An interventional study of Centella asiatica extracellular vesicle formulation in Skin Quality, Skin Wrinkles and Melanin Hyperpigmentation, sponsored by Hungkuang University. Completed at 1 site in Taiwan. Open to participants aged 18 Years to 60 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-03-03.
Sponsored by Hungkuang University · Not applicable, Interventional, and Treatment
The study evaluates the effects of a skin care formulation containing Centella asiatica extracellular vesicles as the main active ingredient on facial appearance and skin quality in healthy participants.
Twenty healthy participants will be enrolled and will first undergo a 24-hour skin patch test on the forearm to assess potential irritation or allergic reactions to the test product. After screening, participants were asked to use the test product twice daily (morning and evening) after cleansing their face without using exfoliating products for 28 consecutive days. Each application involved 2 drops, evenly applied to the face using fingertips for absorption. Product usage was self-recorded, and the products were stored at room temperature.
The skin quality tests were conducted at the investigation site Hungkuang University onsite by the principal investigator. Each participant was to allocate 1 hour per test (including cleansing and waiting time). Skin quality tests were performed as a baseline test on day 0 (before using the test product), and subsequent tests at 7, 14, 21, and 28 days after test product use.
Measured parameters during assessment will include skin hydration, melanin content, skin elasticity, wrinkle percentage, redness area percentage, and pore percentage.
131 studies on the registry are indexed under Erythema; 17 are open to participants now.
This study's enrollment of 20 is below the median of 50 across 114 interventional studies indexed under Erythema.
Browse Erythema studies →Hungkuang University is the lead sponsor of 11 studies on the registry; 3 are open to participants now.
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Exclusion Criteria:
Water-based formulation containing purified Centella asiatica extracellular vesicle as main active ingredient.
Other: Centella asiatica extracellular vesicle formulation
Water-based formulation containing purified Centella asiatica extracellular vesicle as main active ingredient. Applied twice daily at two drops per use to the face after face cleansing for 28 consecutive days.
Change in skin hydration
To measure skin hydration from Day 0 Day 28 of the study using C+K Multi Probe Adaptor MPA580 system with Corneometer CM825 Data probe, which evaluates the dielectric constant related to epidermal moisture at a depth of 60-100 µm. Data will be expressed as percentage of change in skin hydration relative to Day 0.
Time frame: Assessment conducted every 7 days including Day 0 from Day 0 to Day 28 after treatment
Change in skin melanin content
To measure skin melanin content from Day 0 Day 28 of the study using C+K Multi Probe Adaptor MPA580 system with Mexameter MX18 probe, which measures melanin and hemoglobin content using RGB light absorption at wavelengths 568 nm, 660 nm, and 880 nm. Data will be expressed as percentage of change in skin melanin content relative to Day 0.
Time frame: Assessment conducted every 7 days including Day 0 from Day 0 to Day 28 after treatment
Change in skin elasticity
To measure skin elasticity from Day 0 Day 28 of the study using C+K Multi Probe Adaptor MPA580 system with Cutometer Dual MPA580 probe by measuring skin stretching properties using suction-based method. Data will be expressed as percentage of change in skin elasticity relative to Day 0.
Time frame: Assessment conducted every 7 days including Day 0 from Day 0 to Day 28 after treatment
Change in skin wrinkle percentage
To measure skin elasticity from Day 0 Day 28 of the study using VISIA Skin Analysis System by using standard white light to detect shadow variations to determine the distribution and number of wrinkles. Fewer wrinkles yield higher percentages. Data will be expressed as percentage of change in skin wrinkle percentage relative to Day 0.
Time frame: Assessment conducted every 7 days including Day 0 from Day 0 to Day 28 after treatment
Change in skin redness percentage
To measure skin elasticity from Day 0 Day 28 of the study using VISIA Skin Analysis System by using RBX polarized light to identify vascular or inflammatory issues. Smaller red zones result in higher percentages. Data will be expressed as percentage of change in skin redness percentage relative to Day 0.
Time frame: Assessment conducted every 7 days including Day 0 from Day 0 to Day 28 after treatment
Change in skin pore percentage
To measure skin elasticity from Day 0 Day 28 of the study using VISIA Skin Analysis System by using white light to analyze shadowed pore depressions and darker areas relative to surrounding skin. Fewer pores yield higher percentages. Data will be expressed as percentage of change in skin pore percentage relative to Day 0.
Time frame: Assessment conducted every 7 days including Day 0 from Day 0 to Day 28 after treatment
Ran from Sep 2024 to primary completion in Oct 2024, 1 month.
Of 23 non-industry interventional studies with no phase under Erythema, half reached primary completion within 10 months of starting (the median), counting those still running; a quarter within 2 and three quarters within 24. This study's 1 month is below that.
Counting every sponsor, half of 43 studies reached it within 3 months; a quarter within 1 and three quarters within 11.
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This study is completed, as verified in Feb 2025. You cannot join it, but the record below documents what was studied.
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Hungkuang University