CClinicalTrials.gg
RecruitingNCT06808204QUALICATRYTHMUpdated Sep 28, 2026

Quality of Life Before and After Transcatheter Ablation in Children With Arrythmias

An observational study in Arrhythmia, sponsored by Hospices Civils de Lyon. Recruiting at 7 sites in France. Open to participants aged 5 Years to 17 Years. Per ClinicalTrials.gov, last updated 2026-09-28.

Sponsored by Hospices Civils de Lyon · Observational

Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
200
Ages
5 Years to 17 Years
Sex
All
01

Study summary

The goal of this clinical trial is to evaluate the improvement in the quality of life after the transcatheter ablation in children from 5 to 17 years old suffering for arrythmia who need a transcatheter ablation (according to PACES recommendations). The main question is how to evaluate an improvement in the quality of life in these children, according to different questionnaires?

Participants will answer some questionnaires to get a global evaluation of the quality of life:

  • Peds QL 4.0
  • Peds QL 4.0 by proxy, which will be completed by the parents
  • Ricci and Gagnon questionnaire
  • Child Depression Index
  • State and Trait Anxiety Inventory
02

Conditions studied

  • Arrhythmia

Browse trials for

Keywords

  • children
  • arrythmia
  • transcatheter ablation
  • quality of life
03

Who can participate

Ages eligible
5 Years to 17 Years
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Children from 5 to 17 years old suffering from arrythmias with transcathter ablation needed according to PACES recommendation, with medical care in one of the following center :

  • Lyon - HCL - Hôpital cardiologique Louis Pradel
  • Paris - AP HP - Necker enfant malades
  • Plessis Robinson - Hôpital Marie Lannelongue
  • Bordeaux - CHU Bordeaux - Haut Lévesque - Pessac
  • Toulouse - Clinique Pasteur
  • Marseille - AP HM - La Timone

Inclusion criteria

  • Patients aged 5 to 17
  • Patients with a rhythm disorder,
  • Patients with indication for catheter ablation according to PACES (Pediatric and Congenital Electrophysiology Society) recommendations,
  • Patients and/or their parents/legal guardians who have given their non-objection to the study.

Exclusion criteria

Exclusion Criteria:

  • Refusal of child or parents/legal guardians
  • Unability to understand and/or fill the quality of life questionnaire
04

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
200 participants (estimated)
Patient registry
No

Groups and cohorts

  • Children from 5 to 17 years old suffering for arrythmia who need a transcatheter ablation

    Other: Peds QL 4.0 (Pediatric Quality of Life) · Other: Ricci and Gagnon questionnaire · Other: State and Trait Inventory · Other: Child Depression Inventory · Other: PEDS QL 4.0 parents-child

Interventions

  • OtherPeds QL 4.0 (Pediatric Quality of Life)

    Quality of life questionnaire

  • OtherRicci and Gagnon questionnaire

    Physical activity level questionnaire

  • OtherState and Trait Inventory

    Anxiety questionnaire

  • OtherChild Depression Inventory

    Depression questionnaire

  • OtherPEDS QL 4.0 parents-child

    For parents before and after transcatheter ablation. Quality of life questionnaire.

05

What researchers measure

Primary outcomes

  1. Quality of life before and after transcatheter ablation

    Quality of life before and after transcatheter ablation according to Quality of Life Inventory paediatrics (PedsQL) version 4.0 questionnaire. The questionnaire consists of 23 questions covering 4 different areas: physical functioning (8 items), emotional functioning (5 items), social functioning (5 items) and academic functioning (5 items). A 5-point response scale is used across the child self-report (for ages 8 to 18) and parent proxy-report (0 = never a problem; 1 = almost never a problem; 2 = sometimes a problem; 3 = often a problem; 4 = almost always a problem). A 3-point scale is used for the young child self-report (ages 5 to 7) (0 = not at all a problem; 2 = sometimes a problem; 4 = a lot of a problem). Items are reverse-scored and linearly transformed to a 0-100 scale (0 = 100, 1 = 75, 2 = 50, 3= 25, 4 = 0), so that higher scores indicate a better assessment of health-related quality of life.

