An interventional study of Prescribed Medications and Deep brain stimulation adjustment in Movement Disorders, sponsored by University of Pennsylvania. Recruiting at 1 site in United States. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-07-14.
Sponsored by University of Pennsylvania · Not applicable, Interventional, and Basic science
The research study is being conducted to better understand parts of the human brain called the cortex, basal ganglia, thalamus, and cerebellum in patients with movement disorders (such as Parkinson's disease, essential tremor, dystonia, or ataxia). These brain structures are involved in movement disorders. This study attempts to better understand the brain electrical activity associated with these disorders, both in patients with and without deep brain stimulation (DBS). Recordings are made from the scalp with a noninvasive electrode and/or through the DBS stimulator if the participant has a stimulator model that is able to sense brain activity. These recordings are analyzed along with measures of movement disorder symptoms to identify brain signal signatures of symptoms.
371 studies on the registry are indexed under Movement Disorders; 102 are open to participants now.
This study's planned enrollment of 100 is above the median of 46 across 221 interventional studies indexed under Movement Disorders.
Browse Movement Disorders studies →University of Pennsylvania is the lead sponsor of 1,668 studies on the registry; 235 are open to participants now.
Of its 158 completed or terminated interventional studies of FDA-regulated products, 109 (69%) have results posted.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
- Patients with dementia
Multimodal neurophysiology (for example, electroencephalography and electromyography) will be measured during the following: Movement disorder medication administration -The patient's movement disorders medications, prescribed by their treating physicians outside of this study, may be administered during an experimental session.
Other: Prescribed Medications
Multimodal neurophysiology (for example, electroencephalography and electromyography) will be measured during the following: Movement disorder medication administration -The patient's movement disorders medications, prescribed by their treating physicians outside of this study, may be administered during an experimental session. Deep brain stimulator (DBS) adjustment - Participants who have had deep brain stimulation implantation as part of their standard-of-care clinical treatment may participate in this study. The patient's stimulator may be adjusted within normal clinical limits during an experimental session.
Other: Prescribed Medications · Other: Deep brain stimulation adjustment
participant's movement disorders medications, prescribed by their treating physician
Deep brain stimulator parameters may be adjusted within normal clinical limits
Neural signal biomarkers
Spatiotemporal patterns of brain neural activity (neural signal biomarkers / neurophysiologic signatures) associated with movement disorders symptoms.
Time frame: 5 years
Started Dec 2025 (actual). Primary completion is estimated for Apr 2030, 52 months after the start.
Of 83 non-industry interventional studies with no phase under Movement Disorders, half reached primary completion within 33 months of starting (the median), counting those still running; a quarter within 11 and three quarters within 80. This study's planned 52 months is above that.
Counting every sponsor, half of 85 studies reached it within 33 months; a quarter within 11 and three quarters within 80.
How these figures are worked out, and which studies are left out of them.
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