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RecruitingNCT06866522Updated Mar 12, 2025

Light Reflection on Human Skin in Whole-Body Photobiomodulation Therapy

An interventional study of Whole-body Photobiomodulation Therapy in Photobiomodulation Therapy and Phototype, sponsored by Universidade Federal de Sao Carlos. Recruiting at 1 site in Brazil. Open to participants aged 18 Years to 30 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-03-12.

Sponsored by Universidade Federal de Sao Carlos · Not applicable, Interventional, and Health services research

From the registry’s dates

  • Primary completion was expected by Mar 2025, 1 year 6 months ago, but the record still lists the study as recruiting.
  • Registered 1 year 3 months after the study started (first participant enrolled Nov 2023, registered Feb 2025).
  • Started Nov 2023; still recruiting 2 years 10 months later.
Phase
Not applicable
Study type
Interventional
Enrollment
72
Allocation
Not applicable
Ages
18 Years to 30 Years
Sex
All
01

Study summary

Photobiomodulation therapy (PBMT) is based on exposing biological tissues to low-intensity light, with effects depending on the light-tissue interaction. When irradiated without skin contact, part of the incident light is reflected and lost. In this context, the amount of reflected light in PBMT applied without skin contact, as well as the influence of skin phototype, has not yet been established. Objective: To quantify the reflection of light from PBMT on the skin of men and women aged 18 to 30 years, considering skin phototypes. Methodology: Participants will be divided into three groups based on skin phototype (Group 1: phototypes I and II; Group 2: phototypes III and IV; Group 3: phototypes V and VI) and sex. They will be subjected to whole-body PBMT with red light (660 nm; 31.85±3.85 mW; 45.50±5.07 mW/cm²) and infrared light (850 nm; 25.29±2.99 mW; 36.13±4.27 mW/cm²) at 20 cm from the light-emitting source, with measurement of light reflection in the regions of the brachial biceps, abdomen, lumbar, anterior and posterior thigh, and calf using a power and energy analyzer (powermeter PM100D and sensor S130C, 0.7 cm²). Data will be analyzed for normality and groups were compared with a significance level of 5%

02

Conditions studied

  • Photobiomodulation Therapy
  • Phototype

Keywords

  • photobiomodulation
  • low-level laser therapy
  • skin optics
  • melanin
  • light reflection
03

In context

Lead sponsor

Universidade Federal de Sao Carlos is the lead sponsor of 85 studies on the registry; 8 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 30 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Inclusion criteria

  • male and female
  • age between 18 and 30 years
  • body mass index (BMI) between 18.5 and 29.9 kg/m2.

Exclusion criteria

Exclusion Criteria:

  • tattoo in the light reflection assessment areas
  • history of skin cancer
  • skin lesions such as open wounds in the mid-thigh, abdomen, biceps brachii, back and calf
  • patients with cognitive difficulty reporting thermal sensation
05

Study design

Phase
Not applicable
Primary purpose
Health services research
Allocation
Not applicable
Intervention model
Single group
Masking
None (open label)
Enrollment
72 participants (estimated)

Study arms

  • Experimental
    Photobiomodulation Reflection Group

    This group received measures of the light reflection using a whole-body photobiomodulation therapy with a Joovv device. In this group, participants were subclassified with the Fitzpatrick scale for their phototypes.

    Device: Whole-body Photobiomodulation Therapy

Interventions

  • DeviceWhole-body Photobiomodulation Therapy

    Whole-body Photobiomodulation Therapy applied for approximately 10 minutes, being 5 minutes with the red wavelength and 5 minutes with the infrared wavelength.

06

What researchers measure

Primary outcomes

  1. Light Reflection

    Light reflection will be measured in mW with a PowerMeter Device in the angles of 30º, 60º and 90º considering the participant in front of the whole-body photobiomodulation therapy device.

    Time frame: Acute measurement. The measurement will be performed just during the light therapy irradiation, on the day of the procedure.

07

Study locations

1 of 1 sites recruiting
  • Federal University of São Carlos (UFSCar)
    São Carlos, SP 13565-905, Brazil
    Recruiting
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Mar 12, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT06866522
Lead sponsor
Universidade Federal de Sao Carlos
Responsible party
Lara Maria Bataglia Espósito (Principal Investigator, Universidade Federal de Sao Carlos) — Principal investigator
First posted
Mar 10, 2025
Start date
Nov 27, 2023
Primary completion
Mar 20, 2025 (estimated)
Completion
Jul 20, 2025 (estimated)
Last update
Mar 12, 2025

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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