    Time frame: One day before transcatheter ablation

  2. Quality of life before and after transcatheter ablation

    Quality of life before and after transcatheter ablation according to Quality of Life Inventory paediatrics (PedsQL) version 4.0 questionnaire. The questionnaire consists of 23 questions covering 4 different areas: physical functioning (8 items), emotional functioning (5 items), social functioning (5 items) and academic functioning (5 items). A 5-point response scale is used across the child self-report (for ages 8 to 18) and parent proxy-report (0 = never a problem; 1 = almost never a problem; 2 = sometimes a problem; 3 = often a problem; 4 = almost always a problem). A 3-point scale is used for the young child self-report (ages 5 to 7) (0 = not at all a problem; 2 = sometimes a problem; 4 = a lot of a problem). Items are reverse-scored and linearly transformed to a 0-100 scale (0 = 100, 1 = 75, 2 = 50, 3= 25, 4 = 0), so that higher scores indicate a better assessment of health-related quality of life.

    Time frame: 3 months after transcatheter ablation

  3. Quality of life before and after transcatheter ablation

    Quality of life before and after transcatheter ablation according to Quality of Life Inventory paediatrics (PedsQL) version 4.0 questionnaire. The questionnaire consists of 23 questions covering 4 different areas: physical functioning (8 items), emotional functioning (5 items), social functioning (5 items) and academic functioning (5 items). A 5-point response scale is used across the child self-report (for ages 8 to 18) and parent proxy-report (0 = never a problem; 1 = almost never a problem; 2 = sometimes a problem; 3 = often a problem; 4 = almost always a problem). A 3-point scale is used for the young child self-report (ages 5 to 7) (0 = not at all a problem; 2 = sometimes a problem; 4 = a lot of a problem). Items are reverse-scored and linearly transformed to a 0-100 scale (0 = 100, 1 = 75, 2 = 50, 3= 25, 4 = 0), so that higher scores indicate a better assessment of health-related quality of life.

    Time frame: 6 months after transcatheter ablation

  4. Quality of life before and after transcatheter ablation

    Quality of life before and after transcatheter ablation according to Quality of Life Inventory paediatrics (PedsQL) version 4.0 questionnaire. The questionnaire consists of 23 questions covering 4 different areas: physical functioning (8 items), emotional functioning (5 items), social functioning (5 items) and academic functioning (5 items). A 5-point response scale is used across the child self-report (for ages 8 to 18) and parent proxy-report (0 = never a problem; 1 = almost never a problem; 2 = sometimes a problem; 3 = often a problem; 4 = almost always a problem). A 3-point scale is used for the young child self-report (ages 5 to 7) (0 = not at all a problem; 2 = sometimes a problem; 4 = a lot of a problem). Items are reverse-scored and linearly transformed to a 0-100 scale (0 = 100, 1 = 75, 2 = 50, 3= 25, 4 = 0), so that higher scores indicate a better assessment of health-related quality of life.

    Time frame: 12 months after transcatheter ablation

Secondary outcomes

  1. Comparing level of activity before and after transcatheter ablation

    Level of activity before and after transcatheter ablation according to to the Ricci and Gagnon questionnaire. The self-assessment questionnaire is used to determine the patient's activity profile: inactive, active or very active. It consists of 9 questions with 5 suggested answers (giving a score from 1 to 5 for each answer given). The higher the score, the more active the profile (Less than 18 points in total: Inactive, Between 18 and 35 points in total: Active, More than 35 points in total: Very active).

