Effect of a Novel Blend of Plant Protein and Additional Ingredients on Resistance Training Adaptations

Lead sponsor

Lindenwood University is the lead sponsor of 29 studies on the registry; 6 are open to participants now.

Study arms

• Experimental
  Novel Plant Protein

  Novel plant protein blend containing 30 grams of protein taken twice per day for 8 weeks

  Dietary Supplement: Novel Plant Protein Blend

• Active comparator
  Pea/Rice Protein

  Pea/Rice protein blend containing 30 grams of protein taken twice per day for 8 weeks

  Dietary Supplement: Pea/Rice Protein Blend

• Active comparator
  Whey Protein

  Whey protein blend containing 30 grams of protein taken twice per day for 8 weeks

  Dietary Supplement: Whey Protein

• Placebo comparator
  Carbohydrate Placebo

  Carbohydrate placebo (maltodextrin) taken twice per day for 8 weeks

  Dietary Supplement: Carbohydrate Placebo

Interventions

• Dietary supplementNovel Plant Protein Blend

  Novel plant protein blend containing 30 grams of protein.

• Dietary supplementPea/Rice Protein Blend

  Pea/Rice protein blend containing 30 grams of protein

• Dietary supplementWhey Protein

  Whey concentrate protein blend containing 30 grams of protein

• Dietary supplementCarbohydrate Placebo

  Maltodextrin placebo

Primary outcomes

1. Change in 4-Compartment Lean Mass

   Lean mass will be assessed using a 4-compartment model, which includes measurements of body density, total body water, and bone mineral content.

   Time frame: Week 0, Week 4, and Week 8

2. Change in Perceptual Indicators of Training State

   Participants will rate their readiness to train, soreness, recovery, energy, and sleep quality using 100-mm visual analog scales. Each scale is anchored with contextually appropriate statements such as "Lowest Possible" and "Highest Possible."

   Time frame: Week 0, Week 4, and Week 8

3. Change in Profile of Mood States (POMS) Score

   Mood state will be assessed using the Profile of Mood States (POMS) questionnaire, a validated tool for measuring transient affective states. The POMS consists of six subscales (Tension-Anxiety, Depression-Dejection, Anger-Hostility, Vigor-Activity, Fatigue-Inertia, and Confusion-Bewilderment), with a Total Mood Disturbance (TMD) score calculated by summing negative subscale scores and subtracting the Vigor score. Higher TMD scores indicate greater mood disturbance, while lower scores indicate improved mood state.

   Time frame: Week 0, Week 4, and Week 8

4. Change in Pressure to Pain Threshold

   Pressure pain threshold will be assessed using a digital algometer to determine the minimum pressure required to elicit pain. Higher scores indicate higher tolerance to pain.

   Time frame: Week 0, Week 4, and Week 8

5. Change in Handgrip Strength

   Maximal handgrip strength will be assessed using a calibrated hand dynamometer. Higher values indicate greater strength.

   Time frame: Week 0, Week 4, and Week 8

6. Change in Isometric Mid-Thigh Pull Force

   Maximal force output will be assessed using an isometric mid-thigh pull on a force plate, measured in Newtons. Higher scores equal greater force production

   Time frame: Week 0, Week 4, and Week 8

7. Change in Hex Bar Deadlift One-Repetition Maximum (1RM)

   Maximal hex bar deadlift strength will be assessed using a standardized one-repetition maximum (1RM) test.

   Time frame: Week 0, Week 4, and Week 8

8. Change in Bench Press One-Repetition Maximum (1RM

   Maximal upper-body strength will be assessed using a standardized one-repetition maximum (1RM) bench press test.

   Time frame: Week 0, Week 4, and Week 8

9. Change in Isokinetic Peak Knee Extension Torque

   Peak torque of the quadriceps will be assessed using an isokinetic dynamometer. Higher values indicate greater knee extensor strength.

   Time frame: Week 0, Week 4, and Week 8

10. Performance in 5 Sets of Hex Bar Deadlift Protocol

    Strength endurance will be assessed using a hex bar deadlift protocol consisting of 3 sets of 10 repetitions at 70% 1RM and 2 sets to failure at 80% 1RM. Repetition count and total volume lifted will be recorded.

    Time frame: Week 0, Week 4, and Week 8

Secondary outcomes

1. Change in 4-Compartment Fat Mass

   Fat mass will be measured using a 4-compartment model, which integrates body density, total body water, and bone mineral content.

   Time frame: Week 0, Week 4, and Week 8

2. Change in 4-Compartment Fat-Free Mass

   Fat-free mass will be assessed using a 4-compartment model, providing a more precise measurement of body composition changes.

   Time frame: Week 0, Week 4, and Week 8

3. Change in 4-Compartment Percent Body Fat

   Body fat percentage will be assessed using a 4-compartment model.

   Time frame: Week 0, Week 4, and Week 8

4. Change in Total, Extracellular, and Intracellular Body Water

   Hydration status will be measured using bioelectrical impedance analysis (BIA) to assess total, extracellular, and intracellular body water content.

   Time frame: Week 0, Week 4, and Week 8

5. Change in Dry Fat-Free Mass

   Dry fat-free mass will be assessed using a combination of dual-energy X-ray absorptiometry (DEXA) and bioelectrical impedance analysis (BIA) for a comprehensive measure of lean tissue mass.

   Time frame: Week 0, Week 4, and Week 8

Individual participant data

Plan to share: No — IPD will not be shared