CClinicalTrials.gg
WithdrawnNCT06869720Updated Feb 4, 2026

Eecentric Exercise on Cardiopulmonary Fitness and Quality of Life With Chronic Obstructive Pulmonary Disease

An interventional study of Eccentric bike and conventional group in COPD (Chronic Obstructive Pulmonary Disease), sponsored by Fu Jen Catholic University. Withdrawn at 1 site in Taiwan. Per ClinicalTrials.gov, last updated 2026-02-04.

Sponsored by Fu Jen Catholic University · Not applicable, Interventional, and Other

Why this study was withdrawn
Due to persistent challenges in participant recruitment, the study has been terminated and the protocol has been formally withdrawn.
Phase
Not applicable
Study type
Interventional
Enrollment
0
Allocation
Randomized
Sex
All
01

Study summary

This study aims to investigate the effects of elliptical exercise on the six-minute walk test and quality of life in patients with chronic obstructive pulmonary disease (COPD) to identify the most efficient exercise training method.

Read the detailed description

Background: Chronic respiratory diseases, including COPD, are leading causes of chronic illness and mortality worldwide. However, limitations in ventilation and muscle function restrict COPD patients from engaging in higher-power exercise therapies. Compared to concentric exercise, eccentric exercise can effectively improve health-related fitness and quality of life at lower cardiopulmonary and metabolic loads. Pulmonary rehabilitation programs have been shown to effectively improve symptoms of chronic respiratory diseases, increase exercise capacity, enhance quality of life, delay disease progression, prevent and treat acute exacerbations, and reduce mortality. Therefore, it is hoped that a "safe and effective" eccentric exercise strategy can be designed for COPD patients to comprehensively improve their cardiopulmonary/muscle fitness and quality of life, thereby improving the course of their disease.

Study Design: This is a one-year, single-center, prospective randomized controlled trial. Methods: This study plans to enroll 60 participants who will be randomly assigned to control and experimental groups. The intervention will take place in the pulmonary rehabilitation room on the sixth floor of Fu Jen Hospital. Each group will undergo a functional fitness test and complete a quality of life questionnaire before and after 24 sessions (over 12 weeks) of exercise training.

Effect: It is anticipated that after 24 sessions of elliptical exercise training, there will be an improvement in the functional fitness and in quality of life related to physical activity function.

Key words: Pulmonary rehabilitation; eccentric exercise; chronic obstructive pulmonary disease; cardiopulmonary fitness; functional fitness

02

Conditions studied

  • COPD (Chronic Obstructive Pulmonary Disease)

Keywords

  • Pulmonary rehabilitation
  • Eccentric exercise
  • Chronic obstructive pulmonary disease
  • Cardiopulmonary fitness
  • Functional fitness
03

In context

Pulmonary Disease, Chronic Obstructive

4,131 studies on the registry are indexed under Pulmonary Disease, Chronic Obstructive; 697 are open to participants now.

Browse Pulmonary Disease, Chronic Obstructive studies →

Lead sponsor

Fu Jen Catholic University is the lead sponsor of 43 studies on the registry; 22 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
Child (0–17), Adult (18–64), Older adult (65+)
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • Having undergone pulmonary rehabilitation for more than 3 months
  • Sign the written informed consent form
  • FEV1/FVC \< 0.70
  • Approval for exercise training granted by a specialist physician's assessment
  • Specialist physician's approval for exercise training

Exclusion criteria

Exclusion Criteria:

  • Existing of tracheostomy
  • Those who use oxygen therapy or ventilator at home
  • Severe heart failure (NYHA III-IV)
  • Neuromuscular disease
  • Acute exacerbation within the past three months
  • Those who are unable to cooperate with the cardiopulmonary exercise test
05

Study design

Phase
Not applicable
Primary purpose
Other
Allocation
Randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
0 participants (actual)

Study arms

  • Experimental
    Intervention Group: eccentric cycling exercise

    Received eccentric cycling exercise

    Device: Eccentric bike

  • Active comparator
    Control group

    Undergoing conventional treatment

    Other: conventional group

Interventions

  • DeviceEccentric bike

    Received eccentric cycling exercise

  • Otherconventional group

    Received conventional treatment

06

What researchers measure

Primary outcomes

  1. six minute walk test

    functional performance

    Time frame: 12 weeks

  2. time up and go

    functional performance

    Time frame: 12 weeks

  3. stairs ascending and descending walking time

    functional performance

    Time frame: 12 weeks

07

Study locations

1 site
  • Fu Jen Catholic University Hospital, Fu Jen Catholic University
    New Taipei City, 24352, Taiwan
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Feb 4, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT06869720
Lead sponsor
Fu Jen Catholic University
Responsible party
Ke-Yun, Chao (Assistant Professor, Fu Jen Catholic University) — Principal investigator
First posted
Mar 11, 2025
Start date
Mar 11, 2025
Primary completion
Jul 31, 2025
Completion
Jul 31, 2025
Last update
Feb 4, 2026

Study contacts

Ke-Yun Chao, PhD
principal investigator · Fu Jen Catholic University

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is withdrawn, as verified in Mar 2025. You cannot join it, but the record below documents what was studied.

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Start the discussion