    Time frame: One day before transcatheter ablation

  2. Comparing level of activity before and after transcatheter ablation

    Level of activity before and after transcatheter ablation according to to the Ricci and Gagnon questionnaire The self-assessment questionnaire is used to determine the patient's activity profile: inactive, active or very active. It consists of 9 questions with 5 suggested answers (giving a score from 1 to 5 for each answer given). The higher the score, the more active the profile (Less than 18 points in total: Inactive, Between 18 and 35 points in total: Active, More than 35 points in total: Very active).

    Time frame: 3 months after transcatheter ablation

  3. Comparing level of activity before and after transcatheter ablation

    Level of activity before and after transcatheter ablation according to to the Ricci and Gagnon questionnaire The self-assessment questionnaire is used to determine the patient's activity profile: inactive, active or very active. It consists of 9 questions with 5 suggested answers (giving a score from 1 to 5 for each answer given). The higher the score, the more active the profile (Less than 18 points in total: Inactive, Between 18 and 35 points in total: Active, More than 35 points in total: Very active).

    Time frame: 6 months after transcatheter ablation

  4. Comparing level of activity before and after transcatheter ablation

    Level of activity before and after transcatheter ablation according to to the Ricci and Gagnon questionnaire. The self-assessment questionnaire is used to determine the patient's activity profile: inactive, active or very active. It consists of 9 questions with 5 suggested answers (giving a score from 1 to 5 for each answer given). The higher the score, the more active the profile (Less than 18 points in total: Inactive, Between 18 and 35 points in total: Active, More than 35 points in total: Very active).

    Time frame: 12 months after transcatheter ablation

  5. Comparing level of anxiety before and after transcatheter ablation

    Level of anxiety before and after transcatheter ablation according to the State-Trait Anxiety Inventory for Children (STAIC) questionnaire. The STAIC comprises 2 series of 20 items each: one concerns anxiety as a 'personality trait'; the other series concerns the subject's 'state of anxiety' at the time of completing the questionnaire, which may fluctuate over time. Each item is rated on a scale of 1 to 3. The overall score is obtained by a simple sum. The overall score varies between 20 and 60. The threshold score defining pathological anxiety is 34. The higher the score, the more anxious the patient.

    Time frame: One day before transcatheter ablation

  6. Comparing level of anxiety before and after transcatheter ablation

    Level of anxiety before and after transcatheter ablation according to the State-Trait Anxiety Inventory for Children (STAIC) questionnaire. The STAIC comprises 2 series of 20 items each: one concerns anxiety as a 'personality trait'; the other series concerns the subject's 'state of anxiety' at the time of completing the questionnaire, which may fluctuate over time. Each item is rated on a scale of 1 to 3. The overall score is obtained by a simple sum. The overall score varies between 20 and 60. The threshold score defining pathological anxiety is 34. The higher the score, the more anxious the patient.

    Time frame: 3 months after transcatheter ablation

  7. Comparing level of anxiety before and after transcatheter ablation

    Level of anxiety before and after transcatheter ablation according to the State-Trait Anxiety Inventory for Children (STAIC) questionnaire. The STAIC comprises 2 series of 20 items each: one concerns anxiety as a 'personality trait'; the other series concerns the subject's 'state of anxiety' at the time of completing the questionnaire, which may fluctuate over time. Each item is rated on a scale of 1 to 3. The overall score is obtained by a simple sum. The overall score varies between 20 and 60. The threshold score defining pathological anxiety is 34. The higher the score, the more anxious the patient.

    Time frame: 6 months after transcatheter ablation

  8. Comparing level of anxiety before and after transcatheter ablation

    Level of anxiety before and after transcatheter ablation according to the State-Trait Anxiety Inventory for Children (STAIC) questionnaire. The STAIC comprises 2 series of 20 items each: one concerns anxiety as a 'personality trait'; the other series concerns the subject's 'state of anxiety' at the time of completing the questionnaire, which may fluctuate over time. Each item is rated on a scale of 1 to 3. The overall score is obtained by a simple sum. The overall score varies between 20 and 60. The threshold score defining pathological anxiety is 34. The higher the score, the more anxious the patient.

