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RecruitingNCT06882460Updated Apr 27, 2026

Diet and Exercise Solutions to Postprandial Hypotension

An interventional study of Low glycemic load and Electrical stimulation exercise in Spinal Cord Injuries, sponsored by Ohio State University. Recruiting at 1 site in United States. Open to participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2026-04-27.

Sponsored by Ohio State University · Not applicable, Interventional, and Basic science

From the registry’s dates

  • Started May 2025; still recruiting 1 year 4 months later.
Phase
Not applicable
Study type
Interventional
Enrollment
13
Allocation
Randomized
Ages
18 Years to 65 Years
Sex
All
01

Study summary

The purpose of this study is to determine if a low glycemic diet and lower-body electrical stimulation can reduce postprandial hypotension in individuals with chronic spinal cord injury.

02

Conditions studied

  • Spinal Cord Injuries

Keywords

  • postprandial hypotension
  • electrical stimulation
  • low-glycemic diet
03

In context

Spinal Cord Injuries

1,948 studies on the registry are indexed under Spinal Cord Injuries; 505 are open to participants now.

This study's planned enrollment of 13 is below the median of 24 across 1,566 interventional studies indexed under Spinal Cord Injuries.

Browse Spinal Cord Injuries studies →

Lead sponsor

Ohio State University is the lead sponsor of 640 studies on the registry; 144 are open to participants now.

Of its 60 completed or terminated interventional studies of FDA-regulated products, 45 (75%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 65 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • Spinal cord injury (SCI) between C4 and T12 who require use of wheelchair for daily mobility
  • AIS A or B
  • >1-year post-injury

Exclusion criteria

Exclusion Criteria:

  • Currently pregnant of breast-feeding
  • Type 1 or 2 diabetes
  • Previous gut augmentation bariatric surgery
  • Neurological impairment other than SCI
  • History of uncontrolled autonomic dysreflexia
  • History of bone fractures
  • Use of abdominal binder or anti-hypotensive drugs
  • Fitted with pacemaker or defibrillator
  • Currently receiving electrical stimulation training or in the previous year
05

Study design

Phase
Not applicable
Primary purpose
Basic science
Allocation
Randomized
Intervention model
Crossover assignment
Masking
None (open label)
Enrollment
13 participants (estimated)

Study arms

  • Placebo comparator
    High glycemic load

    Other: High glycemic load diet

  • Experimental
    Low glycemic load

    Other: Low glycemic load

  • Experimental
    Electrical Stimulation

    Other: Electrical stimulation exercise · Other: High glycemic load diet

Interventions

  • OtherLow glycemic load

    Low glycemic load diet

  • OtherElectrical stimulation exercise

    Lower-body electrical stimulation exercise for 1-h after eating

  • OtherHigh glycemic load diet

    High glycemic load diet

06

What researchers measure

Primary outcomes

  1. Magnitude of systolic blood pressure decrease (in-lab)

    Calculated as the maximum decrease in systolic blood pressure in the 2-h after eating breakfast and lunch under laboratory-controlled conditions

    Time frame: Visit 2-4, Day 1

Secondary outcomes

  1. Magnitude of systolic blood pressure decrease (at-home)

    Calculated as the maximum decrease in systolic blood pressure in the 2-h after eating breakfast, lunch, and dinner for 3-days during at-home testing

    Time frame: Visits 2-4, Days 1-3

  2. Postprandial glucose (in-lab)

    Blood samples will be obtained from an intravenous catheter at regular intervals after eating breakfast (3-h) and lunch (2-h) under laboratory controlled conditions.

    Time frame: Visits 2-4, Day 1

  3. Postprandial insulin (in-lab)

    Blood samples will be obtained from an intravenous catheter at regular intervals after eating breakfast (3-h) and lunch (2-h) under laboratory controlled conditions.

    Time frame: Visits 2-4, Day 1

  4. Postprandial glucose (at-home)

    A continuous glucose monitor will be used to measure glucose for 2-h after breakfast, lunch, and dinner for 3-days during at-home testing

    Time frame: Visits 2-4, Day 1-3

  5. Blood flow (in-lab)

    Blood flow at the radial, brachial, popliteal and superior mesenteric arteries will be obtained using Doppler imaging at regular intervals after eating breakfast (3-h) and lunch (2-h) under laboratory controlled conditions.

    Time frame: Visits 2-4, Day 1

07

Study locations

1 of 1 sites recruiting
  • Dodd Rehabilitation Hospital
    Columbus, Ohio 43210, United States
    Recruiting
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Apr 27, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT06882460
Lead sponsor
Ohio State University
Responsible party
Ceren Yarar-Fisher (Principal Investigator, The Craig H. Neilsen Foundation) — Principal investigator
First posted
Mar 18, 2025
Start date
May 15, 2025
Primary completion
Dec 1, 2026 (estimated)
Completion
Dec 1, 2026 (estimated)
Last update
Apr 27, 2026

Study contacts

Matthew Farrow, PhD
Contact
Matthew.Farrow@osumc.edu
614-293-2812
Ceren Yarar-Fisher, PhD
Contact
Ceren.Yarar-Fisher@osumc.edu

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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