An interventional study of intact umbilical milking and cut umbilical milking in Premature and Placental Transfusion, sponsored by Alexandria University. Recruiting at 1 site in Egypt. Open to participants aged 1 Minute to 2 Minutes, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-01-16.
Sponsored by Alexandria University · Not applicable, Interventional, and Supportive care
The objective of this study is to evaluate the general course and prognosis associated with different methods of placental transfusion (Intact umbilical cord milking, cut- umbilical cord milking and delayed cord clamping) in premature neonates over the first days of life
Inclusion Criteria:
Exclusion criteria:
Patient with any of the following will be excluded:
Umbilical cord milking will be performed by holding the newborn at or ∼20 cm below the level of the placenta. The cord will be pinched between 2 fingers as close to the placenta as possible and milked toward the infant over a 2-second duration. The cord will then be released and allowed to refill with blood for a brief 1- to 2-second pause between each milking motion. This will be repeated for 2-4 times. After completion, the cord will be clamped, and the neonate will be handed to the resuscitation team.
Procedure: intact umbilical milking
Another technique, used more often in Asia, involves clamping and cutting a long segment of the umbilical cord immediately at birth and passing the baby and the long cord to the pediatric provider, called C-UCM untwists the cord and milks the entire contents into the baby. Milking the cord 2-3 times before clamping may produce a similar placental transfusion as C-UCM
Procedure: cut umbilical milking
Infants placed on the maternal abdomen or at the introitus below the level of placenta and waiting at least 30- to 60-second before clamping the cord.
Procedure: Delayed cord clamping
patients will not receive any of the methods of placental transfusions
Umbilical cord milking will be performed by holding the newborn at or ∼20 cm below the level of the placenta. The cord will be pinched between 2 fingers as close to the placenta as possible and milked toward the infant over a 2-second duration. The cord will then be released and allowed to refill with blood for a brief 1- to 2-second pause between each milking motion. This will be repeated for 2-4 times. After completion, the cord will be clamped, and the neonate will be handed to the resuscitation team.
Another technique, used more often in Asia, involves clamping and cutting a long segment of the umbilical cord immediately at birth and passing the baby and the long cord to the pediatric provider, called C-UCM untwists the cord and milks the entire contents into the baby. Milking the cord 2-3 times before clamping may produce a similar placental transfusion as C-UCM
Infants placed on the maternal abdomen or at the introitus below the level of placenta and waiting at least 30- to 60-second before clamping the cord.
Hemoglobin level
hemoglobin level will be measured in gram/dl
Time frame: on admission (In first day after birth),as well as, at end of first , second and third weeks of lives
Plan to share: Yes — Data will be available upon reasonable request
Supporting information: Study protocol
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Alexandria University