    Time frame: 12 months after transcatheter ablation

  9. Comparing level of depression before and after transcatheter ablation

    Level of depression before and after transcatheter ablation according to the Child Depression Inventory (CDI) questionnaire. This questionnaire measures the intensity of depression in children and adolescents aged 7 to 17. Each item is scored from 0 (normal behaviour for age or absent) to 2 (severe). Adding the items together gives a total score of between 0 and 54. The higher the score, the more pathological the condition.

    Time frame: One day before transcatheter ablation

  10. Comparing level of depression before and after transcatheter ablation

    Level of depression before and after transcatheter ablation according to the Child Depression Inventory (CDI) questionnaire. This questionnaire measures the intensity of depression in children and adolescents aged 7 to 17. Each item is scored from 0 (normal behaviour for age or absent) to 2 (severe). Adding the items together gives a total score of between 0 and 54. The higher the score, the more pathological the condition.

    Time frame: 3 months after transcatheter ablation

  11. Comparing level of depression before and after transcatheter ablation

    Level of depression before and after transcatheter ablation according to the Child Depression Inventory (CDI) questionnaire. This questionnaire measures the intensity of depression in children and adolescents aged 7 to 17. Each item is scored from 0 (normal behaviour for age or absent) to 2 (severe). Adding the items together gives a total score of between 0 and 54. The higher the score, the more pathological the condition.

    Time frame: 6 months after transcatheter ablation

  12. Comparing level of depression before and after transcatheter ablation

    Level of depression before and after transcatheter ablation according to the Child Depression Inventory (CDI) questionnaire. This questionnaire measures the intensity of depression in children and adolescents aged 7 to 17. Each item is scored from 0 (normal behaviour for age or absent) to 2 (severe). Adding the items together gives a total score of between 0 and 54. The higher the score, the more pathological the condition.

    Time frame: 12 months after transcatheter ablation

  13. Quality of life of parents before and after transcatheter ablation

    Quality of life before and after transcatheter ablation according to PedsQL version 4.0 parents-kid questionnaire The questionnaire consists of 23 questions covering 4 different areas: physical functioning (8 items), emotional functioning (5 items), social functioning (5 items) and academic functioning (5 items). A 5-point response scale is used across the child self-report (for ages 8 to 18) and parent proxy-report (0 = never a problem; 1 = almost never a problem; 2 = sometimes a problem; 3 = often a problem; 4 = almost always a problem). A 3-point scale is used for the young child self-report (ages 5 to 7) (0 = not at all a problem; 2 = sometimes a problem; 4 = a lot of a problem). Items are reverse-scored and linearly transformed to a 0-100 scale (0 = 100, 1 = 75, 2 = 50, 3= 25, 4 = 0), so that higher scores indicate a better assessment of health-related quality of life.

    Time frame: One day before transcatheter ablation

  14. Quality of life of parents before and after transcatheter ablation

    Quality of life before and after transcatheter ablation according to PedsQL version 4.0 parents-kid questionnaire The questionnaire consists of 23 questions covering 4 different areas: physical functioning (8 items), emotional functioning (5 items), social functioning (5 items) and academic functioning (5 items). A 5-point response scale is used across the child self-report (for ages 8 to 18) and parent proxy-report (0 = never a problem; 1 = almost never a problem; 2 = sometimes a problem; 3 = often a problem; 4 = almost always a problem). A 3-point scale is used for the young child self-report (ages 5 to 7) (0 = not at all a problem; 2 = sometimes a problem; 4 = a lot of a problem). Items are reverse-scored and linearly transformed to a 0-100 scale (0 = 100, 1 = 75, 2 = 50, 3= 25, 4 = 0), so that higher scores indicate a better assessment of health-related quality of life.

