CClinicalTrials.gg
Enrolling by invitationNCT06883838CASCADEUpdated Jul 24, 2026

Project CASCADE: Community and Academic Synergy for Cancer Survivorship Care Delivery Enhancement

An interventional study of Survivorship care delivery intervention in Cancer Survivorship, sponsored by The University of Texas Health Science Center, Houston. Enrolling by invitation at 1 site in United States. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-07-24.

Sponsored by The University of Texas Health Science Center, Houston · Not applicable, Interventional, and Health services research

Phase
Not applicable
Study type
Interventional
Enrollment
5,584
Allocation
Randomized
Ages
18 Years and older
Sex
All
01

Study summary

The purpose of this study is to implement a clinic-level cancer survivorship care delivery intervention in partnership with community health center clinicians, patients, and community representatives to test effectiveness of the intervention to improve patient and clinician outcomes and to evaluate implementation of the intervention using an iterative, concurrent mixed-methods approach guided by the Practice Change Model.

02

Conditions studied

  • Cancer Survivorship

Keywords

  • cancer survivorship
  • community health centers
  • care delivery
  • primary care
03

In context

Lead sponsor

The University of Texas Health Science Center, Houston is the lead sponsor of 880 studies on the registry; 209 are open to participants now.

Of its 170 completed or terminated interventional studies of FDA-regulated products, 140 (82%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Eligibility criteria

Inclusion Criteria (participants):

-at least one visit to the Community Health Centers (CHCs) in the prior year

Exclusion Criteria (participants):

- no history of cancer recorded in the problem list or past medical history in the medical record

Inclusion Criteria (clinicians):

-employed clinicians (e.g. physicians, nurses, pharmacists, or other allied health professionals) and non-clinician staff of the participating CHC clinics

05

Study design

Phase
Not applicable
Primary purpose
Health services research
Allocation
Randomized
Intervention model
Crossover assignment
Masking
None (open label)
Enrollment
5,584 participants (estimated)

Study arms

  • Experimental
    Step 1 (2 clinics)-6 months control then 12 months intervention

    Behavioral: Survivorship care delivery intervention

  • Experimental
    Step 2 (2 clinics)-12 months control then 12 months intervention

    Behavioral: Survivorship care delivery intervention

  • Experimental
    Step 3 (2 clinics)-18 months control then 12 months intervention

    Behavioral: Survivorship care delivery intervention

  • Experimental
    Step 4 (2 clinics)- 24 months control then 12 months intervention

    Behavioral: Survivorship care delivery intervention

Interventions

  • BehavioralSurvivorship care delivery intervention

    Guided by the Practical, Robust Implementation and Sustainability Model (PRISM), the intervention includes three evidence-based components: 1. Training: This will include provider-to-provider tele-mentoring using Enhancing Community Health Outcomes (ECHO). 2. Tracking: This includes systematically assessing cancer history and monitoring survivors' care to plan and organize subsequent care. 3. Coordinating care for cancer survivors. Each clinic leader will designate a staff member (or members) as the care coordinator champion after exploring current clinic staff, skills, and capacity of various staff roles.

06

What researchers measure

Primary outcomes

  1. Proportion of eligible cancer survivors screened for second primary cancers

    Data derived from electronic health records

    Time frame: every 6 months from baseline to end of study (about 36 months from baseline)

Secondary outcomes

  1. Change in proportion of primary care clinician knowledge of cancer survivorship care

    Assessed by self-administered survey

    Time frame: baseline, six months following end of intervention period

  2. Change proportion of survivors that report better experience of provider communication as assessed by the adapted Consumer Assessment of Healthcare Providers and Systems (CAHPS 4.0)

    Time frame: baseline, six months following end of intervention period

  3. Change proportion of survivors that report better experience of care coordination as assessed by the adapted Consumer Assessment of Healthcare Providers and Systems (CAHPS 4.0)

    Time frame: baseline, six months following end of intervention period

  4. Proportion of survivors who received guideline-recommended surveillance for the most prevalent cancers (breast colorectal, prostate, cervical, and lung)

    Per national guidelines \[National Comprehensive Cancer Network (NCCN), U.S. Preventive Services Task Force (USPSTF)\]; data derived from electronic health records

    Time frame: every 6 months from baseline to end of study (about 36 months from baseline)

07

Study locations

1 site
  • The University of Texas Health Science Center, Houston
    Houston, Texas 77030, United States
08

References and documents

Publications

  • Millett ME, Malthaner LQ, McCallister K, Craig DW, Eary R, Valerio-Shewmaker MA, Shay LA, Rajan SS, Ma HY, Ghosh S, Crabtree BF, Lee SJC, Balasubramanian BA. Community and Academic Synergy for Cancer Survivorship Care Delivery Enhancement (Project CASCADE): a study protocol for a pragmatic, stepped-wedge, cluster-randomized trial in Texas primary care community health centers. BMC Prim Care. 2025 Dec 27;27(1):18. doi: 10.1186/s12875-025-03108-1. PubMed 41454266 ↗

Individual participant data

Plan to share: No

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jul 24, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT06883838
Lead sponsor
The University of Texas Health Science Center, Houston
Collaborators
National Cancer Institute (NCI)
Responsible party
Bijal.A.Balasubramanian (Professor, The University of Texas Health Science Center, Houston) — Principal investigator
First posted
Mar 19, 2025
Start date
Sep 1, 2025
Primary completion
May 31, 2029 (estimated)
Completion
May 31, 2029 (estimated)
Last update
Jul 24, 2026

Study contacts

Bijal Balasubramanian, MBBS, PhD
principal investigator · The University of Texas Health Science Center, Houston
Simon Craddock Lee, PhD
principal investigator · University of Kansas Medical Center

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Interested in this study?

Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.

No contact was published for this record. The registry link below has the sponsor’s details.

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Start the discussion