.
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Single (Outcomes assessor)
Enrollment
30 participants (estimated)

Study arms

  • Experimental
    Slide tracheoplasty

    Procedure: Slide tracheoplasty

  • Experimental
    Tracheal resection anastomosis

    Procedure: Tracheal resection anastomosis

Interventions

  • ProcedureSlide tracheoplasty

    Management of tracheal stenosis by slide tracheoplasty

  • ProcedureTracheal resection anastomosis

    Management of tracheal stenosis by tracheal resection anastomosis

06

What researchers measure

Primary outcomes

  1. Success Rate of Procedure

    Defined as the absence of stridor or the need for re-intervention within a defined follow-up period (3 months

    Time frame: 3-6 months

Secondary outcomes

  1. Complication Rates

    Evaluation of perioperative complications: * Immediate Complications: Airway obstruction, pneumothorax, anastomotic leak, or accidental injury to surrounding structures (e.g., RLN). * Delayed Complications: Stenosis, granulation tissue formation, tracheomalacia, or infection (e.g., mediastinitis). * Mortality Rate: Intraoperative and 30-day mortality rates

    Time frame: 3 months

  2. Duration of Hospital Stay

    Measured from the day of surgery to discharge

    Time frame: 3 months

  3. Time to Decannulation

    Time taken for patients to be successfully decannulated, which can be indicative of recovery and airway stability.

    Time frame: 3 months

07

Study locations

1 of 1 sites recruiting
  • Eslam Hamed
    Al Mansurah, Egypt
    Recruiting
08

References and documents

Publications

  • Manning PB, Rutter MJ, Lisec A, Gupta R, Marino BS. One slide fits all: the versatility of slide tracheoplasty with cardiopulmonary bypass support for airway reconstruction in children. J Thorac Cardiovasc Surg. 2011 Jan;141(1):155-61. doi: 10.1016/j.jtcvs.2010.08.060. Epub 2010 Nov 5. PubMed 21055774 ↗
  • Schweiger C, Cohen AP, Rutter MJ. Tracheal and bronchial stenoses and other obstructive conditions. J Thorac Dis. 2016 Nov;8(11):3369-3378. doi: 10.21037/jtd.2016.11.74. PubMed 28066618 ↗
  • Smith MM, Cotton RT. Diagnosis and management of laryngotracheal stenosis. Expert Rev Respir Med. 2018 Aug;12(8):709-717. doi: 10.1080/17476348.2018.1495564. Epub 2018 Jul 12. PubMed 29969925 ↗
  • Tsang V, Murday A, Gillbe C, Goldstraw P. Slide tracheoplasty for congenital funnel-shaped tracheal stenosis. Ann Thorac Surg. 1989 Nov;48(5):632-5. doi: 10.1016/0003-4975(89)90777-7. PubMed 2818051 ↗
  • Zalzal HG, Behzadpour HK, Leonard J, Sinha P, Preciado DA. Systematic Review of Slide Tracheoplasty Outcomes. Ann Otol Rhinol Laryngol. 2023 May;132(5):558-565. doi: 10.1177/00034894221104955. Epub 2022 Jun 20. PubMed 35723210 ↗
  • Bocage JP, Caccavale R, Lewis R, Sisler G, MacKenzie J. Tracheal stenosis. N J Med. 1990 Aug;87(8):631-4. PubMed 2395535 ↗
  • de Alarcon A, Rutter MJ. Cervical slide tracheoplasty. Arch Otolaryngol Head Neck Surg. 2012 Sep;138(9):812-6. doi: 10.1001/archoto.2012.1768. PubMed 22986713 ↗
  • Freitag L, Darwiche K. Endoscopic treatment of tracheal stenosis. Thorac Surg Clin. 2014 Feb;24(1):27-40. doi: 10.1016/j.thorsurg.2013.10.003. PubMed 24295657 ↗
  • Grillo HC. Surgical treatment of postintubation tracheal injuries. J Thorac Cardiovasc Surg. 1979 Dec;78(6):860-75. PubMed 502569 ↗
  • Li C, Rutter MJ. Acquired tracheal stenosis: Cervical slide tracheoplasty. Semin Pediatr Surg. 2021 Jun;30(3):151058. doi: 10.1016/j.sempedsurg.2021.151058. Epub 2021 May 25. PubMed 34172213 ↗
  • Abdou EH, Elkahwagi M, Elsobki AA, Elshaer M. Slide tracheoplasty versus tracheal resection anastomosis for acquired laryngotracheal stenosis: a prospective randomized controlled trial. Eur Arch Otorhinolaryngol. 2026 May 21. doi: 10.1007/s00405-026-10296-8. Online ahead of print. PubMed 42165884 ↗

Individual participant data

Plan to share: Undecided

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Sep 25, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT06917222
Lead sponsor
Mansoura University Hospital
Responsible party
Eslam Hamed Elsayed Abdou (Assistant lecturer, Mansoura University Hospital) — Principal investigator
First posted
Apr 8, 2025
Start date
May 1, 2025
Primary completion
Jun 1, 2026 (estimated)
Completion
Aug 1, 2026 (estimated)
Last update
Sep 25, 2025

Study contacts

Eslam Hamed Abdou, Assistant lecturer
Contact
eslamhamed@mans.edu.eg
+201015566532
Ahmed Elsobki, Associated professor
Contact
Ahmedelsobkyorl@gmail.com
+20 122 7505929

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Interested in this study?

Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.

Contact study team

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Other studies in this condition

Tracheal Stenosis →

Other studies from this sponsor

Mansoura University Hospital

Start the discussion