    Time frame: 3 months after transcatheter ablation

  15. Quality of life of parents before and after transcatheter ablation

    Quality of life before and after transcatheter ablation according to PedsQL version 4.0 parents-kid questionnaire The questionnaire consists of 23 questions covering 4 different areas: physical functioning (8 items), emotional functioning (5 items), social functioning (5 items) and academic functioning (5 items). A 5-point response scale is used across the child self-report (for ages 8 to 18) and parent proxy-report (0 = never a problem; 1 = almost never a problem; 2 = sometimes a problem; 3 = often a problem; 4 = almost always a problem). A 3-point scale is used for the young child self-report (ages 5 to 7) (0 = not at all a problem; 2 = sometimes a problem; 4 = a lot of a problem). Items are reverse-scored and linearly transformed to a 0-100 scale (0 = 100, 1 = 75, 2 = 50, 3= 25, 4 = 0), so that higher scores indicate a better assessment of health-related quality of life.

    Time frame: 6 months after transcatheter ablation

  16. Quality of life of parents before and after transcatheter ablation

    Quality of life before and after transcatheter ablation according to PedsQL version 4.0 parents-kid questionnaire The questionnaire consists of 23 questions covering 4 different areas: physical functioning (8 items), emotional functioning (5 items), social functioning (5 items) and academic functioning (5 items). A 5-point response scale is used across the child self-report (for ages 8 to 18) and parent proxy-report (0 = never a problem; 1 = almost never a problem; 2 = sometimes a problem; 3 = often a problem; 4 = almost always a problem). A 3-point scale is used for the young child self-report (ages 5 to 7) (0 = not at all a problem; 2 = sometimes a problem; 4 = a lot of a problem). Items are reverse-scored and linearly transformed to a 0-100 scale (0 = 100, 1 = 75, 2 = 50, 3= 25, 4 = 0), so that higher scores indicate a better assessment of health-related quality of life.

    Time frame: 12 months after transcatheter ablation

06

Study locations

4 of 7 sites recruiting
  • Hôpital cardiologique Louis Pradel
    Bron, 69500, France
    Recruiting
  • Hôpital Marie Lannelongue
    Le Plessis-Robinson, 92350, France
    • Alice MALTRET, M.D · Contact · alice.maltret@gmail.com · 01 40 94 25 45
    • Alice MALTRET, M.D. · Principal investigator
    Recruiting
  • Hôpital de la Timone
    Marseille, 13385, France
    • Linda KOUTBI, M.D. · Contact · Rita.KOUTBI@ap-hm.fr · 04 91 38 65 75
    • Linda KOUTBI, M.D. · Principal investigator
    Recruiting
  • Hôpital Necker Enfants Malades
    Paris, 75015, France
    • Victor WALDMANN, M.D. · Contact · victor.waldmann@aphp.fr · 01 44 49 43 44
    • Victor WALDMANN, M.D. · Principal investigator
    Not yet recruiting
  • Hôpital Cardiologique du Haut Lévêque - Service de cardiologie-électrophysiologie et stimulation cardiaque
    Pessac, 33604, France
    Not yet recruiting
  • Hôpital Cardiologique du Haut Lévêque - Service des maladies cardio-vasculaires congénitales
    Pessac, 33604, France
    Not yet recruiting
  • Clinique Pasteur
    Toulouse, 31076, France
    Recruiting
07

Registry details

Key details

Study ID
NCT06808204
Lead sponsor
Hospices Civils de Lyon
Responsible party
Sponsor
First posted
Feb 5, 2025
Start date
Sep 23, 2025
Primary completion
Sep 23, 2029 (estimated)
Completion
Sep 23, 2029 (estimated)
Last update
Sep 28, 2026

Study contacts

Francis BESSIERE, PU-PH
Contact
francis.bessiere@chu-lyon.fr
04 72 35 75 65 ext. +33
Nawel BABOURI
Contact
nawel.babouri@chu-lyon.fr
04 26 73 93 83 ext. +33
Francis BESSIERE, PU-PH
principal investigator · Hôpital cardiologique Louis Pradel - Hospices Civils de Lyon Service Rythmologie

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
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