An interventional study of intermittent fasting and low volume high intensity interval training in Obesity, sponsored by Cairo University. Completed at 1 site in Egypt. Open to participants aged 35 Years to 50 Years. Per ClinicalTrials.gov, last updated 2025-02-19.
Sponsored by Cairo University · Not applicable, Interventional, and Treatment
we aimed to ascertain the effect of intermittent fasting (IF) vs. high-intensity interval training (HIIT) on the lipid profile and waist circumference (WC) of obese individuals.
Subjects and Methods: This study included 40 obese individuals of both genders aged 35-50 years with an abnormal lipid profile. The patients were allocated at random to either Group A or B, with both groups receiving medical treatment. Group A followed the IF regime, while Group B performed HIIT on the treadmill three times weekly, with an intervention duration of six weeks for both groups. Body mass index (BMI), WC, levels of total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL), high-density lipoprotein (HDL), alongside the Framingham risk score (FRS) were the evaluated variables.
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Inclusion criteria were as follows: (1) A BMI of 30 -40 kg/m2; (2) abnormal lipid profile, with a TC level > 200 mg/dL, an LDL > 100 mg/dL, a TC level > 150 mg/dL, and an HDL \< 40 mg/dL; (3) steady vital signs, including blood pressure, respiration rate, and temperature at a baseline level.
Exclusion Criteria:
Group A followed the intermittent fasting( IF) regime ,with an intervention duration of six weeks for both groups
Behavioral: intermittent fasting
High-intensity interval training performed on the treadmill three times weekly, with an intervention duration of six weeks for both groups
Behavioral: low volume high intensity interval training
Group A participants followed the IF diet for 6 weeks . intermittent fasting , specifically time-restricted feeding (TRF), involves consuming all of one's energy requirements inside an 8-h.The fasting interval was designated as 16 h, and the other 8-h was the eating period . During the 8-h eating window, the patient consumes a well-balanced meal consisting of 55%-65% carbs, 7%-20% protein, and 15%-30% fat .
. Group B engaged in low-volume HIIT exercise (aerobic activity) three times weekly for six weeks. The exercise routine consisted of a 5-min warm-up phase at 70% of MHR, followed by four intervals of 2-min maximum effort cycling sessions (4 × 2 HIIT) compared to a sub-maximal workload at 85%-90% of MHR. The participants engaged in four work bouts, with each bout lasting around 4 min and followed by a 4-min rest period. During the workouts, the participants maintained an HR of 60%-70% of their MHR. This resulted in 8 min of intense physical activity during each training session. Additionally, there was a 5-min cooling down phase at 70% of the MHR. The treatment's intensity was adapted based on the modified Bruce protocol.
lipid profile
A 5 mL fasting venous blood sample was collected following an eight-hour overnight fast, and LDL, HDL, TG, and TC levels were measured.
Time frame: lipid profile will be measured at baseline, and it will be measured again after six weeks
waist circumference
Utilizing tape measurements to measure WC.A WC \> 40 inches (102 cm) in males and \> 35 inches (88 cm) in women indicated an elevated risk for cardiometabolic disorders
Time frame: waist circumference will be measured at baseline, and it will be measured again after six weeks
The Framingham risk score (FRS)
It was employed to ascertain the cardiovascular disease risk over ten years.
Time frame: The Framingham risk score (FRS) will be measured at baseline, and it will be measured again after six weeks
This study is completed, as verified in Feb 2025. You cannot join it, but the record below documents what was studied.
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Cairo University