An interventional study of Exercise and Exercise in Stroke, Ischemic and Stroke Patients, sponsored by Poznan University of Physical Education. Completed at 1 site in Poland. Open to participants aged 21 Years to 75 Years. Per ClinicalTrials.gov, last updated 2025-02-13.
Sponsored by Poznan University of Physical Education · Not applicable, Interventional, and Basic science
The aim of this randomised experimental study is to test the effect of different intensities of aerobic exercise on neurotrophin concentration and functional and cognitive functions in post-stroke patients undertaking a single bout and 3-week exercise programme. The main questions to answer are:
The participants were randomly assigned to one of two groups: moderate-intensity continuous training on a bicycle ergometer and standard neurorehabilitation or low-intensity continuous training on a bicycle ergometer and standard neurorehabilitation. Training on a bicycle ergometer was performed four times a week for 45 min for 3 weeks. Each participant attended individual neurorehabilitation sessions 11 times per week (2 physical therapy sessions from Monday to Friday for 45 min each and 1 session on Saturday for 45 min) during the 3-week intervention.
Participants will have pre-tests and post-tests:
Researchers will compare two groups - moderate intensity continuous group and low intensity continuous group to see if there is a modulating effect of different intensities of exercise in participants' outcomes.
7,286 studies on the registry are indexed under Stroke; 2,007 are open to participants now.
This study's enrollment of 44 is below the median of 50 across 5,369 interventional studies indexed under Stroke.
Browse Stroke studies →Poznan University of Physical Education is the lead sponsor of 90 studies on the registry; 27 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Behavioral: Exercise
Behavioral: Exercise
Training on a bicycle ergometer was performed four times a week for 3 weeks for 45 min. The exercise intensity corresponded to 50%-60% of maximal oxygen uptake (VO2max).
Training on a bicycle ergometer was performed four times a week for 3 weeks for 45 min. The exercise intensity corresponded to 70 - 80% of maximal oxygen uptake (VO2max).
Brain-derived neurotrophic factor
Level of brain-derived neurotrophic factor in ng/ml
Time frame: Before and after 3-week intervention; pre and post single bout of exercise in the first day of intervention
Glial cell derived neurotrophic factor
Level of glial cell derived neurotrophic factor in ng/ml
Time frame: Before and after 3-week intervention; pre and post single bout of exercise in the first day of intervention
Insulin-like growth factor
Level of insulin-like growth factor in ng/ml
Time frame: Before and after 3-week intervention; pre and post single bout of exercise in the first day of intervention
irisin
Level of irisin in ng/ml
Time frame: Before and after 3-week intervention; pre and post single bout of exercise in the first day of intervention
Vascular-endothelial growth factor A
Level of Vascular-endothelial growth factor A in ng/ml
Time frame: Before and after 3-week intervention; pre and post single bout of exercise in the first day of intervention
The Graded Cycling Test with Talk Test
Cardiorespiratory fitness assessment with the Graded Cycling Test with Talk Test assess submaximal exercise in Watt. Higher Watt means better outcome.
Time frame: Before and after 3-week intervention
Vo2max
Physical performance assessment with Vo2max in mL/min/kg.
Time frame: Before and after 3-week intervention
Six Minute Walk Test
The 6 minute walking test assesses functional capacity during continuous walking on a 12-m ward hallway for 6 min. The test measures the distance a patient walks in 6 min.
Time frame: Before and after 3-week intervention
Rivermead Motor Assessment
Functional mobility among post-stroke patients was assessed with the Rivermead Motor Assessment, a performance-based measure in points. This later includes 38 items that cover three sections: gross function, leg and trunk and arm function. The total score ranges from 0 to 38 points. Higher scores indicate a higher degree of functional mobility.
Time frame: Before and after 3-week intervention
Barthel Index
The Barthel Index is a scale that measures an individual's functional outcomes. It consists of 10 items that assess activities of daily living, functional mobility, and gait. The score ranges from 0 to 100 points. The higher the score, the greater the individual's ability to self-care
Time frame: Before and after 3-week intervention
Addenbrooke's Cognitive Examination
Cognitive functions assessment with Addenbrooke's Cognitive Examination in points. Higher scores means better outcome.
Time frame: Before and after 3-week intervention
Beck Depression Inventory
Depressive symptoms assessment with Beck Depression Inventory in points. Higher scores means worse outcome.
Time frame: Before and after 3-week intervention
Plan to share: No
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This study is completed, as verified in Jan 2025. You cannot join it, but the record below documents what was studied.
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Poznan University of Physical Education